[1]邵滢,王秋月.Mir-217/Sirt1通路与糖尿病肾病[J].国际内分泌代谢杂志,2015,(02):124-126.[doi:10.3760/cma.j.issn.1673-4157.2015.02.014]
 Shao Ying,Wang Qiuyue..Mir-217 / Sirt1 pathway and diabetic nephropathy[J].International Journal of Endocrinology and Metabolism,2015,(02):124-126.[doi:10.3760/cma.j.issn.1673-4157.2015.02.014]
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Mir-217/Sirt1通路与糖尿病肾病()
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《国际内分泌代谢杂志》[ISSN:1673-4157/CN:12-1383/R]

卷:
期数:
2015年02
页码:
124-126
栏目:
综述
出版日期:
2015-03-20

文章信息/Info

Title:
Mir-217 / Sirt1 pathway and diabetic nephropathy
作者:
邵滢王秋月
100011 沈阳,中国医科大学附属第一医院内分泌科   
Author(s):
Shao YingWang Qiuyue.
Department of Endocrinology,The First Affiliated Hospital of China Medical University,Shenyang 110001,China Corresponding author:Wang Qiuyue,Email:wqycmu@163.com
关键词:
miRNAsMir-217Sirt1肾脏纤维化糖尿病肾病
Keywords:
MiRNAsMir-217Sirt1Renal fibrosisDiabetic nephropathy
DOI:
10.3760/cma.j.issn.1673-4157.2015.02.014
摘要:
Mir-217是miRNAs家族的重要成员,在高糖培养的肾小球系膜细胞中表达量升高。Sirt1是一个NAD+调节的脱乙酰酶,既往在衰老性疾病中研究较多,近期发现其在糖尿病肾病中起到抗炎、抗氧化、抗纤维化等保护作用。研究指出,在多种病理条件下mir-217通过直接作用于Sirt1 mRNA的3'非翻译区,显著抑制Sirt1蛋白表达,因此mir-217/Sirt1通路可能在糖尿病肾病的发生、发展中起关键作用。
Abstract:
Mir-217 is an important member of the miRNAs family overexpressed in high glucose cultured glomerular mesangial cells. Sirt1 is an NAD (+) -dependent deacetylase,which has obtained great focus on the research of aging. Recent researches reported that Sirt1 has protective functions in diabetic nephropathy such as anti-inflammation,anti-oxidance and anti-fibrosis. In a variety of pathological conditions, mir-217 directly acts on the 3 ' translation section of Sirt1 mRNA,and inhibits expression of Sirt1 protein. Thus, mir-217/Sirt1 pathway may play a key role in the occurrence and development of diabetic nephropathy.

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备注/Memo

备注/Memo:
基金项目:辽宁省科学技术计划项目(2011225017);辽宁省百千万人才工程资助项目(2011921037) 通信作者:王秋月,Email:wqycmu@163.com
更新日期/Last Update: 2015-03-20