[1]杨亚梅,朱惠娟.催产素对摄食及糖脂代谢调节作用的研究进展[J].国际内分泌代谢杂志,2023,43(01):54-57.[doi:10.3760/cma.j.cn121383-20210426-04069]
 Yang Yamei,Zhu Huijuan..Research progress of oxytocin on eating behavior and glycolipid metabolism regulation[J].International Journal of Endocrinology and Metabolism,2023,43(01):54-57.[doi:10.3760/cma.j.cn121383-20210426-04069]
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催产素对摄食及糖脂代谢调节作用的研究进展()
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《国际内分泌代谢杂志》[ISSN:1673-4157/CN:12-1383/R]

卷:
43
期数:
2023年01期
页码:
54-57
栏目:
综述
出版日期:
2023-01-20

文章信息/Info

Title:
Research progress of oxytocin on eating behavior and glycolipid metabolism regulation
作者:
杨亚梅朱惠娟
中国医学科学院,北京协和医学院,北京协和医院内分泌科,国家卫生健康委员会内分泌重点实验室,疑难重症及罕见病国家重点实验室,北京 100730
Author(s):
Yang Yamei Zhu Huijuan.
Key Laboratory of Endocrinology of National Health Commission, Department of Endocrinology, State Key Laboratory of Complex Severe and Rare Diseases,Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing 100730, China
关键词:
催产素 糖脂代谢 摄食 脂肪 葡萄糖
Keywords:
Oxytocin Glycolipid metabolism Eating behavior Lipid Glycose
DOI:
10.3760/cma.j.cn121383-20210426-04069
摘要:
催产素是一种由下丘脑室旁核和视上核神经元合成,经神经垂体释放入血的肽类激素。研究发现催产素除促进宫缩和泌乳之外,还能抑制摄食、促进脂肪氧化分解、刺激胰岛素和胰高血糖素分泌、增加胰岛素敏感性,在机体糖脂代谢中发挥重要的调节作用。但机体存在糖脂代谢异常时,外源性催产素的作用及血清催产素的变化存在差异。全面认识催产素对糖脂代谢的影响及其内在机制,有助于进一步探索催产素通路作为代谢相关疾病治疗靶点的前景。
Abstract:
Oxytocin, a peptide hormone, is synthesized by neurons in the hypothalamus paraventricular and supraoptic nucleus, secreting into blood via the neurohypophysis. Besides parturition and lactation, oxytocin also plays an important role in organic glucolipid metabolism, including inhibiting eating behavior, promoting lipolysis, stimulating insulin and glucagon secretion, and enhancing insulin sensitivity. However, the effects of exogenous oxytocin on glucolipid metabolism differ, as well as endogenous oxytocin levels when bodies in abnormal states. The insight into these differences and their internal mechanisms are needed to explore the prospect of oxytocin pathway as a therapeutic target for metabolic diseases.

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备注/Memo

备注/Memo:
通信作者:朱惠娟,Email: shengxin2004@163.com
基金项目:中国医学科学院医学与健康科技创新工程(CAMS-2016-I2M-1-002)
更新日期/Last Update: 2023-01-30