[1]杨雪,陈煜,陈国芳,等.缓解1型糖尿病新策略:以调节性T细胞为干预靶点[J].国际内分泌代谢杂志,2023,43(01):38-41.[doi:10.3760/cma.j.cn121383-20211227-12064]
 Yang Xue,Chen Yu,Chen Guofang,et al.A new strategy for reversing type 1 diabetes: targeting regulatory T cells[J].International Journal of Endocrinology and Metabolism,2023,43(01):38-41.[doi:10.3760/cma.j.cn121383-20211227-12064]
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缓解1型糖尿病新策略:以调节性T细胞为干预靶点()
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《国际内分泌代谢杂志》[ISSN:1673-4157/CN:12-1383/R]

卷:
43
期数:
2023年01期
页码:
38-41
栏目:
综述
出版日期:
2023-01-20

文章信息/Info

Title:
A new strategy for reversing type 1 diabetes: targeting regulatory T cells
作者:
杨雪陈煜陈国芳刘超
南京中医药大学附属中西医结合医院内分泌科,南京 210028
Author(s):
Yang Xue Chen Yu Chen Guofang Liu Chao.
Department of Endocrinology, Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Traditional Chinese Medicine,Nanjing 210028, China
关键词:
1型糖尿病 调节性T细胞 防治 逆转 缓解
Keywords:
Type 1 diabetes mellitus Regulatory T cells Prevention and control Reversal Remission
DOI:
10.3760/cma.j.cn121383-20211227-12064
摘要:
1型糖尿病主要是由T细胞介导的针对胰岛β细胞的自身免疫性疾病,主要依赖胰岛素治疗,移植疗法可有效恢复胰岛功能,但存在术后排异等问题。近来的研究发现,调节性T细胞在1型糖尿病的发生发展以及移植治疗后的免疫稳态中发挥着关键作用。以调节性T细胞为干预靶点的疗法可作为一种重要手段在1型糖尿病中减轻(消除)自身免疫,以延缓疾病进展或逆转疾病进程; 应用于1型糖尿病移植治疗后,则可缓解乃至消除术后的排异反应。该策略为1型糖尿病的治疗及缓解开辟了新的思路。
Abstract:
Type 1 diabetes is an autoimmune disease mainly mediated by T cells and targeted at islet beta cells. It mainly relies on insulin therapy. Transplantation therapy can effectively restore the function of the islet, but there are problems such as postoperative rejection. Recently, regulatory T cells have been found to play an important role in the development of type 1 diabetes and in immune homeostasis after transplantation therapy. Therapies targeting regulatory T cells may be a means to reduce/eliminate autoimmunity, delay disease progression, or reverse disease progression in type 1 diabetes; After transplantation for type 1 diabetes, it can alleviate/eliminate the rejection reaction after surgery. This strategy provides a new idea for the treatment and reversal of T1DM.

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备注/Memo

备注/Memo:
通信作者:陈国芳,Email:chenguofang9801@126.com; 刘超,Email:liuchao@nfmcn.com
基金项目:江苏省第十六批“六大人才高峰”项目(WSN-035)
更新日期/Last Update: 2023-01-30