[1]王珊珊 俞冰鸿 傅雯雯 杨艳辉 孔岩 王靖宇 常宝成 郑妙艳 杨菊红 王颖许杰 单春艳.亚临床甲状腺功能减退症与2型糖尿病肾功能损伤的相关性研究[J].国际内分泌代谢杂志,2019,39(06):368-372,376.[doi:10.3760/cma.j.issn.1673-4157.2019.06.002]
　Wang Shanshan,Yu Binghong,Fu Wenwen,et al.Correlation between subclinical hypothyroidism and renal function injury in patients with type 2 diabetes mellitus[J].International Journal of Endocrinology and Metabolism,2019,39(06):368-372,376.[doi:10.3760/cma.j.issn.1673-4157.2019.06.002]
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亚临床甲状腺功能减退症与2型糖尿病肾功能损伤的相关性研究()
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《国际内分泌代谢杂志》[ISSN:1673-4157/CN:12-1383/R]

卷:
39
期数:
2019年06期
页码:
368-372,376
栏目:
论著
出版日期:
2019-11-20

文章信息/Info

Title:
Correlation between subclinical hypothyroidism and renal function injury in patients with type 2 diabetes mellitus
作者:
王珊珊 俞冰鸿 傅雯雯 杨艳辉 孔岩 王靖宇 常宝成 郑妙艳 杨菊红 王颖许杰 单春艳
天津医科大学朱宪彝纪念医院肾内科,国家卫生健康委员会激素与发育重点实验室(天津医科大学),天津市代谢性疾病重点实验室,天津医科大学朱宪彝纪念医院&天津市内分泌研究所 300134
Author(s):
Wang Shanshan;  Yu Binghong;  Fu Wenwen;  Yang Yanhui;  Kong Yan;  Wang Jingyu;  Chang Baocheng;  Zheng Miaoyan;  Yang Juhong;  Wang Ying;  Xu Jie;  Shan Chunyan
Department of Nephrology, NHC Key Laboratory of Hormones and Development(Tianjin Medical University), Tianjin Key Laboratory of Metabolic Diseases, Tianjin Medical University Chu Hsien-I Memorial Hospital & Tianjin Institute of Endocrinology, Tianjin 300134, China
关键词:
亚临床甲状腺功能减退症;  糖尿病肾脏疾病;  2型糖尿病
Keywords:
Subclinical hypothyroidism;  Diabetic kidney disease;  Type 2 diabetes mellitus
DOI:
10.3760/cma.j.issn.1673-4157.2019.06.002
摘要:
目的 了解2型糖尿病(T2DM)患者中亚临床甲状腺功能减退症(SCH)与糖尿病肾脏疾病(DKD)、肾功能损伤的相关关系。方法 收集2017年9月至2018年8月在天津医科大学代谢病医院住院的656例T2DM患者,按是否合并DKD分为非DKD组(425例)和DKD组(231例)。比较2组间促甲状腺激素(TSH)水平、SCH患病率等指标差异。按TSH水平分为3组:TSH正常低值组(TSH<2.5 mIU/L,383例),TSH正常高值组(2.5 mIU/L≤TSH≤4.2 mIU/L,199例),SCH组(TSH>4.2 mIU/L,74例)。比较各组间大量白蛋白尿、DKD患病率、肾功能损伤指标等的差异,并对不同TSH水平与DKD的相关性行logistic回归分析。结果 与非DKD组相比,DKD组TSH水平、SCH患病率均升高(Z=3.670,χ2=12.978,P均<0.05)。与TSH正常低值组、TSH正常高值组相比,SCH组女性患者比例、大量白蛋白尿、DKD患病率、24 h尿蛋白定量水平均升高,估算的肾小球滤过率(eGFR)、FT4水平均降低(F=10.713～305.951,P均<0.05)。与TSH正常低值组相比,TSH正常高值组各指标差异均无统计学意义(P均>0.05)。Logistic回归分析显示,SCH与DKD独立相关(OR=2.187,95% CI: 1.244～3.847,P<0.05)。结论 T2DM患者中SCH与DKD、肾功能损伤密切相关。
Abstract:
Objective To investigate the correlation between subclinical hypothyroidism(SCH)and diabetic kidney disease(DKD), renal function injury in patients with type 2 diabetes mellitus(T2DM).Methods A total of 656 patients with T2DM in the Metabolic Disease Hospital of Tianjin Medical University were enrolled from September 2017 to August 2018and divided into non-DKD group(425 cases)and DKD group(231 cases)according to whether they merged DKD or not.The level of thyroid stimulating hormone(TSH)and the prevalence of SCH and so on were compared between two groups.All patients were divided into three groups according to their TSH levels: TSH normal low value group(TSH<2.5 mIU/L,n=383), TSH normal high value group(2.5 mIU/L≤TSH≤4.2 mIU/L, n=199)and SCH group(TSH>4.2 mIU/L,n=74). The prevalence of macroalbuminuria and DKD, injury markers of renal function and other indicators were compared among the three groups. The correlation between different levels of TSH and DKD was investigated by logistic regression analysis.Results Compared with non-DKD group, the level of thyroid stimulating hormone(TSH)and the prevalence of SCH were increased(Z=3.670,χ2=12.978, all P<0.05)in DKD group.Compared with TSH normal low value group and TSH normal high value group, the proportion of female, prevalence of macroalbuminuria, prevalence of DKD and the level of 24-hour urinary protein were increased, whereas the estimated glomerular filtration rate(eGFR)and FT4 level were decreased in SCH group(F=10.713-305.951, all P<0.05). No significant differences were found between TSH normal low value group and TSH normal high value group(all P>0.05)for all of those indicators. Logistic regression analysis showed that SCH was independently correlated with DKD(OR=2.187, 95% CI: 1.244-3.847, P<0.05).Conclusion SCH is significantly correlated with DKD and renal function injury in patients with T2DM.

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备注/Memo

备注/Memo:
通信作者:单春艳,Email:chunyanshan@hotmail.com
Corresponding author: Shan Chunyan,Email: chunyanshan@hotmail.com
基金项目:天津市科技重大专项与工程(17ZXSCSY00060); 天津市科技计划项目(17ZXHLSY00040); 天津医科大学朱宪彝纪念医院科研基金(2015DX05,2018ZDKF11); 天津市教委科研计划项目(2016YD05)
Fund program:Tianjin Major Science and Technology Projects(17ZXSCSY00060); Science and Technoogy Project in Tianjin(17ZXHLSY00040); Scientific Research Funding of Tianjin Medical University Chu Hsien-Ⅰ Memorial Hospital(2015DX05, 2018ZDKF11); The Science & Technology Development Fund of Tianjin Education Commission for Higher Education(2016YD05)
更新日期/Last Update: 2019-11-20