[1]王魏 邵加庆.中性粒细胞胞外捕网在痛风性关节炎中的作用机制[J].国际内分泌代谢杂志,2018,38(02):131-134.[doi:10.3760/cma.j.issn.1673-4157.2018.02.016]
　Wang Wei,Shao Jiaqing.Role of neutrophil extracellular traps in acute gouty arthritis[J].International Journal of Endocrinology and Metabolism,2018,38(02):131-134.[doi:10.3760/cma.j.issn.1673-4157.2018.02.016]
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中性粒细胞胞外捕网在痛风性关节炎中的作用机制()
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《国际内分泌代谢杂志》[ISSN:1673-4157/CN:12-1383/R]

卷:
38
期数:
2018年02期
页码:
131-134
栏目:
基础研究
出版日期:
2018-03-20

文章信息/Info

Title:
Role of neutrophil extracellular traps in acute gouty arthritis
作者:
王魏 邵加庆
210002 南京大学医学院(解放军南京总医院)内分泌科
Author(s):
Wang Wei;  Shao Jiaqing
Department of Endocrinology, Clinical Medicine, Nanjing University/Nanjing General Hospital of PLA, Nanjing 210002, China
关键词:
中性粒细胞胞外捕网;  痛风性关节炎;  炎症
Keywords:
Neutrophil extracellular trap;  Gout;  Inflammation
DOI:
10.3760/cma.j.issn.1673-4157.2018.02.016
摘要:
急性痛风性关节炎是痛风最常见的首发症状,早期常可于短时间内自行缓解,随着病程进展,发作频率逐渐增加,持续时间逐渐延长,直至无法自行缓解,并伴发痛风石的形成,其具体机制尚未阐明。近年有研究发现,中性粒细胞胞外捕网可以激活免疫系统,同时聚集中性粒细胞胞外捕网可能通过降低细胞因子和趋化因子水平,缓解痛风急性期炎性反应,并且可与尿酸盐结晶紧密结合,参与痛风石的形成。
Abstract:
Acute gouty arthritis is the first symptom of gout,which resolves spontaneously within a few days. With the development of gout, arthritis occurs more frequently and harder to resolve, meanwhile the urate crystals deposite into tophi, however the reason is still not clear. Recently evidences suggest that neutrophil extracellular traps can activate the body immune system, and aggregated neutrophil extracellular traps can promote the resolution of neutrophilic inflammation by degrading cytokines and chemokines. What's more, aggregated neutrophil extracellular traps also contribute to the formation of tophi by combining with the monosodiumurate crystals.

参考文献/References:


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备注/Memo

备注/Memo:
基金项目:国家自然科学基金(81471018)
通信作者:邵加庆,Email:shaojiaq@hotmail.com
更新日期/Last Update: 1900-01-01