[1]吴丹,李竹.H型高血压患者血尿酸与左心室重构的关系[J].国际内分泌代谢杂志,2023,43(02):91-95.[doi:10.3760/cma.j.cn121383-20211129-11083]
　Wu Dan,Li Zhu..Relationship between serum uric acid and left ventricular remodeling in patients with H-type hypertension[J].International Journal of Endocrinology and Metabolism,2023,43(02):91-95.[doi:10.3760/cma.j.cn121383-20211129-11083]
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H型高血压患者血尿酸与左心室重构的关系()
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《国际内分泌代谢杂志》[ISSN:1673-4157/CN:12-1383/R]

卷:
43
期数:
2023年02期
页码:
91-95
栏目:
论著
出版日期:
2023-03-20

文章信息/Info

Title:
Relationship between serum uric acid and left ventricular remodeling in patients with H-type hypertension
作者:
吴丹; 李竹
天津医科大学朱宪彝纪念医院、天津市内分泌研究所、国家卫生健康委员会激素与发育重点实验室、天津市代谢性疾病重点实验室,天津 300134
Author(s):
Wu Dan;  Li Zhu.
NHC Key Laboratory of Hormone and Development, Tianjin Key Laboratory of Metabolic Diseases, Chu Hsien-I Memorial Hospital and Tianjin Institute of Endocrinology, Tianjin Medical University, Tianjin 300134, China
关键词:
高尿酸血症;  同型半胱氨酸;  左心室重构;  H型高血压病
Keywords:
Hyperuricemia;  Homocysteine;  Left ventricular remodeling;  H-type hypertension
DOI:
10.3760/cma.j.cn121383-20211129-11083
摘要:
目的 伴高同型半胱氨酸血症的高血压即H型高血压。本研究探讨H型高血压患者血尿酸与左心室重构的关系。方法 收集2019年6月至2021年6月于天津医科大学朱宪彝纪念医院心内科就诊且符合标准的330例H型高血压患者,根据血尿酸水平分为高尿酸血症(HUA)组(114例)及Non-HUA组(216例)。再以血尿酸水平按四分位数分为4组,应用SPSS 23.0统计软件进行t检验、秩和检验、χ2检验、多元logistic回归分析。结果 HUA组与Non-HUA在年龄、性别、肌酐方面差异有统计学意义(P均<0.05),HUA组左室舒张末期内径(LVEDD)、左室收缩末期内径(LVESD)、左室后壁厚度(LVPW)、室间隔厚度(IVS)、左室质量(LVM)、左室质量指数(LVMI)较Non-HUA组明显增加,差异有统计学意义(P均<0.05),血尿酸最高四分位数组LVMI高于其余3组,差异有统计学意义(P均<0.05)。多元logistic回归结果显示,血尿酸(OR=1.006,95% CI:1.002～1.010)、性别(OR=4.420,95% CI:1.523～12.826)与左心室重构高风险相关(P均<0.05)。在2型糖尿病人群中,多元logistic回归结果同样提示,血尿酸(OR=1.006,95% CI:1.001～1.011)、性别(OR=4.043,95% CI:1.293～12.643)与左心室重构高风险相关(P均<0.05)。结论 H型高血压患者血尿酸可能是左心室重构的影响因素。
Abstract:
Objective To explore the relationship between serum uric and left ventricular remodeling in patients with H-type hypertension.Methods 330 H-type hypertension patients in the Department of Cardiology from June 2019 to June 2021 were collected. According to serum uric acid(SUA)value, they were divided into hyperuricemia(HUA)group(114 cases)and non-HUA group(216 cases). The SUA levels were divided into four quartile groups. SPSS 23.0 software was used for T test, rank sum test, chi-square test, and binary logistic regression analysis.Results There were statistically significant differences in age, sex and creatinine between HUA group and non-HUA group(all P<0.05).Left ventricular end diastolic dimension(LVEDD), left ventricular end systolic dimension(LVESD), left ventricular posterior wall thickness(LVPW), interventricular septum thickness(IVS), left ventricular mass(LVM)and left ventricular mass index(LVMI)in HUA group were significantly increased compared with non-HUA group, and the differences were statistically significant(all P<0.05). The LVMI of highest quartile of SUA was higher than the other three groups(all P<0.05). Multivariate logistic regression results showed that SUA(OR=1.006, 95% CI: 1.002-1.010)and gender(OR=4.420, 95% CI: 1.523-12.826)were correlated with high risk of left ventricular remodeling(all P<0.05). In type 2 diabetes, the results of multiple logistic regression also showed that SUA(OR=1.006, 95% CI: 1.001-1.011)and gender(OR=4.043, 95% CI:1.293-12.643)were correlated with high risk of left ventricular remodeling(all P<0.05).Conclusions SUA in patients with H-type hypertension may be a factor affecting left ventricular remodeling.

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备注/Memo

备注/Memo:
基金项目:天津市教委科研计划项目(2018KJ071)
通信作者:李竹,Email:bamboo19820123@163.com
更新日期/Last Update: 2023-04-15