[1]杨曦,刘玉洁,马慧娟.生长分化因子15与肥胖及糖尿病[J].国际内分泌代谢杂志,2016,36(06):388-390.[doi:10.3760/cma.j.issn.1673-4157.2016.06.07]
 Yang Xi*,Liu Yujie,Ma Huijuan..Growth differentiation factor-15 and obesity, diabetes mellitus[J].International Journal of Endocrinology and Metabolism,2016,36(06):388-390.[doi:10.3760/cma.j.issn.1673-4157.2016.06.07]
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生长分化因子15与肥胖及糖尿病()
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《国际内分泌代谢杂志》[ISSN:1673-4157/CN:12-1383/R]

卷:
36
期数:
2016年06期
页码:
388-390
栏目:
综述
出版日期:
2016-11-20

文章信息/Info

Title:
Growth differentiation factor-15 and obesity, diabetes mellitus
作者:
杨曦刘玉洁马慧娟
050017 石家庄,河北医科大学研究生学院(杨曦,刘玉洁),内科学教研室(马慧娟); 050051 石家庄,河北省人民医院内分泌科(马慧娟)
Author(s):
Yang Xi* Liu Yujie Ma Huijuan.
*Graduate Institute of Hebei Medical University, Shijiazhuang 050017, China
关键词:
生长分化因子15 肥胖症 糖尿病
Keywords:
Growth differentiation factor-15 Obesity Diabetes mellitus
DOI:
10.3760/cma.j.issn.1673-4157.2016.06.07
摘要:
生长分化因子15(GDF15)属于转化生长因子-β(TGF-β)超家族,主要表达于巨噬细胞、脂肪细胞及内皮细胞中。作为一种新型脂肪细胞因子,GDF15具有抗炎,促进氧化代谢,抑制食欲和减轻体重的作用,从而改善肥胖、胰岛素抵抗和糖耐量。其有望成为治疗肥胖和2型糖尿病的外周新靶点。
Abstract:
Growth differentiation factor-15 is a divergent member of the transforming growth factor-beta(TGF-β)superfamily, which mainly expressed in the macrophage cells, adipocytes and endothelial cells. As a novel adipokine, GDF15 shows many effects in anti-inflammatory, promoting oxidative metabolism, inhibiting appetite and weight loss, which can improve obesity, insulin resistance and glucose tolerance. GDF15 represents a new target for the treatment of obesity and type 2 diabetes.

参考文献/References:

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更新日期/Last Update: 2016-12-20