[1]包余婕,丁波,马建华.关于3β-羟基类固醇脱氢酶与代谢性疾病的相关研究进展[J].国际内分泌代谢杂志,2024,44(01):23-16.[doi:10.3760/cma.j.cn121383-20230220-02042]
 Bao Yujie,Ding Bo,Ma Jianhua.Research progress on 3β-hydroxysteroid dehydrogenase and metabolic diseases[J].International Journal of Endocrinology and Metabolism,2024,44(01):23-16.[doi:10.3760/cma.j.cn121383-20230220-02042]
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关于3β-羟基类固醇脱氢酶与代谢性疾病的相关研究进展()
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《国际内分泌代谢杂志》[ISSN:1673-4157/CN:12-1383/R]

卷:
44
期数:
2024年01期
页码:
23-16
栏目:
综述
出版日期:
2024-01-20

文章信息/Info

Title:
Research progress on 3β-hydroxysteroid dehydrogenase and metabolic diseases
作者:
包余婕丁波马建华
南京医科大学附属南京医院(南京市第一医院)内分泌代谢科,南京 210012
Author(s):
Bao Yujie Ding Bo Ma Jianhua
Department of Endocrinology and Metabolism, Nanjing First Hospital, Nanjing Medical University, Nanjing 210012, China
关键词:
3β-羟基类固醇脱氢酶 代谢性疾病 类固醇激素
Keywords:
3β-hydroxysteroid dehydrogenase Metabolic disease Steroid hormone
DOI:
10.3760/cma.j.cn121383-20230220-02042
摘要:
3β-羟基类固醇脱氢酶(3β-hydroxysteroid dehydrogenase,3β-HSD)参与多种甾体激素的合成,是影响代谢性疾病发生发展的重要生物标志物,以3β-HSD作为治疗靶点的药物已经成为了近年的研究热点。此文就3β-HSD在糖尿病、肥胖、高血压、多囊卵巢综合征以及非酒精性脂肪肝中潜在生理病理机制及临床应用前景的最新研究进展进行总结。
Abstract:
3β-hydroxysteroid dehydrogenase(3β-HSD)participates in the synthesis of a variety of steroid hormones and acts as an important biomarker that affects the occurrence and development of metabolic diseases. Drugs targeting 3β-HSD have become a research hotspot in recent years. In this paper, we summarize the latest research of the potential pathophysiological mechanism and clinical application prospect of 3β-HSD in diabetes, obesity, hypertension, polycystic ovary syndrome and nonalcoholic fatty liver disease.

参考文献/References:

[1] Zhu Q,Pan P,Chen X,et al.Human placental 3β-hydroxysteroid dehydrogenase/steroid Δ5,4-isomerase 1:Identity,regulation and environmental inhibitors[J].Toxicology,2019,425:152253.DOI:10.1016/j.tox.2019.152253.
[2] Simard J,Ricketts ML,Gingras S,et al.Molecular biology of the 3beta-hydroxysteroid dehydrogenase/delta5-delta4 isomerase gene family[J].Endocr Rev,2005,26(4):525-582.DOI:10.1210/er.2002-0050.
[3] 黄海花,朱岷.3β羟基类固醇脱氢酶缺乏症的研究进展[J].儿科药学杂志,2020,26(8):58-62.DOI:10.13407/j.cnki.jpp.1672-108X.2020.08.019.
[4] Michael P,Roversi G,Brown K,et al.Adrenal steroids and resistance to hormonal blockade of prostate and breast cancer[J].Endocrinology,2023,164(3):bqac218.DOI:10.1210/endocr/bqac218.
[5] Li D,Liu R,Wang M,et al.3β-Hydroxysteroid dehydrogenase expressed by gut microbes degrades testosterone and is linked to depression in males[J].Cell Host Microbe,2022,30(3):329-339.e5.DOI:10.1016/j.chom.2022.01.001.
[6] Thomas JL,Bucholtz KM,Kacsoh B.Selective inhibition of human 3β-hydroxysteroid dehydrogenase type 1 as a potential treatment for breast cancer[J].J Steroid Biochem Mol Biol,2011,125(1-2):57-65.DOI:10.1016/j.jsbmb.2010.08.003.
[7] Lee SH,Park SY,Choi CS.Insulin resistance:from mechanisms to therapeutic strategies[J].Diabetes Metab J,2022,46(1):15-37.DOI:10.4093/dmj.2021.0280.
[8] Oh JY,Barrett-Connor E,Wedick NM,et al.Endogenous sex hormones and the development of type 2 diabetes in older men and women:the Rancho Bernardo study[J].Diabetes Care,2002,25(1):55-60.DOI:10.2337/diacare.25.1.55.
[9] Nna VU,Bakar ABA,Ahmad A,et al.Down-regulation of steroidogenesis-related genes and its accompanying fertility decline in streptozotocin-induced diabetic male rats:ameliorative effect of metformin[J].Andrology,2019,7(1):110-123.DOI:10.1111/andr.12567.
[10] Wagner IV,Klöting N,Savchuk I,et al.Diabetes type 1 negatively influences leydig cell function in rats,Which is partially reversible by insulin treatment[J].Endocrinology,2021,162(4):bqab017.DOI:10.1210/endocr/bqab017.
[11] Hu Y,Wang Y,Cai T,et al.Short-time intensive insulin therapy upregulates 3 beta-and 17 beta-hydroxysteroid dehydrogenase levels in men with newly diagnosed T2DM[J].Front Endocrinol(Lausanne),2022,13:894743.DOI:10.3389/fendo.2022.894743.
[12] Kiani AK,Mor M,Bernini A,et al.Steroid-converting enzymes in human adipose tissues and fat deposition with a focus on AKR1C enzymes[J].Eur Rev Med Pharmacol Sci,2021,25(1 Suppl):23-32.DOI:10.26355/eurrev_202112_27330.
[13] Tchernof A,Mansour MF,Pelletier M,et al.Updated survey of the steroid-converting enzymes in human adipose tissues[J].J Steroid Biochem Mol Biol,2015,147:56-69.DOI:10.1016/j.jsbmb.2014.11.011.
[14] Blouin K,Nadeau M,Mailloux J,et al.Pathways of adipose tissue androgen metabolism in women:depot differences and modulation by adipogenesis[J].Am J Physiol Endocrinol Metab,2009,296(2):E244-E255.DOI:10.1152/ajpendo.00039.2008.
[15] Ta N,A L,E E,et al.Metabolomics analysis reveals amelioration effects of yellowhorn tea extract on hyperlipidemia,inflammation,and oxidative stress in high-fat diet-fed mice[J].Front Nutr,2023,10:1087256.DOI:10.3389/fnut.2023.1087256.
[16] Kannan S,Srinivasan D,Raghupathy PB,et al.Association between duration of obesity and severity of ovarian dysfunction in rat-cafeteria diet approach[J].J Nutr Biochem,2019,71:132-143.DOI:10.1016/j.jnutbio.2019.05.012.
[17] Suleiman JB,Nna VU,Othman ZA,et al.Orlistat attenuates obesity-induced decline in steroidogenesis and spermatogenesis by up-regulating steroidogenic genes[J].Andrology,2020,8(5):1471-1485.DOI:10.1111/andr.12824.
[18] Kupczyk D,Bilski R,Kozakiewicz M,et al.11β-HSD as a New Target in Pharmacotherapy of Metabolic Diseases[J].Int J Mol Sci,2022,23(16):8984.DOI:10.3390/ijms23168984.
[19] 钟宝,彭诚,Cha Y.高脂高盐饮食对大鼠醛固酮分泌和高血压的影响[J].营养学报,2021,43(4):384-388.DOI:10.3969/j.issn.0512-7955.2021.04.013.
[20] Tsilosani A,Gao C,Zhang W.Aldosterone-Regulated sodium transport and blood pressure[J].Front Physiol,2022,13:770375.DOI:10.3389/fphys.2022.770375.
[21] Murrell JR,Randall JD,Rosoff J,et al.Endogenous ouabain:upregulation of steroidogenic genes in hypertensive hypothalamus but not adrenal[J].Circulation,2005,112(9):1301-1308.DOI:10.1161/CIRCULATIONAHA.105.554071.
[22] Simonini M,Casanova P,Citterio L,et al.Endogenous ouabain and related genes in the translation from hypertension to renal diseases[J].Int J Mol Sci,2018,19(7):1948.DOI:10.3390/ijms19071948.
[23] Salvi E,Wang Z,Rizzi F,et al.Genome-wide and gene-based meta-analyses identify novel loci influencing blood pressure response to hydrochlorothiazide[J].Hypertension,2017,69(1):51-59.DOI:10.1161/HYPERTENSIONAHA.116.08267.
[24] Froment P,Plotton I,Giulivi C,et al.At the crossroads of fertility and metabolism:the importance of AMPK-dependent signaling in female infertility associated with hyperandrogenism[J].Hum Reprod,2022,37(6):1207-1228.DOI:10.1093/humrep/deac067.
[25] Piotrowska A,Pilch W,Czerwińska-Ledwig O,et al.The possibilities of using chromium salts as an agent supporting treatment of polycystic ovary syndrome[J].Biol Trace Elem Res,2019,192(2):91-97.DOI:10.1007/s12011-019-1654-5.
[26] Yu J,Liu Y,Zhang D,et al.Baicalin inhibits recruitment of GATA1 to the HSD3B2 promoter and reverses hyperandrogenism of PCOS[J].J Endocrinol,2019,JOE-18-0678.R2.DOI:10.1530/JOE-18-0678.
[27] Friedman SL,Neuschwander-Tetri BA,Rinella M,et al.Mechanisms of NAFLD development and therapeutic strategies[J].Nat Med,2018,24(7):908-922.DOI:10.1038/s41591-018-0104-9.
[28] Ge MX,Niu WX,Ren JF,et al.A novel ASBT inhibitor,IMB17-15,repressed nonalcoholic fatty liver disease development in high-fat diet-fed syrian golden hamsters[J].Acta Pharmacol Sin,2019,40(7):895-907.DOI:10.1038/s41401-018-0195-3.
[29] Zhao J,Setchell KDR,Gong Y,et al.Genetic spectrum and clinical characteristics of 3β-hydroxy-Δ5-C27-steroid oxidoreductase(HSD3B7)deficiency in China[J].Orphanet J Rare Dis,2021,16(1):417.DOI:10.1186/s13023-021-02041-7.

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备注/Memo

备注/Memo:
通信作者:马建华,Email: majianhua196503@126.com
更新日期/Last Update: 2024-03-20