[1]王涛,张洁,祁范范,等.不同糖耐量人群血清25(OH)D3水平 及与胰岛β细胞功能的关系[J].国际内分泌代谢杂志,2016,36(04):226-229.[doi:10.3760/cma.j.issn.1673-4157.2016.04.04]
　Wang Tao*,Zhang Jie,Qi Fanfan,et al.Relationship between serum 25(OH)D3 level and islet β cell function in individuals with different glucose tolerance[J].International Journal of Endocrinology and Metabolism,2016,36(04):226-229.[doi:10.3760/cma.j.issn.1673-4157.2016.04.04]
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不同糖耐量人群血清25(OH)D3水平 及与胰岛β细胞功能的关系()
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《国际内分泌代谢杂志》[ISSN:1673-4157/CN:12-1383/R]

卷:
36
期数:
2016年04期
页码:
226-229
栏目:
论著
出版日期:
2016-07-20

文章信息/Info

Title:
Relationship between serum 25(OH)D3 level and islet β cell function in individuals with different glucose tolerance
作者:
王涛; 张洁; 祁范范; 刘岩; 庞建华; 周慧敏; 周亚茹
050051 石家庄,河北医科大学第三医院心内科(王涛),内分泌科(张洁,祁范范, 刘岩, 庞建华, 周亚茹); 050051 石家庄,河北医科大学第一医院内分泌科(周慧敏)
Author(s):
Wang Tao*;  Zhang Jie;  Qi Fanfan;  Liu Yan;  Pang Jianhua;  Zhou Huimin;  Zhou Yaru
*Department of Cardiology, The Third Hospital of Hebei Medical University, Shijiazhuang 050051, China
关键词:
25(OH)D3;  维生素D;  2型糖尿病;  胰岛素分泌
Keywords:
25(OH)D3;  Vitamin D;  Type 2 diabetes mellitus;  Insulin secretion
DOI:
10.3760/cma.j.issn.1673-4157.2016.04.04
摘要:
目的 比较不同糖耐量人群血清25(OH)D3水平,分析其与胰岛β细胞功能的关系。方法 共纳入131例受试者,包括新诊断2型糖尿病患者(T2DM组)50例,糖调节受损者(IGR组)45名和糖耐量正常者(NGT组)36名。收集临床资料并检测相关生化指标,采用酶联免疫吸附法测定空腹血清25(OH)D3水平。结果 NGT组、IGR组和T2DM组血清25(OH)D3水平依次下降(F=25.984, P<0.05)。血清25(OH)D3与体重指数、腰围、臀围、腰臀比、空腹血糖、口服葡萄糖耐量试验2 h血糖(2 hPG)呈负相关(r=-0.600～-0.175,P均<0.05),与空腹胰岛素(FINS)、胰岛素曲线下面积、稳态模型评估-胰岛β细胞功能指数、早相胰岛素分泌指数(ΔINS30/ΔG30)呈直线正相关(r=0.296～0.693,P均<0.05)。多元逐步回归分析显示,2 hPG、ΔINS30/ΔG30是血清25(OH)D3水平的独立相关因素(β=0.204, -0.178,P均<0.05)。结论 IGR者与T2DM患者25(OH)D3水平降低。血清25(OH)D3与胰岛素分泌功能呈正相关,与肥胖、血糖水平呈负相关。
Abstract:
Objective To compare the level of serum 25(OH)D3 in individuals with different glucose tolerance and explore the relationship between serum 25(OH)D3 and islet β cell function. Methods A total of 131 subjects including patients with newly diagnosed type 2 diabetes(T2DM group, n=50), individuals with impaired glucose regulation(IGR group, n=45)and individuals with normal glucose tolerance(NGT group, n=36)were included in this study. Clinical data and biochemical parameters were collected. Serum 25(OH)D3 was measured by enzyme linked immunosorbent assay. Results Compared with NGT group, the levels of serum 25(OH)D3 were decreased in IGR group and T2DM group. The level of serum 25(OH)D3 was negatively correlated with body mass index, waist circumference, hip circumference, waist-to-hip ratio, fasting plasma glucose and oral glucose tolerance test 2 hour plasma glucose(2 hPG)(r=-0.600 to -0.175,all P<0.05), and was positively correlated with fasting insulin, insulin area under curve, homeostasis model assessment β-cell function and early phase insulin secretion(ΔINS30/G30)(r=0.296 to 0.693, all P<0.05). Multiple stepwise regression analysis showed that 2 hPG, ΔINS30/ΔG30 were independent related factors of the level of serum 25(OH)D3(β=0.204, -0.178, all P<0.05). Conclusions The level of serum 25(OH)D3 is decreased in patients with IGR and T2DM. Serum 25(OH)D3 is positively correlated to insulin secretion, and negatively correlated to obesity and blood glucose.

参考文献/References:

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备注/Memo

备注/Memo:
基金项目:河北省医学适用技术跟踪项目(GL201340) 通信作者:周亚茹,Email:zhouyaru_hc@163.com
更新日期/Last Update: 2016-09-20