[1]吴婷 卢若谷 谷伟军 吕朝晖 母义明.垂体功能减退症与代谢综合征的相关性研究[J].国际内分泌代谢杂志,2022,42(01):12-16.[doi:10.3760/cma.j.cn121383-20211109-11033]
　Wu Ting,Lu Ruogu,Gu Weijun,et al.Study on correlation between hypopituitarism and metabolic syndrome[J].International Journal of Endocrinology and Metabolism,2022,42(01):12-16.[doi:10.3760/cma.j.cn121383-20211109-11033]
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垂体功能减退症与代谢综合征的相关性研究 ()
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《国际内分泌代谢杂志》[ISSN:1673-4157/CN:12-1383/R]

卷:
42
期数:
2022年01期
页码:
12-16
栏目:
论著
出版日期:
2022-01-20

文章信息/Info

Title:
Study on correlation between hypopituitarism and metabolic syndrome
作者:
吴婷1; 2 卢若谷3 谷伟军2 吕朝晖2 母义明2
1解放军医学院,北京 100853; 2解放军总医院第一医学中心内分泌科,北京 100853; 3解放军总医院医学创新研究部,医学大数据研究中心,北京 100853
Author(s):
Wu Ting1; 2;  Lu Ruogu3;  Gu Weijun2;  Lyu Zhaohui2;  Mu Yiming2. 1
Medical School of Chinese PLA, Beijing 100853, China; 2Department of Endocrinology, the First Medical Centre of PLA General Hospital, Beijing 100853, China; 3Department of Medical Innovation Research Division, Medical Big-data Research Center, Chinese PLA General Hospital, Beijing 100853, China
关键词:
垂体功能减退症;  代谢综合征;  肥胖
Keywords:
Hypopituitarism;  Metabolic syndrome;  Obesity
DOI:
10.3760/cma.j.cn121383-20211109-11033
摘要:
目的 评估垂体功能减退症患者代谢综合征(metabolic syndrome,MS)及其各组分的患病率。方法 收集2009年10月至2020年10月于解放军总医院第一医学中心内分泌科就诊的1 850例诊断为垂体功能减退症成年患者的激素水平和代谢指标等相关临床资料,将其按照性别、年龄及不同激素水平进行分组,评估各组患者MS及其各组分患病率的差异。结果 垂体功能减退症患者中,MS的患病率为27.7%,其中发生高血压的比例最高。男性垂体功能减退症患者MS的患病率和女性患者之间无显著性差异,但MS各组分存在性别差异。合并MS的垂体功能减退症患者年龄大于不合并MS的患者(P<0.01)。随着年龄的增长,垂体功能减退症患者的空腹血糖、收缩压水平逐渐升高。中枢性肾上腺皮质功能不全患者MS的患病率最高,中枢性甲状腺功能减退患者的MS患病率最低。结论 垂体功能减退症患者MS的患病率高于普通人群,其MS及各组分的患病率可能受到性别、年龄及激素水平的影响。
Abstract:
Objective To evaluate the prevalence of metabolic syndrome(MS)and its components in hypopituitarism patients.Methods The clinical data of hormone levels and metabolic indicators of 1 850 patients diagnosed with hypopituitarism who were admitted to the Department of Endocrinology of the First Medical Centre of PLA General Hospital from October 2009 to October 2020 were collected. They were divided into groups according to gender, age and different hormone levels. The prevalence of MS and its components were analyzed in each group.Results The prevalence of MS in hypopituitarism patients was 27.7%, with the highest incidence of hypertension. There was no significant difference in the prevalence of MS between male hypopituitarism patients and female patients, but there were gender differences in its components.The patients with hypopituitarism complicated with MS were older than those without MS(P<0.01).With the increase of age, the fasting blood glucose and systolic blood pressure were gradually increased in hypopituitarism patients. The prevalence of MS was highest in patients with central adrenal insufficiency and lowest in patients with central hypothyroidism.Conclusion The prevalence of MS in hypopituitarism patients is higher than that in the general population, and the prevalence of MS and its components may be affected by gender, age and hormone levels.

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备注/Memo

备注/Memo:
通信作者:谷伟军,Email:guweijun301@163.com
更新日期/Last Update: 2022-01-20