[1]孙梅 刘栩晗 王冰 高政南.吸烟与中老年糖尿病患者视网膜病变的 相关性研究[J].国际内分泌代谢杂志,2020,40(04):223-227.[doi:10.3760/cma.j.issn.1673-4157.2020.04.002]
　Sun Mei,Liu Xuhan,Wang Bing,et al.Study on the correlation between smoking and diabetic retinopathy in middle-age and old people[J].International Journal of Endocrinology and Metabolism,2020,40(04):223-227.[doi:10.3760/cma.j.issn.1673-4157.2020.04.002]
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吸烟与中老年糖尿病患者视网膜病变的 相关性研究
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《国际内分泌代谢杂志》[ISSN:1673-4157/CN:12-1383/R]

卷:
40
期数:
2020年04期
页码:
223-227
栏目:
论著
出版日期:
2020-07-20

文章信息/Info

Title:
Study on the correlation between smoking and diabetic retinopathy in middle-age and old people
作者:
孙梅1 刘栩晗2 王冰2 高政南2
1锦州医科大学附属第一医院内分泌科 121012; 2大连医科大学附属大连市中心医院内分泌科 116044
Author(s):
Sun Mei1;  Liu Xuhan2;  Wang Bing2;  Gao Zhengnan2
1Department of Endocrinology, The First Affiliated Hospital of Jinzhou Medical University, Jinzhou 121012, China; 2Department of Endocrinology, Dalian Municipal Central Hospital Affiliated of Dalian Medical University, Dalian 116044, China
关键词:
吸烟;  糖尿病视网膜病变;  2型糖尿病
Keywords:
Cigarette smoking;  Diabetic retinopathy;  Type 2 diabetes mellitus
DOI:
10.3760/cma.j.issn.1673-4157.2020.04.002
摘要:
目的 研究吸烟与中老年2型糖尿病(T2DM)患者糖尿病视网膜病变(DR)的相关性。方法 选取 2 188例大连地区年龄大于等于40周岁的T2DM患者进行研究,并对其各项生理生化指标进行检测,同时采集其年龄、性别、吸烟情况等基本信息,3年后对此人群进行随访、整理,分析其基线及随访的各项检查及问卷调查结果,采用Cox回归模型评估吸烟对DR发生、进展及增殖期糖尿病视网膜病变(PDR)发生的影响。结果 不同吸烟状态下中老年人DR发生率(χ2=11.318,P=0.010)和DR进展率(χ2=9.790,P=0.020)存在差异。与不吸烟组相比,戒烟组人群DR发生率显著降低(P<0.05)。戒烟组与被动吸烟组DR进展率差异显著(P<0.05)。男性戒烟组DR发生率显著低于男性不吸烟组和被动吸烟组(P均<0.05)。与不吸烟组相比,女性主动吸烟组、被动吸烟组及戒烟组DR发生率、DR进展率及PDR发生率均无统计学差异。结论 不同吸烟状态与中老年人DR发生、DR进展有关,与PDR发生无关,戒烟是男性DR发生的独立保护因素,戒烟与女性DR发生无关。
Abstract:
Objective To investigate the correlation between cigarette smoking and diabetic retinopathy(DR)in middle aged and elderly patients with type 2 diabetes mellitus(T2DM).Methods A total of 2 188 patients with T2DM aged 40 years or older in Dalian were selected for the study, and various physiological and biochemical indicators of these patients were detected, while age, gender, smoking status and other basic information were collected. Three years later, the patients were followed up, and their baseline and follow-up examinations and questionnaire results were sorted out and analyzed. Cox regression model was used to evaluate the influence of smoking on the occurrence of DR and proliferative diabetic retnopathy, progression of DR.Results There were statistically significant differences in the incidence of DR(χ2=11.318, P=0.010)and the progression rate of DR(χ2=9.790, P=0.020). Compared with non-smoking group, the incidence of DR in the smoking cessation group was significantly lower(P<0.05). There was significant difference in DR progression rate between smoking cessation group and passive smoking group(P<0.05). The incidence of DR in male smoking cessation group was significantly lower than that in male non-smoking group and passive smoking group(P<0.05). Compared with non-smoking group, there were no statistically significant differences in the incidence of DR, DR progression rate and PDR in the female active smoking group, passive smoking group and smoking cessation group.Conclusions Different smoking status is related to the occurrence and progression of DR in middle-aged and old people, but has no association with the occurrence of PDR. Smoking cessation is an independent protective factor for the occurrence of DR in men, but not in women.

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备注/Memo

备注/Memo:
通信作者:高政南,Email:gao2008@163.com
基金项目:国家重点基础研究发展计划(973计划)(2016YFC0901200)
Corresponding author: Gao Zhengnan, Email: gao2008@163.com
Fund program:National Key Basic Research and Development Program(973Program)(2016YFC0901200)
更新日期/Last Update: 2020-07-20