[1]艾华,谢岚.Irisin与代谢性疾病的关系[J].国际内分泌代谢杂志,2014,(05):316-320.[doi:10.3760/cma.j.issn.1673-4157.2014.05.008]
 Ai Hua,Xie Lan.Relationship between irisin and metabolic diseases[J].International Journal of Endocrinology and Metabolism,2014,(05):316-320.[doi:10.3760/cma.j.issn.1673-4157.2014.05.008]
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Irisin与代谢性疾病的关系()
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《国际内分泌代谢杂志》[ISSN:1673-4157/CN:12-1383/R]

卷:
期数:
2014年05期
页码:
316-320
栏目:
综述
出版日期:
2014-10-31

文章信息/Info

Title:
Relationship between irisin and metabolic diseases
作者:
艾华谢岚
100191 北京大学第三医院运动医学研究所营养研究室
Author(s):
Ai Hua Xie Lan
Lab of Nutrition, Institute of Sports Medicine, The Third Hospital of Peking University, Beijing 100191,China
关键词:
Irisin 代谢性疾病 脂肪分解代谢
Keywords:
Irisin Metabolic diseases Fat catabolism
DOI:
10.3760/cma.j.issn.1673-4157.2014.05.008
摘要:
Irisin是新发现的一个多肽激素,可对脂肪的分解代谢和体温调节产生作用。作为一个代谢性调控激素,irisin可能参与代谢性疾病的发生、发展。研究显示,肥胖引起irisin分泌增加,血浆irisin与体重、体重指数、腰围、体脂量呈正相关; 2型糖尿病患者血浆irisin水平明显降低,原因可能与irisin分泌代偿能力渐失、药物治疗、肾功能受损、胰岛素敏感性下降等因素有关; 非酒精性脂肪性肝病患者血浆irisin水平明显升高; 代谢综合征患者血浆irisin水平与甘油三酯和低密度脂蛋白-胆固醇呈正相关。
Abstract:
Irisin is a newly-discovered peptide hormone that can affect fat catabolism and thermoregulation. As a metabolic hormone, irisin may be involved in the occurrence and development of metabolic diseases. Obesity caused an increase of irisin secretion and plasma irisin has a positive correlation with weight, body mass index, waist circumference, and body fat mass. Plasma irisin content is reduced in patients with type 2 diabetes, probably due to gradual loss of compensatory ability of irisin secretion, drug therapy, renal impairment, decreased insulin sensitivity and other factors. The higher level of plasma irisin is found in patients with nonalcoholic fatty liver disease. Plasma irisin concentration is positively correlated with triglyceride and low density lipoprotein cholesterol levels in patients with metabolic syndrome.

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更新日期/Last Update: 2014-09-20