[1]贺琼 薄佳琪 张咪 白春梅 刘子昂 刘云峰.1-磷酸鞘氨醇对糖尿病血管内皮功能障碍的 调节作用及机制[J].国际内分泌代谢杂志,2020,40(03):211-214.[doi:10.3760/cma.j.issn.1673-4157.2020.03.015]
　He Qiong,Bo Jiaqi,Zhang Mi,et al.Regulation and mechanism of sphingosine-1-phosphate on dysfunction of diabetic vascular endothelial cells[J].International Journal of Endocrinology and Metabolism,2020,40(03):211-214.[doi:10.3760/cma.j.issn.1673-4157.2020.03.015]
点击复制

1-磷酸鞘氨醇对糖尿病血管内皮功能障碍的 调节作用及机制()
分享到：

《国际内分泌代谢杂志》[ISSN:1673-4157/CN:12-1383/R]

卷:
40
期数:
2020年03期
页码:
211-214
栏目:
基础研究
出版日期:
2020-05-20

文章信息/Info

Title:
Regulation and mechanism of sphingosine-1-phosphate on dysfunction of diabetic vascular endothelial cells
作者:
贺琼1; 2 薄佳琪1 张咪1 白春梅1 刘子昂3 刘云峰2
1山西医科大学,太原 030001; 2山西医科大学第一医院内分泌科,太原 030001; 3山西医科大学第一临床医学院
Author(s):
He Qiong1; 2;  Bo Jiaqi1;  Zhang Mi1;  Bai Chunmei1;  Liu Ziang3;  Liu Yunfeng2
1Shanxi Medical University, Taiyuan 030001, China; 2Department of Endocrinology, The First Hospital of Shanxi Medical University, Taiyuan 030001, China; 3The First Medical College of Shanxi Medical University, Taiyuan 030001, China
关键词:
1-磷酸鞘氨醇;  血管内皮功能障碍;  糖尿病
Keywords:
Sphingosine-1-phosphate;  Vascular endothelial dysfunction;  Diabetes mellitus
DOI:
10.3760/cma.j.issn.1673-4157.2020.03.015
摘要:
多种糖尿病并发症的共同基础是血管内皮功能障碍(VED)。高血糖对血管内皮的糖毒性损伤包括诱导内皮细胞凋亡、阻碍正常血管内皮收缩、舒张功能和增加血管通透性。现有研究表明,1-磷酸鞘氨醇(S1P)具有维持细胞正常生命周期、缓解血管内皮功能障碍、稳定血管通透性的效果。S1P可以通过复杂分子机制改善VED,进而有效预防和控制糖尿病血管并发症。明确上述调节作用及具体机制有助于研发治疗靶点,防治糖尿病血管并发症。
Abstract:
The common basis for a variety of diabetic complications is vascular endothelial dysfunction(VED). The cytotoxic effect of hyperglycemia on vascular endothelium is induced by inducing apoptosis of endothelial cells, impeding systolic and diastolic function of normal vascular endothelium, and increasing vascular permeability. Existing studies have shown that sphingosine-1-phosphate(S1P)has the effect of maintaining normal cell life cycle, improving vascular endothelial dysfunction and regulating vascular permeability. S1P can improve VED through complex mechanisms to effectively prevent and control diabetic vascular complications. Identifying specific effects and mechanisms will help to develop targets, and to prevent and treat diabetic vascular complications.

参考文献/References:

[1] Wang L,Gao P,Zhang M,et al.Prevalence and ethnic pattern of diabetes and prediabetes in China in 2013[J].JAMA,2017,317(24):2515-2523.DOI:10.1001/jama.2017.7596.
[2] Blaho VA,Hla T.Regulation of mammalian physiology, development, and disease by the sphingosine 1-phosphate and lysophosphatidic acid receptors[J].Chem Rev,2011,111(10):6299-6320.DOI:10.1021/cr200273u.
[3] 黄祺,程海燕,卜瑞芳.1-磷酸鞘胺醇与胰岛素抵抗[J].国际内分泌代谢杂志, 2015, 35(5):348-350.DOI:10.3760/cma.j.issn.1673-4157.2015.05.015.
[4] Ishibashi Y,Matsui T,Ueda S,et al.Advanced glycation end products potentiate citrated plasma-evoked oxidative and inflammatory reactions in endothelial cells by up-regulating protease-activatedreceptor-1 expression[J].Cardiovasc Diabetol,2014,13:60.DOI:10.1186/1475-2840-13-60.
[5] Yang G,Huang Y,Wu X,et al.Endogenous secretory receptor for advanced glycation end products protects endothelial cells from AGEs induced apoptosis[J].Biomed Res Int,2018,2018:8216578.DOI:10.1155/2018/8216578.
[6] Adamopoulos C,Farmaki E,Spilioti E,et al.Advanced glycation end-products induce endoplasmic reticulum stress in humanaortic endothelial cells[J].Clin Chem Lab Med,2014,52(1):151-160.DOI:10.1515/cclm-2012-0826.
[7] Hong J,Kim K,Kim JH,et al.The role of endoplasmic reticulum stress in cardiovascular disease and exercise[J].Int J Vasc Med,2017,2017:2049217.DOI:10.1155/2017/2049217.
[8] 滕林,杨伟,周飞,等.内质网应激蛋白CHOP-10在缺血缺氧诱导人主动脉内皮细胞损伤中的作用[J].中国动脉硬化杂志,2016,24(3):245-250.
[9] Zha ZM,Wang JH,Li SL,et al.Pitavastatin attenuates AGEs-induced mitophagy via inhibition of ROS generation in the mitochondria of cardiomyocytes[J].J Biomed Res,2018,32(4):281-287.DOI:10.7555/JBR.31.20160116.
[10] Tong T,Liu Z,Zhang H,et al.Age-dependent expression of the vitamin D receptor and the protective effect of vitamin D receptor activation on H2O2-induced apoptosis in rat intervertebral disccells[J].J Steroid Biochem Mol Biol,2019,190:126-138.DOI:10.1016/j.jsbmb.2019.03.013.
[11] Wang H,Huang H,Ding SF.Sphingosine-1-phosphate promotes the proliferation and attenuates apoptosis of endothelial progenitor cells via S1PR1/S1PR3/PI3K/Akt pathway[J].Cell Biol Int,2018,42(11):1492-1502.DOI:10.1002/cbin.10991.
[12] Yu FC,Yuan CX,Tong JY,et al.Protective effect of sphingosine-1-phosphate for chronic intermittent hypoxia-induced endothelial cell injury[J].Biochem Biophys Res Commun,2018,498(4):1016-1021.DOI:10.1016/j.bbrc.2018.03.106.
[13] Taguchi Y,Allende ML,Mizukami H,et al.Sphingosine-1-phosphate phosphatase 2 regulates pancreatic islet β-cell endoplasmic reticulum stress and proliferation[J].J Biol Chem,2016,291(23):12029-12038.DOI:10.1074/jbc.M116.728170.
[14] Walter P,Ron D.The unfolded protein response: from stress pathway to homeostatic regulation[J].Science,2011,334(6059):1081-1086.DOI:10.1126/science.1209038.
[15] Lebeau P,Byun JH,Yousof T,et al.Pharmacologic inhibition of S1P attenuates ATF6 expression, causes ER stress and contributes to apoptotic cell death[J].Toxicol Appl Pharmacol,2018,349:1-7.DOI:10.1016/j.taap.2018.04.020.
[16] 任惠珠,周赛君.血管内皮细胞生长因子-一氧化氮轴与糖尿病肾病[J].国际内分泌代谢杂志, 2015, 35(5): 354-356.DOI:10.3760/cma.j.issn.1673-4157.2015.05.017.
[17] El Khoury N,Mathieu S,Fiset C.Interleukin-1β reduces L-type Ca2+ current through protein kinase C activation in mouse heart[J].J Biol Chem,2014,289(32):21896-21908.DOI:10.1074/jbc.M114.549642.
[18] Kizub IV,Klymenko KI,Soloviev AI. Protein kinase C in enhanced vascular tone in diabetes mellitus[J].Int J Cardiol,2014,174(2):230-242.DOI:10.1016/j.ijcard.2014.04.117.
[19] Tukijan F,Chandrakanthan M,Nguyen LN. The signalling roles of sphingosine-1-phosphate derived from red blood cells and platelets[J].Br J Pharmacol,2018,175(19):3741-3746.DOI:10.1111/bph.14451.
[20] Wang X,Zhan E,Lu G,et al.Sphingosine-1-phosphate improves the biological features of mouse bone marrow-derived EPCs partially through PI3K/AKT/eNOS/NO pathway[J].Molecules,2019,24(13):pii:E2404.DOI:10.3390/molecules24132404.
[21] Kamiya T,Nagaoka T,Omae T,et al.Role of Ca2+ -dependent and Ca2+ -sensitive mechanisms in sphingosine 1-phosphate-induced constriction of isolated porcine retinal arterioles in vitro[J].Exp Eye Res,2014,121:94-101.DOI:10.1016/j.exer.2014.01.011.
[22] Ringvold HC,Khalil RA.Protein kinase C as regulator of vascular smooth muscle function and potential target in vascular disorders[J].Adv Pharmacol,2017,78:203-301.DOI:10.1016/bs.apha.2016.06.002.
[23] Matafome P,Sena C,Seiça R.Methylglyoxal, obesity, and diabetes[J].Endocrine,2013,43(3):472-484.DOI:10.1007/s12020-012-9795-8.
[24] 侯沃霖,刘芳.糖尿病引起内皮祖细胞损伤机制研究进展[J].国际内分泌代谢杂志, 2013,33(3):192-194.DOI:10.3760/cma.j.issn.1673-4157.2013.03.014.
[25] Christoffersen C,Obinata H,Kumaraswamy SB,et al.Endothelium-protective sphingosine-1-phosphate provided by HDL-associated apolipoprotein M[J].Proc Natl Acad Sci U S A,2011,108(23):9613-9618.DOI:10.1073/pnas.1103187108.
[26] Schuchardt M,Tölle M,Prüfer J,et al.Pharmacological relevance and potential of sphingosine 1-phosphate in the vascularsystem[J].Br J Pharmacol,2011,163(6):1140-1162.DOI:10.1111/j.1476-5381.2011.01260.x.
[27] Herzog BH,Fu J,Wilson SJ,et al.Podoplanin maintains high endothelial venule integrity by interacting with platelet CLEC-2[J].Nature,2013,502(7469):105-109.DOI:10.1038/nature12501.
[28] Nishihara H,Shimizu F,Sano Y,et al.Fingolimod prevents blood-brain barrier disruption induced by the sera from patients with multiple sclerosis[J].PLoS One,2015,10(3):e0121488.DOI:10.1371/journal.pone.0121488.
[29] Xiao W,Sun L,Zhang N,et al.Adverse effect profile of topical ocular administration of fingolimod for treatment of dry eye disease[J].Basic Clin Pharmacol Toxicol,2017,120(4):398-406.DOI:10.1111/bcpt.12717.
[30] Wang Z,Sims CR,Patil NK,et al.Pharmacologic targeting of sphingosine-1-phosphate receptor 1 improves the renal microcirculation during sepsis in the mouse[J].J Pharmacol Exp Ther,2015,352(1):61-66.DOI:10.1124/jpet.114.219394.
[31] Egom EE,Mohamed TM,Mamas MA,et al.Activation of Pak1/Akt/eNOS signaling following sphingosine-1-phosphate release as part of a mechanism protecting cardiomyocytes against ischemic cell injury[J].Am J Physiol Heart Circ Physiol,2011,301(4):H1487-H1495.DOI:10.1152/ajpheart.01003.2010.

备注/Memo

备注/Memo:
通信作者:刘云峰,Email:nectarliu@163.com
基金项目:国家自然科学基金(81770776); 山西省大学生创新创业基金(2018165); 山西省自然科学基金面上项目(201901D111353)
Corresponding author: Liu Yunfeng, Email:nectarliu@163.com
Fund program:National Natural Science Foundation of China(81770776); Shanxi University Students Innovation and Entrepreneurship Fund(2018165); Natural Science Foundation of Shanxi Province(201901D111353)
更新日期/Last Update: 2020-05-20