[1]高胜利,郭菲菲,徐珞,等.Nesfatin-1与肥胖的关系[J].国际内分泌代谢杂志,2016,36(06):384-387.[doi:10.3760/cma.j.issn.1673-4157.2016.06.06]
 Gao Shengli,Guo Feifei,Xu Luo,et al.Relationship between nesfatin-1 and obesity[J].International Journal of Endocrinology and Metabolism,2016,36(06):384-387.[doi:10.3760/cma.j.issn.1673-4157.2016.06.06]
点击复制

Nesfatin-1与肥胖的关系()
分享到:

《国际内分泌代谢杂志》[ISSN:1673-4157/CN:12-1383/R]

卷:
36
期数:
2016年06期
页码:
384-387
栏目:
综述
出版日期:
2016-11-20

文章信息/Info

Title:
Relationship between nesfatin-1 and obesity
作者:
高胜利郭菲菲徐珞孙向荣
266021 青岛大学基础医学院病理生理学教研室
Author(s):
Gao Shengli Guo Feifei Xu Luo Sun Xiangrong.
Department of Pathophysiology, School of Basic Medicine, Qingdao University, Qingdao 266021, China
关键词:
Nesfatin-1 Nucleobindin 2 摄食抑制 神经肽 肥胖症
Keywords:
Nesfatin-1 Nucleobindin 2 Feeding inhibition Neuropeptide Obesity
DOI:
10.3760/cma.j.issn.1673-4157.2016.06.06
摘要:
Nesfatin-1是一种新发现的摄食抑制性脑肠肽,在中枢神经系统和多个外周组织中均有表达。Nesfatin-1基因多态性或蛋白表达异常均可能引发摄食增多和肥胖。Nesfatin-1可直接作用于摄食相关神经元,减轻肥胖程度; 也可通过影响催产素、神经肽Y等神经肽的表达和功能,间接发挥降低体重的作用。
Abstract:
Nesfatin-1 is a novel anorexigenic brain-gut peptide and expressed in central nerve system and multiple peripheral tissues. Polymorphism and abnormal protein expression of nesfatin-1 might lead to hyperphagia and obesity. Nesfatin-1 not only directly abates obesity by influencing feeding-related neurons, but also indirectly decreases body weight by affecting the expressions and functions of many neuropeptides, such as oxytocin, neuropeptide Y, and so on.

参考文献/References:

[1] Oh-I S, Shimizu H, Satoh T,et al. Identification of nesfatin-1 as a satiety molecule in the hypothalamus[J].Nature, 2006,443(7112):709-712. DOI:10.1038/nature05162.
[2] Shimizu H, Oh-I S, Hashimoto K,et al. Peripheral administration of nesfatin-1 reduces food intake in mice: the leptin-independent mechanism[J].Endocrinology, 2009,150(2):662-671. DOI: 10.1210/en.2008-0598.
[3] Sáinz N, Barrenetxe J, Moreno-Aliaga MJ,et al. Leptin resistance and diet-induced obesity: central and peripheral actions of leptin[J].Metabolism, 2015,64(1):35-46. DOI: 10.1016/j.metabol.2014.10.015.
[4] Mohan H, Unniappan S. Phylogenetic aspects of nucleobindin-2/nesfatin-1[J].Curr Pharm Des, 2013,19(39):6929-6934.
[5] Ishida E, Hashimoto K, Shimizu H,et al. Nesfatin-1 induces the phosphorylation levels of cAMP response element-binding protein for intracellular signaling in a neural cell line[J].PLoS One,2012,7(12):e50918. DOI: 10.1371/journal.pone.0050918.
[6] Brailoiu GC, Dun SL, Brailoiu E,et al. Nesfatin-1: distribution and interaction with a G protein-coupled receptor in the rat brain[J].Endocrinology, 2007,148(10):5088-5094.DOI:10.1210/en.2007-0701.
[7] Xia ZF, Fritze DM, Li JY,et al. Nesfatin-1 inhibits gastric acid secretion via a central vagal mechanism in rats[J].Am J Physiol Gastrointest Liver Physiol, 2012,303(5):G570-G577. DOI: 10.1152/ajpgi.00178.2012.
[8] Gonzalez R, Kerbel B, Chun A,et al. Molecular, cellular and physiological evidences for the anorexigenic actions of nesfatin-1 in goldfish[J].PLoS One, 2010,5(12):e15201.DOI: 10.1371/journal.pone.0015201.
[9] Feijóo-Bandín S, Rodríguez-Penas D, García-Rúa V,et al. Nesfatin-1 in human and murine cardiomyocytes: synthesis, secretion, and mobilization of GLUT-4[J].Endocrinology, 2013,154(12):4757-4767.DOI: 10.1210/en.2013-1497.
[10] Stengel A, Goebel M, Yakubov I,et al. Identification and characterization of nesfatin-1 immunoreactivity in endocrine cell types of the rat gastric oxyntic mucosa[J].Endocrinology, 2009,150(1):232-238. DOI: 10.1210/en.2008-0747.
[11] Stengel A, Hofmann T, Goebel-Stengel M,et al. Ghrelin and NUCB2/nesfatin-1 are expressed in the same gastric cell and differentially correlated with body mass index in obese subjects[J].Histochem Cell Biol, 2013,139(6):909-918. DOI: 10.1007/s00418-013-1087-8.
[12] Foo KS, Brauner H, Ostenson CG,et al. Nucleobindin-2/nesfatin in the endocrine pancreas: distribution and relationship to glycaemic state[J].J Endocrinol, 2010,204(3):255-263. DOI: 10.1677/JOE-09-0254.
[13] Zegers D, Beckers S, Mertens IL,et al. Association between polymorphisms of the nesfatin gene, NUCB2, and obesity in men[J].Mol Genet Metab, 2011,103(3):282-286.DOI:10.1016/j.ymgme.2011.03.007.
[14] Zegers D, Beckers S, de Freitas F,et al. Identification of mutations in the NUCB2/nesfatin gene in children with severe obesity[J].Mol Genet Metab, 2012,107(4):729-734.DOI:10.1016/j.ymgme.2012.10.014.
[15] Ramanjaneya M, Chen J, Brown JE,et al. Identification of nesfatin-1 in human and murine adipose tissue: a novel depot-specific adipokine with increased levels in obesity[J].Endocrinology, 2010,151(7):3169-3180. DOI: 10.1210/en.2009-1358.
[16] Mohan H, Ramesh N, Mortazavi S,et al. Nutrients differentially regulate nucleobindin-2/nesfatin-1 in vitro in cultured stomach ghrelinoma(MGN3-1)cells and in vivo in male mice[J].PLoS One, 2014,9(12):e115102. DOI: 10.1371/journal.pone.0115102.
[17] Lee WJ, Chen CY, Ser KH,et al. Differential influences of gastric bypass and sleeve gastrectomy on plasma nesfatin-1 and obestatin levels in patients with type 2 diabetes mellitus[J].Curr Pharm Des, 2013,19(32):5830-5835.
[18] An|k A, ?atl|G, Abac|A,et al. Fasting and postprandial levels of a novel anorexigenic peptide nesfatin in childhood obesity[J].J Pediatr Endocrinol Metab, 2014,27(7-8):623-628. DOI: 10.1515/jpem-2013-0475.
[19] Goebel M, Stengel A, Wang L,et al. Central nesfatin-1 reduces the nocturnal food intake in mice by reducing meal size and increasing inter-meal intervals[J].Peptides, 2011,32(1):36-43. DOI: 10.1016/j.peptides.2010.09.027.
[20] Dong J, Guan HZ, Jiang ZY,et al. Nesfatin-1 influences the excitability of glucosensing neurons in the dorsal vagal complex and inhibits food intake[J].PLoS One, 2014,9(6):e98967. DOI: 10.1371/journal.pone.0098967.
[21] K?ncz l K, Pintér O, Ferenczi S,et al. Nesfatin-1 exerts long-term effect on food intake and body temperature[J].Int J Obes(Lond), 2012,36(12):1514-1521. DOI: 10.1038/ijo.2012.2.
[22] Atsuchi K, Asakawa A, Ushikai M,et al. Centrally administered nesfatin-1 inhibits feeding behaviour and gastroduodenal motility in mice[J].Neuroreport, 2010,21(15):1008-1011. DOI: 10.1097/WNR.0b013e32833f7b96.
[23] Stengel A, Goebel-Stengel M, Wang L,et al. Nesfatin-1(30-59)but not the N- and C-terminal fragments, nesfatin-1(1-29)and nesfatin-1(60-82)injected intracerebroventricularly decreases dark phase food intake by increasing inter-meal intervals in mice[J].Peptides, 2012,35(2):143-148. DOI: 10.1016/j.peptides.2012.03.015.
[24] Darambazar G, Nakata M, Okada T,et al. Paraventricular NUCB2/nesfatin-1 is directly targeted by leptin and mediates its anorexigenic effect[J].Biochem Biophys Res Commun, 2015,456(4):913-918. DOI: 10.1016/j.bbrc.2014.12.065.
[25] Stengel A. Nesfatin-1--More than a food intake regulatory peptide[J].Peptides, 2015,72:175-183. DOI: 10.1016/j.peptides.2015.06.002.
[26] Stengel A, Goebel M, Wang L,et al. Central nesfatin-1 reduces dark-phase food intake and gastric emptying in rats: differential role of corticotropin-releasing factor 2 receptor[J].Endocrinology, 2009,150(11):4911-4919. DOI: 10.1210/en.2009-0578.
[27] Gonzalez R, Perry RL, Gao X,et al. Nutrient responsive nesfatin-1 regulates energy balance and induces glucose-stimulated insulin secretion in rats[J].Endocrinology, 2011,152(10):3628-3637. DOI: 10.1210/en.2010-1471.
[28] Iwasaki Y, Nakabayashi H, Kakei M,et al. Nesfatin-1 evokes Ca2+ signaling in isolated vagal afferent neurons via Ca2+ influx through N-type channels[J].Biochem Biophys Res Commun, 2009,390(3):958-962. DOI: 10.1016/j.bbrc.2009.10.085.

备注/Memo

备注/Memo:
基金项目:国家自然科学基金青年项目(81500414); 山东省优秀中青年科学家科研奖励基金(BS2014YY009)
更新日期/Last Update: 2016-12-20