[1]张君宜 徐慧蔚 孙航 曲伸.代谢性手术对阻塞性睡眠呼吸暂停综合征的治疗作用[J].国际内分泌代谢杂志,2019,39(04):245-247252.[doi:10.3760/cma.j.issn.1673-4157.2019.04.007]
　Zhang Junyi,Xu Huiwei,Sun Hang,et al.Effect of metabolic surgery in the treatment of obstructive sleep apnea syndrome[J].International Journal of Endocrinology and Metabolism,2019,39(04):245-247252.[doi:10.3760/cma.j.issn.1673-4157.2019.04.007]
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代谢性手术对阻塞性睡眠呼吸暂停综合征的治疗作用()
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《国际内分泌代谢杂志》[ISSN:1673-4157/CN:12-1383/R]

卷:
39
期数:
2019年04期
页码:
245-247252
栏目:
综述
出版日期:
2019-07-20

文章信息/Info

Title:
Effect of metabolic surgery in the treatment of obstructive sleep apnea syndrome
作者:
张君宜1 徐慧蔚2 孙航1 曲伸1
1同济大学附属上海市第十人民医院内分泌科 200072; 2海门市人民医院内分泌科 226100 张君宜与徐慧蔚对本文有同等贡献
Author(s):
Zhang Junyi1;  Xu Huiwei2;  Sun Hang1;  Qu Shen1
1Department of Endocrinology, Shanghai Tenth People's Hospital, Tongji University, Shanghai 200072, China; 2Department of Endocrinology, Haimen People's Hospital, Haimen 226100, China Zhang Junyi and Xu Huiwei are contributed equally to this article
关键词:
代谢性手术;  阻塞性睡眠呼吸暂停综合征;  肥胖
Keywords:
Obstructive sleep apnea syndrome;  Metabolic surgery;  Obesity
DOI:
10.3760/cma.j.issn.1673-4157.2019.04.007
摘要:
近年来,阻塞性睡眠呼吸暂停综合征(OSAS)的发病率逐渐增多,已成为严重影响人们身心健康的公共问题,在肥胖患者中尤为严重。肥胖与OSAS经常相伴发生,互为因果。代谢性手术不仅可用于治疗肥胖,也可作为治疗OSAS的有效手段。代谢性手术给重度肥胖患者和肥胖2型糖尿病患者的治疗都带来了根本性转变,同时对OSAS患者也具有良好的治疗作用。其主要作用机制可能是通过体重依赖性效应、非体重依赖性的代谢效应、减少机体慢性炎性反应及调节增食欲素与瘦素水平等来实现的。
Abstract:
In recent years, the incidence of obstructive sleep apnea syndrome(OSAS)has gradually increased, which has become a public health problem and seriously affect people's physical and mental health, especially among obese patients. Obesity and OSAS often exist at the same time and become the reason for each other, and metabolic surgery can be used not only for obesity, but also as an effective means of OSAS. Besides, metabolic surgery has brought fundamental changes to patients with morbid obesity and obese patients with type 2 diabetes. At the same time, it also has a good impact on patients with OASA. The main mechanisms may include the weight-dependent and non-weight-dependent metabolic effects, the improvement of chronic inflammatory status and regulation of orexin and leptin levels.

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备注/Memo

备注/Memo:
通信作者:曲伸,Email:qushencn@hotmail.com
Corresponding author: Qu Shen, Email: qushencn@hotmail.com
基金项目:国家重点研发计划(2018YFC1314100); 上海市科委项目(17DZ1910603); 上海市领军人才项目(049)
Fund program:National Key R&D Program of China(2018YFC1314100); Shanghai Committee of Science and Technology, China(17DZ1910603); Shanghai Municipality: Shanghai Outstanding Academic Leaders Plan(049)
更新日期/Last Update: 2019-11-29