[1]詹永颖,黄汉伟.益生菌对妊娠期糖尿病的影响及相关机制[J].国际内分泌代谢杂志,2021,41(02):124-127.[doi:10.3760/cma.j.cn121383-20200821-08037]
 Zhan Yongying,Huang Hanwei..Effects and mechanism of probiotics on gestational diabetes mellitus[J].International Journal of Endocrinology and Metabolism,2021,41(02):124-127.[doi:10.3760/cma.j.cn121383-20200821-08037]
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益生菌对妊娠期糖尿病的影响及相关机制()
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《国际内分泌代谢杂志》[ISSN:1673-4157/CN:12-1383/R]

卷:
41
期数:
2021年02期
页码:
124-127
栏目:
综述
出版日期:
2021-03-20

文章信息/Info

Title:
Effects and mechanism of probiotics on gestational diabetes mellitus
作者:
詹永颖1黄汉伟2
1广东医科大学研究生学院,湛江 524000; 2广东医科大学附属中山医院内分泌科,中山 528415
Author(s):
Zhan Yongying1 Huang Hanwei2.
1Graduate School of Guangdong Medical University, Zhanjiang 524000, China; 2Department of Endocrinology, Affiliated Zhongshan Hospital of Guangdong Medical University, Zhongshan 528415, China
关键词:
妊娠期糖尿病 肠道菌群 益生菌
Keywords:
Gestational diabetes mellitus Intestinal flora Probiotics
DOI:
10.3760/cma.j.cn121383-20200821-08037
摘要:
妊娠期糖尿病(gestational diabetes mellitus, GDM)可对母体及其后代产生近期和远期的不良影响,GDM患者的肠道菌群与正常孕妇存在差异,肠道菌群结构及功能的改变影响了其发生发展。近年来,国外研究发现,益生菌可不同程度地影响GDM患者糖脂代谢,但具体机制不甚明确,短链脂肪酸、过氧化物酶体增殖物激活受体、肝脏自然杀伤T细胞等或在益生菌和这些临床指标之间起到了桥梁作用。合理且适当地补充食用益生菌有望成为妊娠期糖尿病血糖管理的新靶点。
Abstract:
Gestational diabetes mellitus has short-term and long-term adverse effects on mothers and their offspring. The intestinal flora of patients with gestational diabetes mellitus is different from that of normal pregnant women. Changes in the structure and function of the intestinal flora affect its occurrence and development. In recent years, foreign studies have found that probiotics can affect glucose and lipid metabolism in patients with gestational diabetes mellitus to varying degrees, but the specific mechanism has not been fully elucidated. The activation of short-chain fatty acids, peroxisome proliferators-activated receptors and the natural killer T cells of the liver may act as a bridge between probiotics and these indicators. Reasonable and appropriate supplementation of probiotics is expected to become a new target for blood glucose management in gestational diabetes mellitus.

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备注/Memo

备注/Memo:
通信作者:黄汉伟,Email:huanghw662@163.com 基金项目:2020年度中山市第一批社会公益与基础研究项目(2020B1125)
更新日期/Last Update: 2021-03-20