[1]虞睿琪,肖新华.胰腺炎后糖尿病的诊治难点[J].国际内分泌代谢杂志,2021,41(06):562-564,582.[doi:10.3760/cma.j.cn121383-20211012-10024]
 Yu Ruiqi,Xiao Xinhua..Difficulties in diagnosis and treatment of post-pancreatitis diabetes mellitus[J].International Journal of Endocrinology and Metabolism,2021,41(06):562-564,582.[doi:10.3760/cma.j.cn121383-20211012-10024]
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胰腺炎后糖尿病的诊治难点()
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《国际内分泌代谢杂志》[ISSN:1673-4157/CN:12-1383/R]

卷:
41
期数:
2021年06期
页码:
562-564,582
栏目:
专家论坛
出版日期:
2021-12-20

文章信息/Info

Title:
Difficulties in diagnosis and treatment of post-pancreatitis diabetes mellitus
作者:
虞睿琪肖新华
中国医学科学院,北京协和医学院,北京协和医院内分泌科,国家卫生健康委员会内分泌重点实验室 100730
Author(s):
Yu Ruiqi Xiao Xinhua.
Department of Endocrinology, Key Laboratory of Endocrinology, National Health Commission of the People's Republic of China, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100730, China
关键词:
胰腺炎后糖尿病 慢性胰腺炎 胰腺外分泌功能不全
Keywords:
Post-pancreatitis diabetes mellitus Chronic pancreatitis Pancreatic exocrine insufficiency
DOI:
10.3760/cma.j.cn121383-20211012-10024
摘要:
胰腺炎后糖尿病(PPDM)指继发于急性或者慢性胰腺炎的糖尿病,因临床诊断困难,常被误诊为2型糖尿病。PPDM患者具有血糖波动性大、低血糖风险高、伴有胰腺外分泌功能不全的特点。治疗上除需根据血糖水平、胰岛功能及营养状况制定个体化降糖方案外,还需治疗胰腺外分泌功能不全并防治胰腺癌等并发症。其中,PPDM诊断方法的优化、口服降糖药的选择等均是临床诊疗中的难点。现结合近年来国内外研究和笔者的临床实践,对PPDM的诊治难点进行总结,以供参考。
Abstract:
Diabetes following pancreatitis termed post-pancreatitis diabetes mellitus(PPDM), which is characterized by high glycemic fluctuation, higher incidence of hypoglycemia and pancreatic exocrine insufficiency, often misdiagnosed as type 2 diabetes due to diagnostic difficulties. In addition to individualized hypoglycemic program based on blood glucose, islet function and nutritional status, treatment of pancreatic exocrine insufficiency and prevention of complications such as pancreatic cancer are also required. The diagnosis of diabetes after pancreatitis and the choice of oral hypoglycemic drugs are the difficulties in clinical practice. This review summarizes the difficulties mentioned above based on our actual experience and domestic and foreign studies for reference.

参考文献/References:

[1] Petrov MS.Diabetes of the exocrine pancreas:American Diabetes Association-compliant lexicon[J].Pancreatology,2017,17(4):523-526.DOI:10.1016/j.pan.2017.06.007.
[2] Das SL,Singh PP,Phillips AR,et al.Newly diagnosed diabetes mellitus after acute pancreatitis:a systematic review and meta-analysis[J].Gut,2014,63(5):818-831.DOI:10.1136/gutjnl-2013-305062.
[3] Petrov MS,Yadav D.Global epidemiology and holistic prevention of pancreatitis[J].Nat Rev Gastroenterol Hepatol,2019,16(3):175-184.DOI:10.1038/s41575-018-0087-5.
[4] Soo DHE,Pendharkar SA,Jivanji CJ,et al.Derivation and validation of the prediabetes self-assessment screening score after acute pancreatitis(PERSEUS)[J].Dig Liver Dis,2017,49(10):1146-1154.DOI:10.1016/j.dld.2017.05.021.
[5] 项坤三.胰腺病与糖尿病//项坤三,主编.特殊类型糖尿病[M].上海:上海科学技术出版社,2011:155-159.
[6] Wang W,Guo Y,Liao Z,et al.Occurrence of and risk factors for diabetes mellitus in Chinese patients with chronic pancreatitis[J].Pancreas,2011,40(2):206-212.DOI:10.1097/mpa.0b013e31820032ae.
[7] Meier JJ,Giese A.Diabetes associated with pancreatic diseases[J].Curr Opin Gastroenterol,2015,31(5):400-406.DOI:10.1097/MOG.0000000000000199.
[8] Rickels MR,Bellin M,Toledo FG,et al.Detection,evaluation and treatment of diabetes mellitus in chronic pancreatitis:recommendations from PancreasFest 2012[J].Pancreatology,2013,13(4):336-342.DOI:10.1016/j.pan.2013.05.002.
[9] Meier JJ,Breuer TG,Bonadonna RC,et al.Pancreatic diabetes manifests when beta cell area declines by approximately 65% in humans[J].Diabetologia,2012,55(5):1346-1354.DOI:10.1007/s00125-012-2466-8.
[10] Ewald N,Hardt PD.Diagnosis and treatment of diabetes mellitus in chronic pancreatitis[J].World J Gastroenterol,2013,19(42):7276-7281.DOI:10.3748/wjg.v19.i42.7276.
[11] Ewald N,Bretzel RG.Diabetes mellitus secondary to pancreatic diseases(type 3c)--are we neglecting an important disease[J].Eur J Intern Med,2013,24(3):203-206.DOI:10.1016/j.ejim.2012.12.017.
[12] Petrov MS,Basina M.Diagnosis of endocrine disease:diagnosing and classifying diabetes in diseases of the exocrine pancreas[J].Eur J Endocrinol,2021,184(4):R151-R163.DOI:10.1530/EJE-20-0974.
[13] Woodmansey C,McGovern AP,McCullough KA,et al.Incidence,demographics,and clinical characteristics of diabetes of the exocrine pancreas(type 3c):a retrospective cohort study[J].Diabetes Care,2017,40(11):1486-1493.DOI:10.2337/dc17-0542.
[14] Cui Y,Andersen DK.Pancreatogenic diabetes:special considerations for management[J].Pancreatology,2011,11(3):279-294.DOI:10.1159/000329188.
[15] Cho J,Scragg R,Petrov MS.Postpancreatitis diabetes confers higher risk for pancreatic cancer than type 2 diabetes:results from a nationwide cancer registry[J].Diabetes Care,2020,43(9):2106-2112.DOI:10.2337/dc20-0207.

备注/Memo

备注/Memo:
通信作者:肖新华, Email:xiaoxh2014@vip.163.com
更新日期/Last Update: 2021-12-10