[1]张晓蕾 敖娜 都健.维生素D以肠道菌群为靶点治疗非酒精性脂肪性肝病的 研究进展[J].国际内分泌代谢杂志,2019,39(05):311-314.[doi:10.3760/cma.j.issn.1673-4157.2019.05.006]
 Zhang Xiaolei,Ao Na,Du Jian.Advances in the treatment of non-alcoholic fatty liver disease with vitamin D targeting intestinal flora[J].International Journal of Endocrinology and Metabolism,2019,39(05):311-314.[doi:10.3760/cma.j.issn.1673-4157.2019.05.006]
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维生素D以肠道菌群为靶点治疗非酒精性脂肪性肝病的 研究进展()
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《国际内分泌代谢杂志》[ISSN:1673-4157/CN:12-1383/R]

卷:
39
期数:
2019年05期
页码:
311-314
栏目:
综述
出版日期:
2019-09-20

文章信息/Info

Title:
Advances in the treatment of non-alcoholic fatty liver disease with vitamin D targeting intestinal flora
作者:
张晓蕾 敖娜 都健
中国医科大学附属第四医院内分泌代谢内科 沈阳,110032
Author(s):
Zhang Xiaolei Ao Na Du Jian
Department of Endocrinology and Metabolism, The Fourth Affiliated Hospital of China Medical University, Shenyang 110032, China
关键词:
维生素D 肠道菌群 非酒精性脂肪性肝病
Keywords:
Vitamin D Intestinal flora Non-alcoholic fatty liver disease
DOI:
10.3760/cma.j.issn.1673-4157.2019.05.006
摘要:
非酒精性脂肪性肝病(NAFLD)的发病率逐年增加,相关研究已经证实,肠道菌群与NAFLD的发生、发展密切相关,合理利用肠道菌群的调节作用可以增强肠道黏膜屏障作用,减少肝脏炎性反应,促进能量物质代谢,从而对NAFLD有一定的积极治疗作用。维生素D除了调节钙、磷代谢外,近年来其骨骼外的作用越来越得到重视,而且已有证据表明,维生素D与肠道菌群存在紧密联系。以下就维生素D对肠道菌群的影响、肠道菌群对NAFLD的干预作用以及维生素D如何靶向肠道菌群,进而影响NAFLD结局的可能机制进行阐述。
Abstract:
The incidence of non-alcoholic fatty liver disease(NAFLD)increases year by year, and relevant studies have confirmed that intestinal flora is closely related to the occurrence and development of NAFLD. Proper use of the regulatory role of intestinal flora can enhance the role of intestinal mucosal barrier, reduce the inflammatory reaction in the liver and enhance the metabolism of energy substances, thus playing a positive role in the treatment of NAFLD. In addition to regulating the metabolism of calcium and phosphorus, vitamin D has received more and more attention in recent years for its role outside the bone, and there has been evidence that vitamin D is directly related to the intestinal flora. The effects of vitamin D on intestinal flora, the intervention effect of intestinal flora on NAFLD, and how vitamin D targets intestinal flora and thus affects the outcome of NAFLD are described below.

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备注/Memo

备注/Memo:
通信作者:都健,Email:dujianbox@126.com
Corresponding author: Du Jian, Email:dujianbox@126.com
基金项目:北京医卫健康公益基因会项目(hxkt60); 辽宁省高等学校基本科研项目(LQNK201715)
Fund program:Beijing Medical and Health Public Welfare Association Project(hxkt60); Basic Scientific Research Project of Institutions of Higher Learning in Liaoning Province(LQNK201715)
更新日期/Last Update: 2019-09-20