[1]李冬梅.高压氧治疗糖尿病足的疗效研究[J].国际内分泌代谢杂志,2014,(05):356-359.[doi:10.3760/cma.j.issn.1673-4157.2014.05.020]
　Li Dongmei..Therapeutic effects of hyperbaric oxygen on patients with diabetic foot[J].International Journal of Endocrinology and Metabolism,2014,(05):356-359.[doi:10.3760/cma.j.issn.1673-4157.2014.05.020]
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高压氧治疗糖尿病足的疗效研究()
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《国际内分泌代谢杂志》[ISSN:1673-4157/CN:12-1383/R]

卷:
期数:
2014年05期
页码:
356-359
栏目:
报道与交流
出版日期:
2014-10-31

文章信息/Info

Title:
Therapeutic effects of hyperbaric oxygen on patients with diabetic foot
作者:
李冬梅
300140 天津市第四中心医院高压氧科
Author(s):
Li Dongmei.
Department of Hyperbaric Oxygen Medicine,The Fourth Center Hospital of Tianjin, Tianjin 300140,China
关键词:
高压氧治疗;  糖尿病足;  疗效
Keywords:
Hyperbaric oxygen therapy;  Diabetic foot;  Therapeutic effect
DOI:
10.3760/cma.j.issn.1673-4157.2014.05.020
摘要:
目的 探讨高压氧治疗糖尿病足的临床疗效。方法 选取100例糖尿病足患者按照区组随机化分为高压氧组,对照组,各50例。对照组给予糖尿病饮食、降血糖、局部创面处理、抗感染等常规治疗,高压氧组在常规治疗基础之上同时予以高压氧治疗,高压氧治疗压力为0.20～0.25 MPa,患者吸纯氧60 min,每天1次,共6个疗程。观察治疗前、后空腹血糖、血液流变学、患侧下肢动脉血流峰值的变化情况。结果 治疗后,与对照组相比,高压氧组空腹血糖较低[(5.1±0.8)mmol/L vs.(7.2±0.7)mmol/L,P=0.011]; 血液流变学得到改善(t=2.381～3.854,P均<0.05); 患侧下肢动脉血流峰值较低(t=3.169～9.899,P均<0.05); 糖尿病足皮损明显改善[(2.11±1.34)cm2 vs.(3.65±1.65)cm2,P=0.021]。高压氧组总有效率和治愈率分别为98%和78%; 对照组总有效率和治愈率为76%和48%,差异有统计学意义(P<0.05)。结论 高压氧治疗糖尿病足疗效优于常规治疗,是糖尿病足治疗的有效途径。
Abstract:
Objective To study the therapeutic effects of hyperbaric oxygen treatment on patients with diabetic foot. Methods 100 patients with diabetic foot were divided into hyperbaric oxygen group(n=50)and control group(n=50)according to block randomization. Patients in control group recieved routine method such as diabetic diet intervention, blood glucose control, anti-intervention and local debridement. Patients in hyperbaric oxygen group were treated with hyperbaric oxygen therapy on the bases of routine treatment. The pressure in hyperbaric oxygen therapy was 0.2-0.25 MPa.All patients breathed pure oxygen for 60 minutes, once a day for a total of 6 course. Fasting blood glucose,hemorheology, lower extreme artery blood peak and skin lesions of diabetic foot and change of the above four indexes had been observed before and after treatment. Results After treatment, compared with control group, fasting blood glucose was lower[(5.1±0.8)mmol/L vs.(7.2±0.7)mmol/L, P=0.011], hemorheology was better(t =2.381-3.854,all P<0.05),lower extreme artery blood peak was lower(t=3.169-9.899, all P<0.05), and the improvement in skin lesion was better [(2.11±1.34)cm2 vs.(3.65±1.65)cm2, P=0.021]in hyperbaric oxygen group. The total effective rate and the cure rate for hyperbaric oxygen group were 98% and 78% respectively,and the rates for control group were 76% and 48%, respectively, the differences were significant(P<0.05). Conclusion Hyperbaric oxygen therapy has better efficacy than the routine treatment, which provides an effective way for treatment of diabetic foot.

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更新日期/Last Update: 2014-09-20