[1]何茹,徐加杰.甲状腺癌免疫微环境的研究进展[J].国际内分泌代谢杂志,2023,43(01):30-33.[doi:10.3760/cma.j.cn121383-20211116-11047]
 He Ru,Xu Jiajie..Advances in the study of immune microenvironment of thyroid cancer[J].International Journal of Endocrinology and Metabolism,2023,43(01):30-33.[doi:10.3760/cma.j.cn121383-20211116-11047]
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甲状腺癌免疫微环境的研究进展()
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《国际内分泌代谢杂志》[ISSN:1673-4157/CN:12-1383/R]

卷:
43
期数:
2023年01期
页码:
30-33
栏目:
综述
出版日期:
2023-01-20

文章信息/Info

Title:
Advances in the study of immune microenvironment of thyroid cancer
作者:
何茹12徐加杰13
1浙江省人民医院头颈外科、耳鼻咽喉-头颈外科中心,杭州医学院附属人民医院,杭州 310014; 2杭州医学院基础医学与法医学院,杭州 310012; 3浙江省内分泌腺体疾病诊治研究重点实验室,杭州 310014
Author(s):
He Ru12 Xu Jiajie13.
1Department of Head and Neck Surgery, Center of Otolaryngology-Head and Neck Surgery, Zhejiang Provincial People's Hospital, Affiliated People's Hospital, Hangzhou Medical College, Hangzhou 310014, China; 2School of Basic Medical Sciences and Forensic Medicine, Hangzhou Medical College, Hangzhou 310012, China; 3Key Laboratory of Endocrine Gland Diseases of Zhejiang Province, Hangzhou 310014, China
关键词:
甲状腺癌 免疫微环境 免疫治疗
Keywords:
Thyroid cancer Immune microenvironment Immunotherapy
DOI:
10.3760/cma.j.cn121383-20211116-11047
摘要:
通信作者:徐加杰,Email:xujiajie@hmc.edu.cn
Abstract:
Thyroid cancer(TC)is a common endocrine malignant tumor, which mainly depends on surgical treatment. The common papillary thyroid carcinoma(PTC)is not sensitive to chemical drugs, radiation therapy and other traditional treatments. With the widespread of immunotherapy in the field of tumor therapy, researchers have gradually begun to pay attention to the immune microenvironment of thyroid cancer in order to explore TC immunotherapy strategies. In this paper, the immune microenvironment of Thyroid cancer is used as a starting point. The immune microenvironment components of differentiated thyroid carcinoma(DTC), medullary thyroid carcinoma(MTC)and anaplastic thyroid carcinoma(ATC), and the characteristics of tumor-immune microenvironment interaction are reviewed. The research progress of thyroid cancer immune microenvironment in recent years is summarized.

参考文献/References:

[1] Miranda-Filho A,Lortet-Tieulent J,Bray F,et al.Thyroid cancer incidence trends by histology in 25 countries:a population-based study[J].Lancet Diabetes Endocrinol,2021,9(4):225-234.DOI:10.1016/S2213-8587(21)00027-9.
[2] Abdullah MI,Junit SM,Ng KL,et al.Papillary thyroid cancer:genetic alterations and molecular biomarker investigations[J].Int J Med Sci,2019,16(3):450-460.DOI:10.7150/ijms.29935.
[3] Mao M,Huang RZ,Zheng J,et al.OGDHL closely associates with tumor microenvironment and can serve as a prognostic biomarker for papillary thyroid cancer[J].Cancer Med,2021,10(2):728-736.DOI:10.1002/cam4.3640.
[4] Means C,Clayburgh DR,Maloney L,et al.Tumor immune microenvironment characteristics of papillary thyroid carcinoma are associated with histopathological aggressiveness and BRAF mutation status[J].Head Neck,2019,41(8):2636-2646.DOI:10.1002/hed.25740.
[5] Bai Y,Guo T,Huang X,et al.In papillary thyroid carcinoma,expression by immunohistochemistry of RAFV600E,PD-L1,and PD-1 is closely related[J].Virchows Arch,2018,472(5):779-787.DOI:10.1007/s00428-018-2357-6.
[6] Gogali F,Paterakis G,Rassidakis GZ,et al.CD3(-)CD16(-)CD56(bright)immunoregulatory NK cells are increased in the tumor microenvironment and inversely correlate with advanced stages in patients with papillary thyroid cancer[J].Thyroid,2013,23(12):1561-1568.DOI:10.1089/thy.2012.0560.
[7] Gulubova MV,Ivanova KV.The Expression of tumor-associated macrophages and multinucleated giant cells in papillary thyroid carcinoma[J].Open Access Maced J Med Sci,2019,7(23):3944-3949.DOI:10.3889/oamjms.2019.715.
[8] Pan J,Ye F,Yu C,et al.Papillary thyroid carcinoma landscape and Its immunological link with hashimoto thyroiditis at single-cell resolution[J].Front Cell Dev Biol,2021,9:758339.DOI:10.3389/fcell.2021.758339.
[9] Binnewies M,Roberts EW,Kersten K,et al.Understanding the tumor immune microenvironment(TIME)for effective therapy[J].Nat Med,2018,24(5):541-550.DOI:10.1038/s41591-018-0014-x.
[10] Na KJ,Choi H.Immune landscape of papillary thyroid cancer and immunotherapeutic implications[J].Endocr Relat Cancer,2018,25(5):523-531.DOI:10.1530/ERC-17-0532.
[11] Cunha LL,Nonogaki S,Soares FA,et al.Immune Escape Mechanism is Impaired in the Microenvironment of Thyroid Lymph Node Metastasis[J].Endocr Pathol,2017,28(4):369-372.DOI:10.1007/s12022-017-9495-2.
[12] Xie Z,Li X,He Y,et al.Immune Cell Confrontation in the Papillary Thyroid Carcinoma Microenvironment[J].Front Endocrinol(Lausanne),2020,11:570604.DOI:10.3389/fendo.2020.570604.
[13] Fagin JA,Wells SA Jr.Biologic and clinical perspectives on thyroid cancer[J].N Engl J Med,2016,375(11):1054-1067.DOI:10.1056/NEJMra1501993.
[14] Han J,Hong Y,Lee Y S.PD-L1 Expression and Combined Status of PD-L1/PD-1-Positive Tumor Infiltrating Mononuclear Cell Density Predict Prognosis in Glioblastoma Patients[J].J Pathol Transl Med,2017,51(1):40-48.DOI:10.4132/jptm.2016.08.31.
[15] Shi X,Yu PC,Lei BW,et al.Association between programmed Death-Ligand 1 expression and clinicopathological characteristics,structural recurrence,and biochemical recurrence/persistent disease in medullary thyroid carcinoma[J].Thyroid,2019,29(9):1269-1278.DOI:10.1089/thy.2019.0079.
[16] Zalatnai A.Molecular aspects of stromal-parenchymal interactions in malignant neoplasms[J].Curr Mol Med,2006,6(6):685-693.DOI:10.2174/156652406778195053.
[17] Koperek O,Bergner O,Pichlhöfer B,et al.Expression of hypoxia-associated proteins in sporadic medullary thyroid cancer is associated with desmoplastic stroma reaction and lymph node metastasis and may indicate somatic mutations in the VHL gene[J].J Pathol,2011,225(1):63-72.DOI:10.1002/path.2926.
[18] Maio M,Coral S,Sigalotti L,et al.Analysis of cancer/testis antigens in sporadic medullary thyroid carcinoma:expression and humoral response to NY-ESO-1[J]. J Clin Endocrinol Metab,2003,88(2):748-754.DOI:10.1210/jc.2002-020830.
[19] Yang J,Barletta JA.Anaplastic thyroid carcinoma[J].Semin Diagn Pathol,2020,37(5):248-256.DOI:10.1053/j.semdp.2020.06.005.
[20] Gunda V,Gigliotti B,Ashry T,et al.Anti-PD-1/PD-L1 therapy augments lenvatinib's efficacy by favorably altering the immune microenvironment of murine anaplastic thyroid cancer[J].Int J Cancer,2019,144(9):2266-2278.DOI:10.1002/ijc.32041.
[21] Cristinziano L,Modestino L,Loffredo S,et al.Anaplastic Thyroid Cancer Cells Induce the Release of Mitochondrial Extracellular DNA Traps by Viable Neutrophils[J].J Immunol,2020,204(5):1362-1372.DOI:10.4049/jimmunol.1900543.
[22] Duquette M,Sadow PM,Lawler J,et al.Thrombospondin-1 silencing Down-Regulates integrin expression levels in human anaplastic thyroid cancer cells with RAFV600E:new insights in the host tissue adaptation and homeostasis of tumor microenvironment[J].Front Endocrinol(Lausanne),2020,11:596223.DOI: 10.3389/fendo.2020.596223.
[23] Gunda V,Gigliotti B,Ndishabandi D,et al.Combinations of BRAF inhibitor and anti-PD-1/PD-L1 antibody improve survival and tumour immunity in an immunocompetent model of orthotopic murine anaplastic thyroid cancer[J].Br J Cancer,2018,119(10):1223-1232.DOI:10.1038/s41416-018-0296-2.
[24] Passaro C,Borriello F,Vastolo V,et al.The oncolytic virus dl922-947 reduces IL-8/CXCL8 and MCP-1/CCL2 expression and impairs angiogenesis and macrophage infiltration in anaplastic thyroid carcinoma[J].Oncotarget,2016,7(2):1500-1515.DOI:10.18632/oncotarget.6430.
[25] Amrenova A,Suzuki K,Saenko V,et al.Cell competition between anaplastic thyroid cancer and normal thyroid follicular cells exerts reciprocal stress response defining tumor suppressive effects of normal epithelial tissue[J].PLoS One,2021,16(4):e249059.DOI:10.1371/journal.pone.0249059.
[26] Caillou B,Talbot M,Weyemi U,et al.Tumor-associated macrophages(TAMs)form an interconnected cellular supportive network in anaplastic thyroid carcinoma[J].PLoS One,2011,6(7):e22567.DOI:10.1371/journal.pone.0022567.
[27] Cunha LL,Marcello MA,Ward LS.The role of the inflammatory microenvironment in thyroid carcinogenesis[J].Endocr Relat Cancer,2014,21(3):R85-R103.DOI:10.1530/ERC-13-0431.
[28] Chalan P,Di Dalmazi G,Pani F,et al.Thyroid dysfunctions secondary to cancer immunotherapy[J].J Endocrinol Invest,2018,41(6):625-638.DOI:10.1007/s40618-017-0778-8.

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备注/Memo

备注/Memo:
通信作者:徐加杰,Email:xujiajie@hmc.edu.cn
更新日期/Last Update: 2023-01-30