[1]林金丹,闫爽.外泌体在脂肪分化与脂代谢中作用的研究进展[J].国际内分泌代谢杂志,2020,40(05):335-339.[doi:10.3760/cma.j.cn121383-20200101-01004]
 Lin Jindan,Yan Shuang.Research progress of the effects of exosomes on adipogenic differentiation and lipid metabolism[J].International Journal of Endocrinology and Metabolism,2020,40(05):335-339.[doi:10.3760/cma.j.cn121383-20200101-01004]
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外泌体在脂肪分化与脂代谢中作用的研究进展()
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《国际内分泌代谢杂志》[ISSN:1673-4157/CN:12-1383/R]

卷:
40
期数:
2020年05期
页码:
335-339
栏目:
综述
出版日期:
2020-09-20

文章信息/Info

Title:
Research progress of the effects of exosomes on adipogenic differentiation and lipid metabolism
作者:
林金丹闫爽
哈尔滨医科大学附属第四医院内分泌代谢科 150001
Author(s):
Lin Jindan Yan Shuang
Department of Endocrinology and Metabolism, The Fourth Affiliated Hospital of Harbin Medical University, Harbin 150001, China
关键词:
外泌体 肥胖 脂肪分化 脂代谢 脂肪细胞
Keywords:
Exosomes Obesity Adipogenic differentiation Lipid metabolism Adipocyte
DOI:
10.3760/cma.j.cn121383-20200101-01004
文献标志码:
A
摘要:
外泌体是体液中一种由多种细胞分泌的直径为30~200 nm的微小囊泡。它以旁分泌或内分泌方式起作用,通过膜融合、内吞等作用机制,介导细胞信号传递,进而影响细胞间通讯,在多种生物学过程中发挥至关重要的作用。研究发现,外泌体能够通过调控脂肪分化特异基因、脂肪生成相关酶等因子的表达,介导细胞外信号调节激酶信号通路等作用机制,参与调节脂肪分化及脂肪代谢。外泌体能够反映肥胖及相关代谢性疾病的病情,是参与诊断和治疗肥胖的潜在指标及靶点之一,具有重要的临床价值。
Abstract:
Exosomes is a kind of microvesicles with diameter of 30-200 nm secreted by many kinds of cells in body fluid. It acts in paracrine or endocrine ways, mediates cell signal transmission through mechanisms such as membrane fusion and endocytosis, then affects intercellular communication and plays a vital role in a variety of biological processes. Studies have found that exosomes can participate in the regulation of adipogenic differentiation and lipid metabolism by regulating the expression of adipose differentiation-specific genes, lipogenesis-related enzymes and other factors, as well as mediating extracellular signal-regulated kinases signal pathway and other mechanisms. Exosomes can reflect the condition of obesity and related metabolic diseases, and is one of the potential indicators and targets to participate in the diagnosis and treatment of obesity, and has important clinical value.

参考文献/References:

[1] Upadhyay J, Farr O, Perakakis N, et al.Obesity as a disease[J].Med Clin North Am,2018,102(1):13-33.DOI:10.1016/j.mcna.2017.08.004.
[2] Zhang J, Li S, Li L, et al.Exosome and exosomal microRNA: trafficking, sorting, and function[J].Genomics Proteomics Bioinformatics,2015,13(1):17 -24.DOI:10.1016/j.gpb.2015.02.001.
[3] Urbanelli L, Magini A, Buratta S, et al. Signaling pathways in exosomes biogenesis, secretion and fate[J].Genes(Basel),2013,4(2):152-170. DOI:10.3390/genes4020152.
[4] Pegtel DM, Gould SJ. Exosomes[J].Annu Rev Biochem,2019,88:487-514.DOI:10.1146/annurev-biochem-013118-111902.
[5] Farooqi AA, Desai NN, Qureshi MZ, et al.Exosome biogenesis, bioactivities and functions as new delivery systems of natural compounds [J].Biotechnol Adv,2018,36(1):328-334.DOI:10.1016/j.biotechadv.2017.12.010.
[6] Zhang Y, Liu Y, Liu H, et al. Exosomes:biogenesis, biologic function and clinical potential[J].Cell Biosci,2019,9:19.DOI:10.1186/s13578-019-0282 -2.
[8] Chen Q, Shou P, Zheng C, et al.Fate decision of mesenchymal stem cells: adipocytes or osteoblasts[J].Cell Death Differ,2016,23(7):1128- 1139.DOI:10.1038/cdd.2015.168.
[9] Wang S, Li X, Xu M, et al.Reduced adipogenesis after lung tumor exosomes priming in human mesenchymal stem cells via TGFβ signaling pathway [J].Mol Cell Biochem,2017,435(1-2):59-66.DOI:10.1007/s11010-017-3056-3.
[10] Wan Z, Chen X, Gao X, et al. Chronic myeloid leukemia-derived exosomes attenuate adipogenesis of adipose derived mesenchymal stem cells via transporting miR-92a-3p[J].J Cell Physiol,2019,234(11):21274-21283.DOI:10.1002/jcp.28732.
[11] Kyoung S, In J, Seong H, et al. Exosomes secreted during adipogenic differentiation of human adipose-derived stem cells induce adipogenesis of human adipose-derived stem cells[J].J Extracell Vesicles, 2015,4:27783.DOI:http://dx.doi.org/10.3402/jev.v4.27783[Abstract P-XIV-2].
[12] Narayanan K, Kumar S, Padmanabhan P, et al.Lineage-specific exosomes could override extracellular matrix mediated human mesenchymal stem cell differentiation[J].Biomaterials,2018,182:312-322.DOI:10.1016/j.biomaterials.2018.08.027.
[13] Zhang Y, Yu M, Dai M, et al.miR-450a-5p within rat adipose tissue exosome-like vesicles promotes adipogenic differentiation by targeting WISP2 [J].J Cell Sci,2017,130(6):1158-1168.DOI:10.1242/jcs.197764.
[14] Dai M, Yu M, Zhang Y, et al.Exosome-like vesicles derived from adipose tissue provide biochemical cues for adipose tissue regeneration[J].Tissue Eng Part A,2017,23(21-22):1221-1230.DOI:10.1089/ten.TEA.2017.0045.
[15] De Silva N, Samblas M, Martínez JA, et al.Effects of exosomes from LPS-activated macrophages on adipocyte gene expression, differentiation, and insulin-dependent glucose uptake[J].J Physiol Biochem,2018,74(4):559-568.DOI: 10.1007/s13105-018-0622-4.
[16] Zhao H, Shang Q, Pan Z, et al.Exosomes from adipose-derived stem cells attenuate adipose inflammation and obesity through polarizing M2 macrophages and beiging in white adipose tissue[J].Diabetes,2018,67(2):235-247.DOI:10.2337/db17-0356.
[17] Zhang B, Yang Y, Xiang L, et al.Adipose-derived exosomes:a novel adipokine in obesity-associated diabetes[J].J Cell Physiol,2019,234(10):16692- 16702.DOI:10.1002/jcp.28354.
[18] Chen Y, Siegel F, Kipschull S, et al.miR-155 regulates differentiation of brown and beige adipocytes via a bistable circuit[J].Nat Commun,2013,4:1769.DOI:10.1038/ncomms2742.
[19] Ertunc ME, Sikkeland J, Fenaroli F, et al.Secretion of fatty acid binding protein aP2 from adipocytes through a nonclassical pathway in response to adipocyte lipase activity[J].J Lipid Res,2015,56(2):423-434.DOI:10.1194/jlr.M055798.
[20] Sano S, Izumi Y, Yamaguchi T, et al.Lipid synthesis is promoted by hypoxic adipocyte-derived exosomes in 3T3-L1 cells[J].Biochem Biophys Res Commun,2014,445(2):327-333.DOI:10.1186/s13046-019-1210-3.
[21] Khalyfa A, Gozal D, Masa JF, et al.Sleep-disordered breathing, circulating exosomes, and insulin sensitivity in adipocytes[J].Int J Obes (Lond),2018,42(6):1127-1139.DOI:10.1038/s41366-018-0099-9.
[22] Inokawa A, Inuzuka T, Takahara T, et al.Tubby-like protein superfamily member PLSCR3 functions as a negative regulator of adipogenesis in mouse 3T3-L1 preadipocytes by suppressing induction of late differentiation stage transcription factors[J].Biosci Rep,2015,36 (1):e00287.DOI:10.1042/BSR20150215.
[23] Lazar I, Clement E, Dauvillier S, et al. Adipocyte exosomes promote melanoma aggressiveness through fatty acid oxidation: a novel mechanism linking obesity and cancer[J].Cancer Res, 2016,76(14):4051-4057.DOI:10.1158/0008-5472.CAN-16-0651.
[24] Flaherty SE, Grijalva A, Xu X, et al.A lipase-independent pathway of lipid release and immune modulation by adipocytes[J].Science,2019,363 (6430):989-993.DOI:10.1126/science.aaw2586.
[25] Castaño C, Kalko S, Novials A, et al.Obesity-associated exosomal miRNAs modulate glucose and lipid metabolism in mice[J].Proc Natl Acad Sci U S A,2018,115(48):12158-12163.DOI:10.1073/pnas.1808855115.
[26] Kim MS, Muallem S, Kim SH, et al.Exosomal release through TRPML1-mediated lysosomal exocytosis is required for adipogenesis[J].Biochem Biophys Res Commun,2019,510(3):409-415.DOI:10.1016/j.bbrc.2019.01.115.
[27] Wu J, Dong T, Chen T, et al.Hepatic exosome-derived miR-130a-3p attenuates glucose intolerance via suppressing PHLPP2 gene in adipocyte [J].Metabolism,2019,103:154006.DOI:10.1016/j.metabol.2019.154006.
[28] Hu W, Ru Z, Xiao W, et al.Adipose tissue browning in cancer-associated cachexia can be attenuated by inhibition of exosome generation[J].Biochem Biophys Res Commun,2018,506(1):122-129.DOI:10.1016/j.bbrc.2018.09.139.
[29] Zhang H, Zhu L, Bai M, et al.Exosomal circRNA derived from gastric tumor promotes white adipose browning by targeting the miR-133/PRDM16 pathway [J].Int J Cancer,2019,144(10):2501-2515.DOI:10.1002/ijc.31977.
[30] Wu Q, Li J, Li Z, et al.Exosomes from the tumour-adipocyte interplay stimulate beige/brown differentiation and reprogram metabolism in stromal adipocytes to promote tumour progression[J].J Exp Clin Cancer Res,2019,38(1):223.DOI:10.1186/s13046-019-1210-3.
[31] Wang L, Zhang B, Zheng W, et al.Exosomes derived from pancreatic cancer cells induce insulin resistance in C2C12 myotube cells through the PI3K/Akt/FoxO1 pathway[J].Sci Rep,2017,7(1):5384.DOI:10.1038/s41598-017-05541-4.
[32] Sagar G, Sah RP, Javeed N, et al.Pathogenesis of pancreatic cancer exosome-induced lipolysis in adipose tissue[J].Gut,2016,65(7):1165- 1174.DOI:10.1136/gutjnl-2014-308350.
[33] Kong F, Li L, Du Y, et al.Exosomal adrenomedullin derived from cancer-associated fibroblasts promotes lipolysis in adipose tissue[J].Gut,2018,67 (12):2226-2227.DOI:10.1136/gutjnl-2017-315778.
[34] Zhang Y, Yu M, Tian W.Physiological and pathological impact of exosomes of adipose tissue[J].Cell Prolif,2016,49(1):3-13.DOI:10.1111/cpr.12233.
[35] Cianciaruso C, Phelps EA, Pasquier M, et al.Primary human and rat β-cells release the intracellular autoantigens GAD65, IA-2, and proinsulin in exosomes together with cytokine-induced enhancers of immunity[J].Diabetes,2017,66(2):460-473.DOI:10.2337/db16-0671.

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备注/Memo

备注/Memo:
基金项目:中国健康促进基金会资助研究项目(CHPF-2017-LXSCD) 通信作者:闫爽,Email:qingmei0724@163.com
更新日期/Last Update: 2020-09-20