[1]马思远,刘秉昆,石芳彬,等.维生素D在预防重症新型冠状病毒肺炎中的作用及价值[J].国际内分泌代谢杂志,2022,42(03):179-183.[doi:10.3760/cma.j.cn121383-20210329-03077]
　Ma Siyuan,Liu Bingkun,Shi Fangbin,et al.Roles of vitamin D in the prevention of severie COVID-19[J].International Journal of Endocrinology and Metabolism,2022,42(03):179-183.[doi:10.3760/cma.j.cn121383-20210329-03077]
点击复制

维生素D在预防重症新型冠状病毒肺炎中的作用及价值()
分享到：

《国际内分泌代谢杂志》[ISSN:1673-4157/CN:12-1383/R]

卷:
42
期数:
2022年03期
页码:
179-183
栏目:
综述
出版日期:
2022-05-20

文章信息/Info

Title:
Roles of vitamin D in the prevention of severie COVID-19
作者:
马思远1; 刘秉昆2; 石芳彬3; 邹文玉4
1潍坊医学院 261000; 2潍坊市益都中心医院心内科 261000; 3青岛大学附属医院病案管理中心 266000; 4山东大学齐鲁医学院,济南 250000
Author(s):
Ma Siyuan1;  Liu Bingkun2;  Shi Fangbin3;  Zou Wenyu4
1Weifang Medical University, Weifang 261000, China; 2Department of Cardiology, Yidu Central Hospital of Weifang, Weifang 261000, China; 3Medical Record Management Center, Affiliated Hospital of Qingdao University, Qingdao 266000, China; 4Cheeloo College of Medicine, Shandong University, Jinan 250000, China
关键词:
新型冠状病毒肺炎;  维生素D;  疾病预防
Keywords:
Corona virus disease-19;  Vitamin D;  Disease prevention
DOI:
10.3760/cma.j.cn121383-20210329-03077
摘要:
新型冠状病毒引起的全球卫生危机仍在继续,而且病毒不断发生变异,传播速度逐渐变快。既往研究表明,维生素D可以在调节免疫、抑制炎症、干预肾素-血管紧张素系统等方面发挥作用,而且低维生素D水平与新型冠状病毒肺炎(COVID-19)严重程度以及死亡率之间存在联系。因此维生素D在减轻COVID-19病情严重程度上具有一定价值。但是目前的临床研究还没有明确维生素D用于广泛人群预防重症新冠肺炎的最佳补充剂量,这仍需要进一步的基础和临床试验来探索。
Abstract:
Recently, COVID-19 is still considered to be a common health issue around the world and the virus continues to mutate to a faster form. Recent studies have shown that vitamin D is of great importance in reducing the severity of COVID-19. Vitamin D can modulate immunity, suppress inflammation and intervene in the renin-angiotensin system. And low vitamin D level is associated with COVID-19 severity and mortality. However, current clinical studies have not yet identified the optimal dose of vitamin D for the prevention of severe COVID-19; a lot of basic and clinical trials are needed to explore the optimal dose for severe COVID-19 prevention.

参考文献/References:

[1] Cherrie M,Clemens T,Colandrea C,et al.Ultraviolet A radiation and COVID-19 deaths in the USA with replication studies in England and Italy [J].Br J Dermatol,2021,185(2):363-370.DOI:10.1111/bjd.20093.
[2] Rhodes JM,Subramanian S,Laird E,et al.Perspective:Vitamin D deficiency and COVID-19 severity-plausibly linked by latitude,ethnicity,impacts on cytokines,ACE2 and thrombosis[J].J Intern Med,2021,289(1):97-115.DOI:10.1111/joim.13149.
[3] Ye K,Tang F,Liao X,et al.Does serum vitamin D level affect COVID-19 infection and its severity-a case-control study[J].J Am Coll Nutr,2021,40(8):724-731.DOI:10.1080/07315724.2020.1826005.
[4] Lu R,Zhao X,Li J,et al.Genomic characterisation and epidemiology of 2019 novel coronavirus:implications for virus origins and receptor binding[J].Lancet,2020,395(10224):565-574.DOI:10.1016/S0140-6736(20)30251-8.
[5] Sun P,Lu X,Xu C,et al.Understanding of COVID-19 based on current evidence[J].J Med Virol,2020,92(6):548-551.DOI:10.1002/jmv.25722.
[6] Paraskevis D,Kostaki EG,Magiorkinis G,et al.Full-genome evolutionary analysis of the novel corona virus(2019-nCoV)rejects the hypothesis of emergence as a result of a recent recombination event[J].Infect Genet Evol,2020,79:104212.DOI:10.1016/j.meegid.2020.104212.
[7] Jain SK,Parsanathan R.Can vitamin D and L-Cysteine Co-Supplementation reduce 25(OH)-Vitamin D deficiency and the mortality associated with COVID-19 in African Americans?[J].J Am Coll Nutr,2020,39(8):694-699.DOI:10.1080/07315724.2020.1789518.
[8] Glinsky GV.Tripartite combination of candidate pandemic mitigation agents:vitamin D,quercetin,and estradiol manifest properties of medicinal agents for targeted mitigation of the COVID-19 pandemic defined by Genomics-Guided tracing of SARS-CoV-2 targets in human cells[J].Biomedicines,2020,8(5):129.DOI:10.3390/biomedicines8050129.
[9] Nimer R,Khabour O,Swedan S,et al.The impact of vitamin and mineral supplements usage prior to COVID-19 infection on disease severity and hospitalization[J].Bosn J Basic Med Sci,2022.DOI:10.17305/bjbms.2021.7009.
[10] Nurminen V,Seuter S,Carlberg C.Primary vitamin D target genes of human monocytes[J].Front Physiol,2019,10:194.DOI:10.3389/fphys.2019.00194.
[11] Agier J,Efenberger M,Brzezińska-Baszczyk E.Cathelicidin impact on inflammatory cells[J].Cent Eur J Immunol,2015,40(2):225-235.DOI:10.5114/ceji.2015.51359.
[12] Schwalfenberg GK.A review of the critical role of vitamin D in the functioning of the immune system and the clinical implications of vitamin D deficiency[J] Mol Nutr Food Res,2011,55(1):96-108.DOI:10.1002/mnfr.201000174.
[13] Kroner Jde C,Sommer A,Fabri M.Vitamin D every day to keep the infection away?[J].Nutrients,2015,7(6):4170-4188.DOI:10.3390/nu7064170.
[14] Ferreira GB,van Etten E,Verstuyf A,et al.1,25-Dihydroxyvitamin D3 alters murine dendritic cell behaviour in vitro and in vivo[J].Diabetes Metab Res Rev,2011,27(8):933-941.DOI:10.1002/dmrr.1275.
[15] Heine G,Anton K,Henz BM,et al.1alpha,25-dihydroxyvitamin D3 inhibits anti-CD40 plus IL-4-mediated IgE production in vitro[J].Eur J Immunol,2002,32(12):3395-3404.DOI:10.1002/1521-4141(200212)32:12<3395::AID-IMMU3395>3.0.CO; 2-#.
[16] Aygun H.Vitamin D can reduce severity in COVID-19 through regulation of PD-L1[J].Naunyn Schmiedebergs Arch Pharmacol,2022,395(4):487-494.DOI:10.1007/s00210-022-02210-w.
[17] Levi M,van der Poll T.Coagulation and sepsis[J].Thromb Res,2017,149:38-44.DOI:10.1016/j.thromres.2016.11.007.
[18] Grant WB,Lahore H,McDonnell SL,et al.Evidence that Vitamin D supplementation could reduce risk of influenza and COVID-19 infections and deaths[J].Nutrients,2020,12(4):988.DOI:10.3390/nu12040988.
[19] Xu J,Yang J,Chen J,et al.Vitamin D alleviates lipopolysaccharide induced acute lung injury via regulation of the renin angiotensin system[J].Mol Med Rep,2017,16(5):7432-7438.DOI:10.3892/mmr.2017.7546.
[20] Annweiler G,Corvaisier M,Gautier J,et al.Vitamin D supplementation associated to better survival in hospitalized frail elderly COVID-19 patients:the GERIA-COVID Quasi-Experimental study[J].Nutrients,2020,12(11):3377.DOI:10.3390/nu12113377.
[21] Annweiler C,Hanotte B,Grandin de l'Eprevier C,et al.Vitamin D and survival in COVID-19 patients:a quasi-experimental study[J].J Steroid Biochem Mol Biol,2020,204:105771.DOI:10.1016/j.jsbmb.2020.105771.
[22] Vanegas-Cedillo PE,Bello-Chavolla OY,Ramírez-Pedraza N,et al.Serum vitamin D levels are associated with increased COVID-19 severity and mortality independent of Whole-Body and visceral adiposity[J].Front Nutr,2022,9:813485.DOI:10.3389/fnut.2022.813485.
[23] Ling SF,Broad E,Murphy R,et al.High-Dose cholecalciferol booster therapy is associated with a reduced risk of mortality in patients with COVID-19:a Cross-Sectional Multi-Centre observational study[J].Nutrients,2020,12(12):3799.DOI:10.3390/nu12123799.
[24] Ohaegbulam KC,Swalih M,Patel P,et al.Vitamin D supplementation in COVID-19 patients:a clinical case series[J].Am J Ther,2020,27(5):e485-e490.DOI:10.1097/MJT.0000000000001222.
[25] Sabico S,Enani MA,Sheshah E,et al.Effects of a 2-Week 5 000 IU versus 1 000 IU Vitamin D3 supplementation on recovery of symptoms in patients with mild to moderate Covid-19:a randomized clinical trial[J].Nutrients,2021,13(7):2170.DOI:10.3390/nu13072170.
[26] Laviano E,Sanchez Rubio M,González-Nicolás MT,et al.Association between preoperative levels of 25-hydroxyvitamin D and hospital-acquired infections after hepatobiliary surgery:A prospective study in a third-level hospital[J].PLoS One,2020,15(3):e0230336.DOI:10.1371/journal.pone.0230336.
[27] Kow CS,Hadi MA,Hasan SS.Vitamin D Supplementation in influenza and COVID-19 infections comment on:"Evidence that Vitamin D supplementation could reduce risk of influenza and COVID-19 infections and deaths"Nutrients 2020,12(4),988[J].Nutrients,2020,12(6):1626.DOI:10.3390/nu12061626.

相似文献/References:

[1]冯娟,夏维波.维生素D结合蛋白研究进展[J].国际内分泌代谢杂志,2016,36(03):209.[doi:10.3760/cma.j.issn.1673-4157.2016.03.17]
　Feng Juan,Xia Weibo.Research progress of vitamin D binding protein[J].International Journal of Endocrinology and Metabolism,2016,36(03):209.[doi:10.3760/cma.j.issn.1673-4157.2016.03.17]
[2]王涛,张洁,祁范范,等.不同糖耐量人群血清25(OH)D3水平 及与胰岛β细胞功能的关系[J].国际内分泌代谢杂志,2016,36(04):226.[doi:10.3760/cma.j.issn.1673-4157.2016.04.04]
　Wang Tao*,Zhang Jie,Qi Fanfan,et al.Relationship between serum 25(OH)D3 level and islet β cell function in individuals with different glucose tolerance[J].International Journal of Endocrinology and Metabolism,2016,36(03):226.[doi:10.3760/cma.j.issn.1673-4157.2016.04.04]
[3]袁昕 高四书 罗凯明 项守奎 华飞.维生素D缺乏对雌性大鼠糖脂代谢及卵巢 形态功能的影响[J].国际内分泌代谢杂志,2019,39(01):7.[doi:10.3760/cma.j.issn.1673-4157.2019.01.002]
　Yuan Xin,Gao Sishu,Luo Kaiming,et al.Effects of vitamin D deficiency on glucolipid metabolism, morphology and function of ovary in female rats[J].International Journal of Endocrinology and Metabolism,2019,39(03):7.[doi:10.3760/cma.j.issn.1673-4157.2019.01.002]
[4]张晓蕾 敖娜 都健.维生素D以肠道菌群为靶点治疗非酒精性脂肪性肝病的 研究进展[J].国际内分泌代谢杂志,2019,39(05):311.[doi:10.3760/cma.j.issn.1673-4157.2019.05.006]
　Zhang Xiaolei,Ao Na,Du Jian.Advances in the treatment of non-alcoholic fatty liver disease with vitamin D targeting intestinal flora[J].International Journal of Endocrinology and Metabolism,2019,39(03):311.[doi:10.3760/cma.j.issn.1673-4157.2019.05.006]
[5]宋利革,李静,康志强.雌激素和新型冠状病毒肺炎的相关性[J].国际内分泌代谢杂志,2020,40(06):382.[doi:10.3760/cma.j.cn121383-20200306-03014]
　Song Lige,Li Jing,Kang Zhiqiang.Correlation between estrogen and COVID-19[J].International Journal of Endocrinology and Metabolism,2020,40(03):382.[doi:10.3760/cma.j.cn121383-20200306-03014]
[6]李红涛,汤绍芳.应重视对新型冠状病毒肺炎患者活性维生素D的应用[J].国际内分泌代谢杂志,2020,40(06):386.[doi:10.3760/cma.j.cn121383-20200331-03088]
　Li Hongtao,Tang Shaofang.The importance of the application of active vitamin D in patients with COVID-19 should be emphasized[J].International Journal of Endocrinology and Metabolism,2020,40(03):386.[doi:10.3760/cma.j.cn121383-20200331-03088]
[7]迪丽清娜·迪力木拉提,张君宜,曲伸.肥胖对新型冠状病毒肺炎患者的影响[J].国际内分泌代谢杂志,2021,41(06):632.[doi:10.3760/cma.j.cn121383-20200706-07014]
　Diliqingna·Dilimulati,Zhang Junyi,Qu Shen..Effects of obesity on patients with COVID-19[J].International Journal of Endocrinology and Metabolism,2021,41(03):632.[doi:10.3760/cma.j.cn121383-20200706-07014]
[8]相萍萍 韦晓 刘超.新型冠状病毒肺炎与糖尿病:我们何去何从?[J].国际内分泌代谢杂志,2022,42(01):50.[doi:10.3760/cma.j.cn121383-20201116-11033]
　Xiang Pingping,Wei Xiao,Liu Chao..New coronavirus pneumonia and diabetes: Where shall we go?[J].International Journal of Endocrinology and Metabolism,2022,42(03):50.[doi:10.3760/cma.j.cn121383-20201116-11033]
[9]宋博,滕卫平.糖尿病不同降糖药物与新型冠状病毒肺炎的相关性研究进展[J].国际内分泌代谢杂志,2022,42(03):191.[doi:10.3760/cma.j.cn121383-20210326-03036]
　Song Bo,Teng Weiping..Research progress on the relationship between different hypoglycemic drugs and COVID-19 in diabetes mellitus[J].International Journal of Endocrinology and Metabolism,2022,42(03):191.[doi:10.3760/cma.j.cn121383-20210326-03036]

备注/Memo

备注/Memo:
通信作者:邹文玉,Email:wenyzou@163.com
更新日期/Last Update: 2022-05-10