[1]李赫岩,滕卫平,单忠艳,等.内分泌腺体中磷酸二酯酶的分布及作用研究进展[J].国际内分泌代谢杂志,2022,42(02):129-133.[doi:10.3760/cma.j.cn121383-20201201-12003]
　Li Heyan,Teng Weiping,Shan Zhongyan,et al.Distribution and function of phosphodiesterases in endocrine glands[J].International Journal of Endocrinology and Metabolism,2022,42(02):129-133.[doi:10.3760/cma.j.cn121383-20201201-12003]
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内分泌腺体中磷酸二酯酶的分布及作用研究进展()
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《国际内分泌代谢杂志》[ISSN:1673-4157/CN:12-1383/R]

卷:
42
期数:
2022年02期
页码:
129-133
栏目:
综述
出版日期:
2022-03-20

文章信息/Info

Title:
Distribution and function of phosphodiesterases in endocrine glands
作者:
李赫岩; 滕卫平; 单忠艳; 毛金媛
中国医科大学附属第一医院内分泌与代谢病科,内分泌研究所,国家卫生健康委(共建)甲状腺疾病诊治重点实验室,沈阳 110001
Author(s):
Li Heyan;  Teng Weiping;  Shan Zhongyan;  Mao Jinyuan.
Department of Endocrinology and Metabolism, Institute of Endocrinology, NHC Key Laboratory of Diagnosis and Treatment of Thyroid Diseases, the First Hospital of China Medical University, Shenyang 110001, China
关键词:
磷酸二酯酶;  内分泌腺体;  环磷酸腺苷;  蛋白激酶A;  基因多态性
Keywords:
Phosphodiesterase;  Endocrine glands;  cAMP;  Protein kinase A;  Gene polymorphism
DOI:
10.3760/cma.j.cn121383-20201201-12003
摘要:
磷酸二酯酶(PDEs)是细胞内的一类水解酶家族,可催化细胞内环磷酸腺苷(cAMP)和环磷酸鸟苷(cGMP)的水解,分别产生5'-单磷酸腺苷(5'-AMP)和5'-单磷酸鸟苷(5'-GMP),它们作为cAMP及cGMP细胞内浓度及生物学效应的关键调控因子,在多分子信号/调控复合物信号体的形成和功能中起着重要作用。因此,PDEs通过控制细胞内信号传导途径可以调控许多病理生理变化,参与癌症、炎症、神经退行性疾病和内分泌失调等过程。本综述对PDEs在内分泌腺体中的分布及作用进行阐述。
Abstract:
Phosphodiesterases(PDEs)is a family of hydrolytic enzyme in cells which can catalyze the hydrolysis of intracellular cAMP and cGMP to produce 5'-AMP and 5'-GMP, respectively. As the key regulators of cAMP/cGMP intracellular concentration and biological effects, PDEs play an important role in the formation and function of complex signaling molecules. Therefore, the intracellular signaling pathways controlled by PDEs can be altered in many pathological conditions and processes such as cancer, inflammation, neurodegenerative diseases and endocrine disorders. The review illustrates the distribution of expression and functions of PDEs in endocrine glands.

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备注/Memo

备注/Memo:
通信作者:毛金媛,Email:jinyuanmao@hotmail.com
基金项目:辽宁省高等学校创新人才支持计划(LR2019075); 辽宁省高等学校基本科研项目(LFWK201702)
更新日期/Last Update: 2022-04-20