[1]苏钢,洪娟,许继炜,等.桥本甲状腺炎患者外周血miR-454、miR-146a水平及意义探讨[J].国际内分泌代谢杂志,2022,42(03):174-178.[doi:10.3760/cma.j.cn121383-20210318-03048]
　Su Gang,Hong Juan,Xu Jiwei,et al.Levels and significance of miR-454 and miR-146a in peripheral blood of patients with Hashimoto's thyroiditis[J].International Journal of Endocrinology and Metabolism,2022,42(03):174-178.[doi:10.3760/cma.j.cn121383-20210318-03048]
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桥本甲状腺炎患者外周血miR-454、miR-146a水平及意义探讨()
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《国际内分泌代谢杂志》[ISSN:1673-4157/CN:12-1383/R]

卷:
42
期数:
2022年03期
页码:
174-178
栏目:
论著
出版日期:
2022-05-20

文章信息/Info

Title:
Levels and significance of miR-454 and miR-146a in peripheral blood of patients with Hashimoto's thyroiditis
作者:
苏钢; 洪娟; 许继炜; 宣小明
芜湖市第一人民医院全科医学科,芜湖 241000
Author(s):
Su Gang;  Hong Juan;  Xu Jiwei;  Xuan Xiaoming
Department of General Medicine, Wuhu First People's Hospital, Wuhu 241000, China
关键词:
桥本甲状腺炎;  miR-454;  miR-146a
Keywords:
Hashimoto's thyroiditis;  miR-454;  miR-146a
DOI:
10.3760/cma.j.cn121383-20210318-03048
摘要:
目的 探究桥本甲状腺炎(HT)患者外周血miR-454、miR-146a水平及意义。方法 选取2018年1月至2020年6月来芜湖市第一人民医院就诊的桥本甲状腺炎患者56例作为HT组,并根据甲状腺功能分成甲状腺功能正常(HT-A组)16例,亚临床甲状腺功能减退(HT-B组)19例,临床甲状腺功能减退(HT-C组)21例,同期选取体检健康者50名作为健康组,比较HT组与健康组的甲状腺功能[促甲状腺激素(TSH)、游离三碘甲状腺原氨酸(FT3)、游离甲状腺素(FT4)、甲状腺过氧化物酶抗体(TPOAb)、甲状腺球蛋白抗体(TgAb)]、及外周血miR-454、miR-146a表达水平,探究miR-454、miR-146a与HT病情的关系。结果 HT-A组、HT-B组、HT-C组外周血miR-454及miR-146a表达水平均高于健康组,随HT患者甲状腺功能减退而升高(P均<0.05); miR-454与TSH、TgAb、TPOAb均呈正相关,与FT3、FT4呈负相关(P<0.05); miR-146a与TSH、TgAb、TPOAb均呈正相关,与FT3、FT4呈负相关(P均<0.05)。结论 HT患者外周血中miR-146a及miR-454水平均较健康人高,miR-146a及miR-454可能与甲状腺功能减退相关。
Abstract:
Objective To explore the levels and significance of miR-454 and miR-146a in peripheral blood of patients with Hashimoto's thyroiditis(HT).Methods A total of 56 patients with HT treated in Wuhu First People's Hospital were enrolled as HT group between January 2018 and June 2020. According to thyroid function status, they were divided into normal thyroid function group(HT-A group, 16 cases), subclinical hypothyroidism group(HT-B group, 19 cases)and clinical hypothyroidism group(HT-C group, 21 cases). A total of 50 healthy controls during the same period were enrolled as healthy group. The thyroid function [thyroid stimulating hormone(TSH), free triiodothyronine(FT3), free thyroxine(FT4), thyroid peroxidase antibody(TPOAb), thyroglobulin antibody(TgAb)], expression levels of miR-454 and miR-146a in peripheral blood were compared between HT group and healthy group. The relationship between miR-454, miR-146a and HT condition was explored. Results The expression levels of peripheral blood miR-454 and miR-146a in HT-A group, HT-B group and HT-C group were higher than those in healthy group, which were increased with the decrease of thyroid function of HT patients(all P<0.05). The miR-454 and miR-146a were positively correlated with TSH, TgAb and TPOAb, while negatively correlated with FT3 and FT4(all P<0.05).Conclusion The levels of peripheral blood miR-146a and miR-454 in HT patients are higher than those in healthy people. The miR-454 and miR-146a may be related to hypothyroidism.

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备注/Memo

备注/Memo:
通信作者:苏钢,Email:huasheng8830@163.com
更新日期/Last Update: 2022-05-10