[1]叶燕珍 杜建玲.成纤维细胞生长因子在糖尿病中的作用[J].国际内分泌代谢杂志,2018,38(03):200-203212.[doi:10.3760/cma.j.issn.1673-4157.2018.03.014]
 Ye Yanzhen,Du Jianling.Effects of fibroblast growth factor in diabetes mellitus[J].International Journal of Endocrinology and Metabolism,2018,38(03):200-203212.[doi:10.3760/cma.j.issn.1673-4157.2018.03.014]
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成纤维细胞生长因子在糖尿病中的作用()
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《国际内分泌代谢杂志》[ISSN:1673-4157/CN:12-1383/R]

卷:
38
期数:
2018年03期
页码:
200-203212
栏目:
基础研究
出版日期:
2018-05-20

文章信息/Info

Title:
Effects of fibroblast growth factor in diabetes mellitus
作者:
叶燕珍 杜建玲
116011 大连医科大学附属第一医院内分泌科(叶燕珍、杜建玲); 116200 大连医科大学附属第三医院内分泌科(叶燕珍)
Author(s):
Ye Yanzhen Du Jianling
Department of Endocrinology, The First Affiliated Hospital of Dalian Medical University, Dalian 116011, China; Department of Endocrinology, The Third Affiliated Hospital of Dalian Medical University, Dalian 116200, China
关键词:
成纤维细胞生长因子 糖代谢 糖尿病
Keywords:
Fibroblast growth factor Glucose metabolism Diabetes mellitus
DOI:
10.3760/cma.j.issn.1673-4157.2018.03.014
摘要:
研究显示,成纤维细胞生长因子(FGF)1、FGF19、FGF21及FGF23参与糖代谢调节。FGF1主要通过抑制下丘脑-垂体-肾上腺轴、减少肝脏乙酰辅酶A合成、增强胰岛素敏感性以及中枢机制发挥降糖作用。FGF19具有增加糖原和蛋白质合成,减少糖异生的作用。FGF21的降糖机制包括促进胰岛素分泌、增加胰岛素敏感性、提高糖代谢及抑制胰高血糖素的分泌。FGF23与糖代谢有关,但机制尚不明确。其中FGF1降糖效果最显著,FGF家族可能成为糖尿病治疗的新靶点。
Abstract:
Many studies have shown that fibroblast growth factor(FGF)1, FGF19, FGF21 and FGF23 were involved in glucose metabolism. FGF1 could lower blood glucose by suppression of hypothalamic pituitary adrenal axis, reducing the synthesis of acetyl coenzyme A, enhancing insulin sensitivity, and the central effect. FGF19 had the effect of increasing glycogen and protein synthesis and reducing gluconeogenesis. The antidiabetic mechanisms of FGF21 included promoting the secretion of insulin, increasing the sensitivity of insulin, enhancing glucose metabolism and inhibiting glucagon secretion. FGF23 was related to glucose metabolism, but the mechanism is unclear. Among them, the effects FGF1 are more significant. FGF family may become a new target for the treatment of diabetes mellitus.

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通信作者:杜建玲,Email: dujianling63@163.com
更新日期/Last Update: 2018-03-30