[1]孙如琼,林少达.宫内发育迟缓与糖脂代谢异常[J].国际内分泌代谢杂志,2014,(01):25-28.[doi:10.3760/cma.j.issn.1673-4157.2014.01.007]
 Sun Ruqiong,Lin Shaoda.Intrauterine growth retardation and disorder of glucolipid metabolism[J].International Journal of Endocrinology and Metabolism,2014,(01):25-28.[doi:10.3760/cma.j.issn.1673-4157.2014.01.007]
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宫内发育迟缓与糖脂代谢异常()
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《国际内分泌代谢杂志》[ISSN:1673-4157/CN:12-1383/R]

卷:
期数:
2014年01期
页码:
25-28
栏目:
综述
出版日期:
2014-02-28

文章信息/Info

Title:
Intrauterine growth retardation and disorder of glucolipid metabolism
作者:
孙如琼林少达
515041 汕头大学医学院第一附属医院内分泌科   
Author(s):
Sun RuqiongLin Shaoda.
Department of Endocrinology,The First Affiliated Hospital of Shantou University Medical College,Shantou 515041,China Corresponding author: Lin Shaoda,Email:linshaoda@126.com
关键词:
宫内发育迟缓糖脂代谢肥胖
Keywords:
Intrauterine growth retardationGlucolipid metabolismObesity
DOI:
10.3760/cma.j.issn.1673-4157.2014.01.007
摘要:
流行病学研究显示,宫内发育迟缓(IUGR)是糖耐量异常、肥胖、2型糖尿病等代谢性疾病的危险因素。下丘脑神经肽Y表达上调、瘦素中枢受体分布异常、ghrelin作用异常及下丘脑-垂体-肾上腺轴功能紊乱;外周内分泌激素如瘦素、脂联素、胰岛素样生长因子-1的水平异常,胰岛素信号通路的改变以及代谢相关基因、酶的改变均为重要的影响因素。对糖、脂代谢异常机制的探讨可为防治IUGR个体出现代谢性疾病提供新的方向。
Abstract:
Epidemiologic studies show intrauterine growth retardation(IUGR) is a risk factor of metabolic diseases including impaired glucose tolerance,obesity and type 2 diabetes.Up-regulation of hypothalamic neturopetide Y(NPY),changed distribution of leptin receptor,abnormal effect of ghrelin, dysfunction of hypothalamic-pituitary-adrenal axis,improperly level of peripheric hormones such as leptin, adiponectin and insulin-like growth factor-1,changed insulin signal pathway,abnormal levels of metabolism related genes and enzymes are important factors.Clarificating the mechanisms of disorder of glucolipid metabolism will supply a new direction for the prevention and treatment of metabolic diseases in individuals with IUGR.

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备注/Memo

备注/Memo:
基金项目:国家自然科学基金资助项目(81170711);广东省自然科学基金(S20110100051030) 通信作者:林少达,Email:linshaoda@126.com
更新日期/Last Update: 2014-01-20