[1]王育榕,孙嘉.脂肪因子对骨代谢影响的研究进展[J].国际内分泌代谢杂志,2014,(02):95-98,102.[doi:10.3760/cma.j.issn.1673-4157.2014.02.007]
 Wang Yurong,Sun Jia..Influence of adipokines on bone metabolism[J].International Journal of Endocrinology and Metabolism,2014,(02):95-98,102.[doi:10.3760/cma.j.issn.1673-4157.2014.02.007]
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脂肪因子对骨代谢影响的研究进展()
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《国际内分泌代谢杂志》[ISSN:1673-4157/CN:12-1383/R]

卷:
期数:
2014年02期
页码:
95-98,102
栏目:
骨代谢疾病专栏
出版日期:
2014-04-30

文章信息/Info

Title:
Influence of adipokines on bone metabolism
作者:
王育榕孙嘉
510282 广州,南方医科大学珠江医院(第二临床医学院)   
Author(s):
Wang YurongSun Jia.
Zhujiang Hospital(Second College of Clinical Medicine),Southern Medical University,Guangzhou 510282,China Corresponding author:Sun Jia,Email:nfmsj@126.com
关键词:
脂肪因子骨代谢
Keywords:
AdipokinesBone metabolism
DOI:
10.3760/cma.j.issn.1673-4157.2014.02.007
摘要:
脂肪因子是主要由脂肪组织分泌,对骨代谢具有重要调节作用的蛋白质。脂肪因子种类繁多,包括脂联素、瘦素、趋化素等。不同脂肪因子对骨代谢的影响不尽相同。脂联素、网膜素-1、丝氨酸蛋白酶抑制剂、内脂素可正向调节骨代谢。趋化素、抵抗素对骨代谢具有负向调节作用。瘦素对骨代谢的影响则表现为直接的正向调节作用和间接的负向调节作用。脂肪因子对骨代谢的调节作用可能为骨质疏松的治疗提供新方向。
Abstract:
Adipokines are proteins mainly secreted by adipose tissue. Adipokines play an important role in the regulation of bone metabolism.There are many kinds of adipokines,such as adiponectin,leptin and chemirin. Their effects on bone remodeling vary in different adipokines.Adiponectin,omentin-1,vaspin,visfatin act positively on bone metabolism.Chemirin and resistin act negatively on bone metabolism.Leptin acts both positively and negatively on bone metabolism in direct and indirect ways.The regulation of adipokines on bone remodeling may provide a new direction for the treatment of osteoporosis.

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备注/Memo

备注/Memo:
基金项目:国家自然科学基金资助项目(81300689) 通信作者:孙嘉,Email:nfmsj@126.com
更新日期/Last Update: 2014-03-20