[1]林露,徐向进.女性绝经期激素替代治疗的争议和共识[J].国际内分泌代谢杂志,2021,41(06):565-568.[doi:10.3760/cma.j.cn121383-20210915-09043]
 Lin Lu,Xu Xiangjin..Controversies and consensus on menopause hormone therapy in women during menopause[J].International Journal of Endocrinology and Metabolism,2021,41(06):565-568.[doi:10.3760/cma.j.cn121383-20210915-09043]
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女性绝经期激素替代治疗的争议和共识()
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《国际内分泌代谢杂志》[ISSN:1673-4157/CN:12-1383/R]

卷:
41
期数:
2021年06期
页码:
565-568
栏目:
专家论坛
出版日期:
2021-12-20

文章信息/Info

Title:
Controversies and consensus on menopause hormone therapy in women during menopause
作者:
林露徐向进
中国人民解放军联勤保障部队第900医院,福建医科大学福总临床医学院,福州 350025
Author(s):
Lin Lu Xu Xiangjin.
900 Hospital of the Joint Logistics Team, Fujian Medical University of Fuzong Clinical Medical College, Fuzhou 350025, China
关键词:
女性绝经期 激素替代治疗 争议与共识
Keywords:
Menopause Menopause hormone therapy Controversies and consensus
DOI:
10.3760/cma.j.cn121383-20210915-09043
摘要:
绝经期是女性生命中的一个重要且漫长的转变,可以引起骨质疏松等一系列临床症状,严重损害女性在该特殊时期的生活质量。激素替代治疗(MHT)可以有效改善女性绝经期的相关症状,是目前临床上主要的治疗方式。但许多研究认为,MHT可能增加乳腺癌等疾病的发生风险,导致MHT对绝经期女性的使用一度停滞不前。以科学辨证的态度正视MHT的利弊对于女性绝经期的管理至关重要。本文就女性绝经期MHT目前存在的争议和共识进行综述。
Abstract:
Menopause is an important and long transition in a woman's life, and causes a series of clinical symptoms such as osteoporosis, which seriously impairs a woman's quality of life during this special period. Menopause hormone therapy(MHT)can effectively improve the symptoms associated with menopause in women and is currently the main treatment modality. However, many studies have concluded that MHT may increase the risk of developing diseases such as breast cancer, leading to a stagnation in the use of MHT for menopausal women. A scientifically discriminating approach that confronts the pros and cons of MHT is essential for the management of women during menopause. This article reviews the current controversies and consensus on MHT for women during menopause.

参考文献/References:

[1] 中华医学会妇产科学分会绝经学组.绝经管理与绝经激素治疗中国指南(2018)[J].中华妇产科杂志,2018,53(11):729-739.DOI:10.3760/cma.j.issn.0529-567x.2018.11.001.
[2] Roberts H,Hickey M.Managing the menopause:an update[J].Maturitas,2016,86:53-58.DOI:10.1016/j.maturitas.2016.01.007.
[3] Harlow SD,Gass M,Hall JE,et al.Executive summary of the stages of reproductive aging workshop + 10:addressing the unfinished agenda of staging reproductive aging[J].J Clin Endocrinol Metab,2012,97(4):1159-1168.DOI:10.1210/jc.2011-3362.
[4] Hall JE.Endocrinology of the menopause[J].Endocrinol Metab Clin North Am,2015,44(3):485-496.DOI:10.1016/j.ecl.2015.05.010.
[5] Avis NE,Crawford SL,Greendale G,et al.Duration of menopausal vasomotor symptoms over the menopause transition[J].JAMA Intern Med,2015,175(4):531-539.DOI:10.1001/jamainternmed.2014.8063.
[6] Ren Y,Zhang M,Liu Y,et al.Association of menopause and type 2 diabetes mellitus[J].Menopause,2019,26(3):325-330.DOI:10.1097/GME.0000000000001200.
[7] de Villiers TJ,Hall JE,Pinkerton JV,et al.Revised global consensus statement on menopausal hormone therapy[J].Maturitas,2016,91:153-155.DOI:10.1016/j.maturitas.2016.06.001.
[8] Zhu D,Chung HF,Dobson AJ,et al.Vasomotor menopausal symptoms and risk of cardiovascular disease:a pooled analysis of six prospective studies[J].Am J Obstet Gynecol,2020,223(6):898.e1-898.e16.DOI:10.1016/j.ajog.2020.06.039.
[9] Lundberg G,Wu P,Wenger N.Menopausal hormone therapy:a comprehensive review[J].Curr Atheroscler Rep,2020,22(8):33.DOI:10.1007/s11883-020-00854-8.
[10] Santoro N,Komi J.Prevalence and impact of vaginal symptoms among postmenopausal women[J].J Sex Med,2009,6(8):2133-2142.DOI:10.1111/j.1743-6109.2009.01335.x.
[11] 彭红发,闫晓楠,徐春琳.绝经激素治疗与骨质疏松症[J].中国实用妇科与产科杂志,2020,36(3):230-233.DOI:10.19538/j.fk2020030112.
[12] Gordon JL,Girdler SS.Hormone replacement therapy in the treatment of perimenopausal depression[J].Curr Psychiatry Rep,2014,16(12):517.DOI:10.1007/s11920-014-0517-1.
[13] Slopien R,Wender-Ozegowska E,Rogowicz-Frontczak A,et al.Menopause and diabetes:EMAS clinical guide[J].Maturitas,2018,117:6-10.DOI:10.1016/j.maturitas.2018.08.009.
[14] Anderson GL,Limacher M,Assaf AR,et al.Effects of conjugated equine estrogen in postmenopausal women with hysterectomy:the Women's Health Initiative randomized controlled trial[J].JAMA,2004,291(14):1701-1712.DOI:10.1001/jama.291.14.1701.
[15] Manson JE,Aragaki AK,Rossouw JE,et al.Menopausal hormone therapy and long-term all-cause and cause-specific mortality:the women's health initiative randomized trials[J].JAMA,2017,318(10):927-938.DOI:10.1001/jama.2017.11217.
[16] Prabakaran S,Schwartz A,Lundberg G.Cardiovascular risk in menopausal women and our evolving understanding of menopausal hormone therapy:risks,benefits,and current guidelines for use[J].Ther Adv Endocrinol Metab,2021,12:20420188211013917.DOI:10.1177/20420188211013917.
[17] Collaborative Group on Hormonal Factors in Breast Cancer.Type and timing of menopausal hormone therapy and breast cancer risk:individual participant meta-analysis of the worldwide epidemiological evidence[J].Lancet,2019,394(10204):1159-1168.DOI:10.1016/S0140-6736(19)31709-X.
[18] de Villiers TJ,Hall JE,Pinkerton JV,et al.Revised global consensus statement on menopausal hormone therapy[J].Maturitas,2016,91:153-155.DOI:10.1016/j.maturitas.2016.06.001.
[19] Kotsopoulos J,Gronwald J,Karlan BY,et al.Hormone replacement therapy after oophorectomy and breast cancer risk among BRCA1 mutation carriers[J].JAMA Oncol,2018,4(8):1059-1065.DOI:10.1001/jamaoncol.2018.0211.
[20] Stute P,Wildt L,Neulen J.The impact of micronized progesterone on breast cancer risk:a systematic review[J].Climacteric,2018(2):111-122.DOI:10.1080/13697137.2017.1421925.

备注/Memo

备注/Memo:
通信作者:徐向进,Email:xu98111@163.com
更新日期/Last Update: 2021-12-10