[1]王香青 马振军 孔方方.外泌体与妊娠糖尿病[J].国际内分泌代谢杂志,2019,39(03):194-197.[doi:10.3760/cma.j.issn.1673-4157.2019.03.012]
 Wang Xiangqing,Ma Zhenjun,Kong Fangfang.Exosomes and gestational diabetes mellitus[J].International Journal of Endocrinology and Metabolism,2019,39(03):194-197.[doi:10.3760/cma.j.issn.1673-4157.2019.03.012]
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外泌体与妊娠糖尿病()
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《国际内分泌代谢杂志》[ISSN:1673-4157/CN:12-1383/R]

卷:
39
期数:
2019年03期
页码:
194-197
栏目:
综述
出版日期:
2019-05-20

文章信息/Info

Title:
Exosomes and gestational diabetes mellitus
作者:
王香青 马振军 孔方方
中国人民解放军464医院妇产科,天津 300381
Author(s):
Wang Xiangqing Ma Zhenjun Kong Fangfang
Department of Obstetrics and Gynecology, 464 Hospital of People's Liberation Army of China, Tianjin 300381, China
关键词:
外泌体 妊娠糖尿病 内皮细胞
Keywords:
Exosome Gestational diabetes mellitus Endothelial cells
DOI:
10.3760/cma.j.issn.1673-4157.2019.03.012
摘要:
外泌体是纳米大小的颗粒,直径为50~120 nm,参与细胞间的信息传递。研究显示,与正常妊娠女性相比,妊娠糖尿病患者血浆胎盘来源的外泌体水平升高。妊娠时高糖、低氧、肥胖参与诱导外泌体释放增加。外泌体作为生物标志物,可能用于诊断妊娠糖尿病。同时,外泌体还可通过影响内皮细胞L-精氨酸/一氧化氮信号通路、内皮激活、氧化应激以及通过microRNA调节基因表达,进一步影响妊娠糖尿病患者的内皮功能。对外泌体与妊娠糖尿病相关性的深入研究,将为妊娠糖尿病的诊断与治疗提供新的靶点。
Abstract:
Exosomes are nanovesicles(50-120 nm diameter), which are involved in cell-cell communication. Studies have showed that compared with normal pregnant women, plasma exosomes derived from placenta were increased in women with gestational diabetes mellitus(GDM). Hyperglycemia, hypoxia, obesity during pregnancy could induce the release of exosomes. As a biologic marker, exosome may be used to diagnose GDM. Meanwhile, exosomes might further influence the development of GDM by influencing the L-arginine/nitric oxide signaling pathway, endothelial activation, oxidative stress in endothelial cells, and regulating gene expression by microRNA. Further study of the relationship between exosomes and GDM, will provide a novel target for diagnosis and treatment of GDM.

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备注/Memo

备注/Memo:
通信作者:孔方方,Email:kongff464@126.com
Corresponding author: Kong Fangfang, Email: kongff464@126.com
更新日期/Last Update: 2019-05-20