[1]黄江燕,董力,邹贵勉,等.广西城市社区居民高尿酸血症流行病学调查[J].国际内分泌代谢杂志,2014,(01):5-9.[doi:10.3760/cma.j.issn.1673-4157.2014.01.002]
　Huang Jiangyan*,Dong Li,Zou Guimian,et al.Epidemiological survey of hyperuricemia in the Guangxi urban community residents[J].International Journal of Endocrinology and Metabolism,2014,(01):5-9.[doi:10.3760/cma.j.issn.1673-4157.2014.01.002]
点击复制

广西城市社区居民高尿酸血症流行病学调查()
分享到：

《国际内分泌代谢杂志》[ISSN:1673-4157/CN:12-1383/R]

卷:
期数:
2014年01期
页码:
5-9
栏目:
论著
出版日期:
2014-02-28

文章信息/Info

Title:
Epidemiological survey of hyperuricemia in the Guangxi urban community residents
作者:
黄江燕; 董力; 邹贵勉; 车文体; 眭维国; 陈洁晶; 邹和群; 向月应
541002　桂林,解放军第181医院全军器官移植与透析治疗中心,广西代谢性疾病研究重点实验室（黄江燕,董力,邹贵勉,车文体,眭维国,陈洁晶,向月应）；510630　广州,南方医科大学第三附属医院肾内科（邹和群） 　　
Author(s):
Huang Jiangyan*; Dong Li; Zou Guimian; Che Wenti; Sui Weiguo; Chen Jiejing; Zou Hequn; Xiang Yueying．
*Center of Organ Transplantation and Dialysis of PLA,Guangxi Key Laboratory of Metabolic Disease Research,No. 181 Hospital of PLA,Guilin 541002,China Corresponding author：Zou Guimian,Email：zougm2004@126.com
关键词:
高尿酸血症; 社区筛查; 患病率; 危险因素
Keywords:
Hyperuricemia; Community-base screening; Incidence; Risk factors
DOI:
10.3760/cma.j.issn.1673-4157.2014.01.002
摘要:
目的　研究城市社区居民高尿酸血症（HUA）的患病率及相关危险因素,提出有效防治措施。方法　对6 273名18～75岁的桂林市象山区城市社区居民进行横断面调查,收集空腹静脉血样本及尿液检测血糖、肾功能、尿常规及尿微量白蛋白等,同时进行问卷调查和体格检查。结果　在城市社区居民中HUA的总患病率为23.5%,男性为28.4%,显著高于女性的19.7%（χ2=1 332.576,P＜0.01）。校正血肌酐后,血尿酸水平与体重（或体重指数）、腰围、女性年龄等因素有关（r =0.150~0.269, P均＜0.01）。男性受教育程度1～5年组及女性未受教育组血尿酸水平最高,分别为（411.4±91.2） ?滋mol/L和（330.8±78.6） ?滋mol/L。未受教育组HUA的患病率最高（33.6%）,受教育程度6～10年组最低（22.4%,P ＜0.01）。在男性以无工作组血尿酸水平最高,在女性以家务工作组血尿酸水平最高,分别为（418.9±107.6） ?滋mol/L和（317.2±76.2） ?滋mol/L。无工作组HUA患病率最高（41.0%）,体力工作组最低（17.8%,P ＜0.01）。饮酒和吸烟对尿酸水平也有显著影响,每天饮酒者和既往吸烟者尿酸水平最高,分别为（399.0±97.9） ?滋mol/L和（408.3±94.6） ?滋mol/L。慢性肾脏疾病（CKD）和高血压患者HUA患病率较高,分别为29.0%和32.0%,平均尿酸水平分别为（354.7±103.6） ?滋mol/L和（356.1±93.9） ?滋mol/L；而糖尿病患者与非糖尿病者HUA患病率无显著差异（χ2=0.957,P ＞0.05）。结论　广西城市社区居民HUA患病率较高,减轻体重、控制肥胖、避免吸烟、限制饮酒等生活方式的改变可能是有效的防治措施。
Abstract:
Objective　To explore the incidence of hyperuricemia （HUA） in the urban community residents and the related risk factors, and to propose some effective prevention measures．Methods　Totally 6 273 urban residents, aged 18-75 years, were screened with cross-sectional analysis in Xiangshan district of community Guilin.Fasting venous blood samples and urine were collected to evaluate blood glucose,renal function,urine routine,urinary albumin,etc.And questionnaire and physical examination were performed at the same time. Results　The total incidence of HUA was 23.5% in the urban community residents,and was 28.4% in males,which was significantly higher than 19.7% in females（χ2=1 332.576,P＜0.01）.The serum uric acid levels were positive related to weight（or body mass index）,waist circumference and female age when adjusting serum creatinine （r =0.150-0.269, all P＜0.01）. The serum uric acid levels in males received 1 to 5 years education and uneducated females were highest,which were（411.4±91.2） ?滋mol/L and（330.8±78.6） ?滋mol/L,respectively.The incidence of HUA in uneducated group was highest （33.6% ）,while lowest in 6 to 10 years education group （22.4%, P＜0.01）. The serum uric acid levels in males without work and in females engaged in housework were highest,which were （418.9±107.6） ?滋mol/L and（317.2±76.2） ?滋mol/L, respectively.The incidence of HUA in residents without work was highest（41.0%）,while lowest in residents engaged in physical work（17.8%, P＜0.01）.Alcohol consumption and smoke influenced significantly on uric acid level,and highest uric acid levels were in the residents frequently drunk [（399.0±97.9） ?滋mol/L] and smoked in the past [（408.3±94.6） ?滋mol/L]．Patients with chronic kidney disease and hypertension had high incidences of HUA ,which were 29.0% and 32.0%,respectively. The mean serum uric acid levels were（354.7±103.6）?滋mol/L and（356.1±93.9）?滋mol/L in these patients.There was no significant difference of the incidences of HUA be-tween patients with and without diabetes（χ2=0.957,P ＞0.05）.Conclusion　In the urban community residents of Guangxi,the incidence of HUA is high,and changing lifestyle such as losing weight,controlling obesity,avoiding smoke and restricting alcohol will be effective measures.

参考文献/References:

[1]　Levey AS,Eckardt KU,Tsukamoto Y,et al．Definition and classification of chronic kidney disease：a position statement from Kidney Disease：Improving Global Outcomes（KDIGO）[J]．Kidney Int,2005,67（6）：2089-2100.
[2]　Nan H,Qiao Q,Dong Y,et al．The prevalence of hyperuricemia in a population of the coastal city of Qingdao,China[J]．J Rheumatol,2006,33（7）：1346-1350.
[3]　Chen LY,Zhu WH,Chen ZW,et al．Relationship between hyperuricemia and metabolic syndrome．J Zhejiang Univ Sci B 2007,8（8）：593-598.
[4]　刘力生．中国高血压防治指南2010[J]．中华高血压杂志,2011, 19（8）：701-743.
[5]　Ko YC,Wang TN,Tsai LY,et al．High prevalence of hyperur- icemia in adolescent Taiwan aborigines[J]．J Rheumatol,2002, 29（4）：837-842.
[6]　Chuang SY,Lee SC,Hsieh YT,et al．Trends in hyperuricemia and gout prevalence：Nutrition and Health Survey in Taiwan from 1993-1996 to 2005-2008[J]．Asia Pac J Clin Nutr,2011,20（2）：301-308.
[7]　Weitzman M,Cook S,Auinger P,et al．Tobacco smoke exposure is associated with the metabolic syndrome in adolescents[J]．Circulation,2005,112（6）：862-869.
[8]　Geslain-Biquez C,Vol S,Tichet J,et al．The metabolic syndrome in smokers．The DESIR study[J]．Diabetes Metab,2003,29（3）：226-234.
[9]　Liu L,Lou S,Xu K,et al．Relationship between lifestyle choices and hyperuricemia in Chinese men and women[J]．Clin Rheum,2013,32（2）：233-239.
[10]　Feig Daniel I．Hyperuricemia and hypertension[J]．Adv Chron Kidney Dis,2012,19（6）：377-385.
[11]　Feig DI,Kang DH,Johnson RJ．Uric acid and cardiovascular risk[J]．N Engl J Med,2008,359（17）：1811-1821.
[12]　Feig DI,Johnson RJ．Hyperuricemia in childhood primary hypertension[J]．Hypertension,2003,42（3）：247-252.
[13]　Yamamoto Y,Matsubara K,Igawa G,et al．Status of uric acid management in hypertensive subjects[J]．Hypertens Res,2007,30（6）： 549-554.
[14]　Nan H,Dong Y,Gao W,et al．Diabetes associated with a low serum uric acid level in a general Chinese population[J]．Diabetes Res Clin Pract,2007,76（1）：68-74.

相似文献/References:

[1]王靖宇,常宝成.高尿酸血症/痛风流行病学特点及危险因素[J].国际内分泌代谢杂志,2016,36(02):78.[doi:10.3760/cma.j.issn.1673-4157.2016.02.002]
　Wang Jingyu,Chang Baocheng..Epidemiological characteristics and risk factors of hyperuricemia/gout[J].International Journal of Endocrinology and Metabolism,2016,36(01):78.[doi:10.3760/cma.j.issn.1673-4157.2016.02.002]
[2]聂秀玲,李明珍,孙丽荣.高尿酸血症与非酒精性脂肪性肝病[J].国际内分泌代谢杂志,2016,36(02):89.[doi:10.3760/cma.j.issn.1673-4157.2016.02.004]
　Nie Xiuling,Li Mingzhen,Sun Lirong..Hyperuricemia and non-alcoholic fatty liver[J].International Journal of Endocrinology and Metabolism,2016,36(01):89.[doi:10.3760/cma.j.issn.1673-4157.2016.02.004]
[3]李明珍,聂秀玲,孙丽荣.高尿酸血症与糖代谢异常的关系[J].国际内分泌代谢杂志,2016,36(04):217.[doi:10.3760/cma.j.issn.1673-4157.2016.04.01]
　Li Mingzhen,Nie Xiuling,Sun Lirong.Relationship between hyperuricemia and abnormalities of glucose metabolism[J].International Journal of Endocrinology and Metabolism,2016,36(01):217.[doi:10.3760/cma.j.issn.1673-4157.2016.04.01]
[4]刘彤,杨亚娟.高尿酸血症与心房颤动的关系[J].国际内分泌代谢杂志,2016,36(04):220.[doi:10.3760/cma.j.issn.1673-4157.2016.04.02]
　Liu Tong,Yang Yajuan.Relationship between hyperuricemia and atrial fibrillation[J].International Journal of Endocrinology and Metabolism,2016,36(01):220.[doi:10.3760/cma.j.issn.1673-4157.2016.04.02]
[5]刘华英,顾丹阳,邵加庆.高尿酸血症与内皮功能障碍[J].国际内分泌代谢杂志,2016,36(06):412.[doi:10.3760/cma.j.issn.1673-4157.2016.06.14]
　Liu Huaying,Gu Danyang,Shao Jiaqing..Hyperuricemia and endothelial dysfunction[J].International Journal of Endocrinology and Metabolism,2016,36(01):412.[doi:10.3760/cma.j.issn.1673-4157.2016.06.14]
[6]曹雯,孙洪平,褚晓秋,等.生活方式干预与高尿酸血症[J].国际内分泌代谢杂志,2017,37(03):172.[doi:10.3760/cma.j.issn.1673-4157.2017.03.007]
　Cao Wen,Sun Hongping,Chu Xiaoqiu,et al.Lifestyle intervention and hyperuricemia[J].International Journal of Endocrinology and Metabolism,2017,37(01):172.[doi:10.3760/cma.j.issn.1673-4157.2017.03.007]
[7]冯露文,成志锋.尿酸转运蛋白及其相互作用蛋白在尿酸代谢中的作用研究进展[J].国际内分泌代谢杂志,2021,41(03):220.[doi:10.3760/cma.j.cn121383-20200608-06017]
　Feng Luwen,Cheng Zhifeng..Research progress on the role of uric transporters and its protein interaction in uric acid metabolism[J].International Journal of Endocrinology and Metabolism,2021,41(01):220.[doi:10.3760/cma.j.cn121383-20200608-06017]
[8]牛紫如,陆强.高尿酸血症与不良妊娠结局[J].国际内分泌代谢杂志,2022,42(02):142.[doi:10.3760/cma.j.cn121383-20201114-11029]
　Niu Ziru,Lu Qiang..Hyperuricemia and adverse pregnancy outcomes[J].International Journal of Endocrinology and Metabolism,2022,42(01):142.[doi:10.3760/cma.j.cn121383-20201114-11029]
[9]吴丹,李竹.H型高血压患者血尿酸与左心室重构的关系[J].国际内分泌代谢杂志,2023,43(02):91.[doi:10.3760/cma.j.cn121383-20211129-11083]
　Wu Dan,Li Zhu..Relationship between serum uric acid and left ventricular remodeling in patients with H-type hypertension[J].International Journal of Endocrinology and Metabolism,2023,43(01):91.[doi:10.3760/cma.j.cn121383-20211129-11083]

备注/Memo

备注/Memo:
基金项目：广西科学研究与技术开发计划资助项目（桂科攻0719- 006-2-29）；国际肾脏病学会-全球肾脏病发展委员会资助项目（ISN-COMGAN） 通信作者：邹贵勉,Email: zougm2004@126.com
更新日期/Last Update: 2014-01-20