[1]沈祯敏 邵莉.整合素相关蛋白及其配体在糖脂代谢中的作用[J].国际内分泌代谢杂志,2018,38(05):336-338346.[doi:10.3760/cma.j.issn.1673-4157.2018.05.013]
 Shen Zhenmin,Shao Li.Roles of integrin associated protein and its ligands in glucose and lipid metabolism[J].International Journal of Endocrinology and Metabolism,2018,38(05):336-338346.[doi:10.3760/cma.j.issn.1673-4157.2018.05.013]
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整合素相关蛋白及其配体在糖脂代谢中的作用()
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《国际内分泌代谢杂志》[ISSN:1673-4157/CN:12-1383/R]

卷:
38
期数:
2018年05期
页码:
336-338346
栏目:
基础研究
出版日期:
2018-09-20

文章信息/Info

Title:
Roles of integrin associated protein and its ligands in glucose and lipid metabolism
作者:
沈祯敏 邵莉
作者单位:200120 上海,同济大学附属上海市东方医院特诊部
Author(s):
Shen Zhenmin Shao Li
The VIP Department, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai 200120, China
关键词:
整合素相关蛋白 信号调节蛋白-α 血小板反应蛋白-1 糖脂代谢
Keywords:
Integrin associated protein Signal regulatory protein-α Thrombospondin-1 Glucose and lipid metabolism
DOI:
10.3760/cma.j.issn.1673-4157.2018.05.013
摘要:
整合素相关蛋白(CD47)是在体内广泛分布的跨膜蛋白,其主要配体包括信号调节蛋白-α(SIRP-α)与血小板反应蛋白(TSP)-1。近年来,CD47与其主要配体在糖、脂代谢方面的研究取得了多方面的突破,尤其是与饮食诱导的肥胖、1型糖尿病的发生以及胰岛素功能的调节都有一定的相关性。探索CD47及其配体在糖、脂代谢中的作用机制,将为治疗糖尿病及肥胖提供新思路和潜在靶点。
Abstract:
Integrin associated protein(CD47)is a widely distributed trans-membrane protein including two major ligands, signal regulatory protein-α(SIRP-α)and thrombospondin-1(TSP-1). In recent years, CD47 and the major ligands have made great breakthroughs in the study of glucose and lipid metabolism. Especially, the protein and its ligands have a certain degree of correlation with diet-induced obesity, the occurrence of type 1 diabetes, and regulation of insulin function. Investigation of the mechanisms of CD47 and its ligands in glucose and lipid metabolism will further provide potential targets and new ideas for the treatment of diabetes and obesity.

参考文献/References:


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备注/Memo

备注/Memo:
基金项目:上海市自然科学基金(18ZR1430900); 同济大学中央高校基本科研业务费专项资金(22120170136)
Fund program:Natural Science Foundation of Shanghai of China(18ZR1430900); Fundamental Research Funds for the Central Universities(22120170136)
作者单位:200120 上海,同济大学附属上海市东方医院特诊部
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更新日期/Last Update: 2018-09-30