[1]柯晓安,龚凤英,朱惠娟,等.巨催乳素血症及检测方法的研究进展[J].国际内分泌代谢杂志,2021,41(03):203-206.[doi:10.3760/cma.j.cn121383-20200423-04062]
 Ke Xiaoan,Gong Fengying,Zhu Huijuan..Research progress of macroprolactinemia and detection methods[J].International Journal of Endocrinology and Metabolism,2021,41(03):203-206.[doi:10.3760/cma.j.cn121383-20200423-04062]
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巨催乳素血症及检测方法的研究进展()
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《国际内分泌代谢杂志》[ISSN:1673-4157/CN:12-1383/R]

卷:
41
期数:
2021年03期
页码:
203-206
栏目:
论著
出版日期:
2021-05-20

文章信息/Info

Title:
Research progress of macroprolactinemia and detection methods
作者:
柯晓安龚凤英朱惠娟
中国医学科学院,北京协和医学院,北京协和医院内分泌科,国家卫生健康委员会内分泌重点实验室,协和转化医学中心,疑难重症及罕见病国家重点实验室 100730
Author(s):
Ke Xiaoan Gong Fengying Zhu Huijuan.
State Key Laboratory of Complex Severe and Rare Diseases, the Translational Medicine Center,Key Laboratory of Endocrinology of National Health Commission, Department of Endocrinology, Peking Union Medical College Hospital, Chinese Academy of Medical Scien
关键词:
高催乳素血症 巨催乳素血症 聚乙二醇沉淀法 超滤法
Keywords:
Hyperprolactinemia Macroprolactinemia Polyethylene glycol precipitation Ultrafiltration
DOI:
10.3760/cma.j.cn121383-20200423-04062
摘要:
血清催乳素分子主要有3种不同存在形式,包括单体催乳素(23 kD)、大催乳素(40~60 kD)和与免疫球蛋白G(IgG)结合的巨催乳素分子(150 kD)。巨催乳素分子生物活性低但有免疫活性。巨催乳素血症是高催乳素血症(HPRL)的常见原因之一,常被误诊为催乳素瘤而过度诊疗。血清巨催乳素检测方法包括凝胶过滤层析法、聚乙二醇(polyethylene glycol,PEG)沉淀法和超滤法,除PEG沉淀法在英国常规用于临床检测巨催乳素血症,国内外临床上未广泛开展。本文就高催乳素血症中巨催乳素血症及检测方法相关问题进行综述,以加强临床医生对巨催乳素血症的认识和提高诊疗水平。
Abstract:
There are three main forms of prolactin in serum, including monomeric prolactin(23 kD), bigprolactin(40-60 kD)and macroprolactin(150 kD)combined with immunoglobulin G(IgG). Macroprolactin has immunological activity but low biological activity. Macroprolactinemia is one of the common causes of hyperprolactinemia, which is often misdiagnosed as prolactinoma and overtreated. Serum macroprolactin detection methods mainly include gel filtration chromatography(GFC), polyethylene glycol(PEG)precipitation and ultrafiltration. Except for PEG precipitation that is routinely used in clinical screening in the United Kingdom, macroprolactin detection has not been widely carried out in clinical practice at home and abroad. This review summarizes the issue of macroprolactinemia and its detection in patients with hyperprolactinemia to strengthen clinicians' understanding and achieve accurate diagnosis and treatment.

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备注/Memo

备注/Memo:
通信作者:朱惠娟,Email:shengxin2004@163.com 基金项目:中国医学科学院中央级公益性科研院所基本科研业务费临床与转化医学研究基金项目(2019XK320005)
更新日期/Last Update: 2021-05-20