[1]于冬妮,郭立新.骨骼肌内脂肪沉积对肌肉功能及代谢的影响[J].国际内分泌代谢杂志,2022,42(02):134-137.[doi:10.3760/cma.j.cn121383-20201221-12060]
 Yu Dongni,Guo Lixin..Effect of intramuscular fat on muscle function and metabolism[J].International Journal of Endocrinology and Metabolism,2022,42(02):134-137.[doi:10.3760/cma.j.cn121383-20201221-12060]
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骨骼肌内脂肪沉积对肌肉功能及代谢的影响()
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《国际内分泌代谢杂志》[ISSN:1673-4157/CN:12-1383/R]

卷:
42
期数:
2022年02期
页码:
134-137
栏目:
综述
出版日期:
2022-03-20

文章信息/Info

Title:
Effect of intramuscular fat on muscle function and metabolism
作者:
于冬妮郭立新
北京医院内分泌科 国家老年医学中心 中国医学科学院老年医学研究院 100730
Author(s):
Yu Dongni Guo Lixin.
Department of Endocrinology, Beijing Hospital National Center of Gerotology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing 100730, China
关键词:
肌肉内脂肪 肌肉功能 胰岛素抵抗
Keywords:
Intramuscular fat Muscle function Insulin resistance
DOI:
10.3760/cma.j.cn121383-20201221-12060
摘要:
肌肉内脂肪含量增加与肥胖、糖尿病等代谢性疾病、年龄增加、活动受限和创伤等密切相关。肌肉内游离脂肪酸可以使葡萄糖转运蛋白4易位,减少肌肉组织对葡萄糖的摄取和利用; 肌肉内脂肪释放炎性因子,加重胰岛素抵抗。此外,肌肉内脂肪的增加还严重影响肌肉的收缩功能,减少肌力,与肌少症密切相关。饮食、运动和药物均可影响肌肉内脂肪含量。探索减少肌肉内脂肪含量的新方法,对改善胰岛素抵抗和提高肌肉功能有重要意义,有利于糖尿病和肥胖症的防治。
Abstract:
Increased fat content in muscles is closely related to metabolic diseases such as obesity and diabetes, increasing age, restricted activity and trauma. Intramuscular free fatty acids can translocate glucose transporter 4, reducing the uptake and utilization of glucose by muscle tissue; intramuscular fat releases inflammatory factors and aggravates insulin resistance. In addition, the increase of intramuscular fat also seriously affects the contraction of muscles and reduces muscle strength, which is closely related to sarcopenia. Diet, exercise, and medications can all affect fat content in muscles. Exploring new ways to reduce fat content in muscles is of great significant to improve insulin resistance and muscle function, and is beneficial to the prevention and treatment of diabetes and obesity.

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备注/Memo

备注/Memo:
通信作者:郭立新,Email:glx1218@163.com
基金项目:北京医院院内课题项目(BJ-2019-162)
更新日期/Last Update: 2022-04-20