[1]张会峰 胡天赤 陈学勤 叶向荣 刘超.丙型肝炎病毒感染与自身免疫性甲状腺疾病 及甲状腺癌风险[J].国际内分泌代谢杂志,2019,39(02):128-130.[doi:10.3760/cma.j.issn.1673-4157.2019.02.014]
 Zhang Huifeng,Hu Tianchi,Chen Xueqin,et al.Relationship between hepatitis C virus infection and the risk of autoimmune thyroid diseases and thyroid cancer[J].International Journal of Endocrinology and Metabolism,2019,39(02):128-130.[doi:10.3760/cma.j.issn.1673-4157.2019.02.014]
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丙型肝炎病毒感染与自身免疫性甲状腺疾病 及甲状腺癌风险()
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《国际内分泌代谢杂志》[ISSN:1673-4157/CN:12-1383/R]

卷:
39
期数:
2019年02期
页码:
128-130
栏目:
综述
出版日期:
2019-03-20

文章信息/Info

Title:
Relationship between hepatitis C virus infection and the risk of autoimmune thyroid diseases and thyroid cancer
作者:
张会峰1 胡天赤2 陈学勤3 叶向荣2 刘超1
1南京中医药大学附属中西医结合医院内分泌代谢病院区 210028; 2厦门市中医院内分泌科 361001; 3厦门市中医院 361001张会峰和胡天赤对本文有同等贡献
Author(s):
Zhang Huifeng1 Hu Tianchi2 Chen Xueqin3 Ye Xiangrong2 Liu Chao1
1Department of Endocrinology and Metabolism, Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Traditional Chinese Medicine, Nanjing 210028, China; 2Department of Endocrinology and Metabolism, Xiamen Hospital of Chinese Medicine, Xiamen 361001, China; 3Xiamen Hospital of Chinese Medicine, Xiamen 361001, China Zhang Huifeng and Hu Tianchi are contributed equally to this article
关键词:
自身免疫性甲状腺疾病 甲状腺癌 丙型肝炎
Keywords:
Autoimmune thyroid diseases Thyroid cancer Hepatitis C
DOI:
10.3760/cma.j.issn.1673-4157.2019.02.014
摘要:
研究显示,在丙型肝炎病毒感染的人群中,自身免疫性甲状腺疾病与甲状腺癌的患病率显著增加,尤其是女性患者。其机制可能是病毒感染导致的自身抗原表达,或隐性抗原表位的识别; 病毒导致的局部炎性反应而释放的细胞因子引起的自身反应性T细胞的旁观活化; 病毒抗原和甲状腺抗原之间发生分子模拟或交叉反应; 热休克蛋白在甲状腺的表达; 甲状腺细胞导致的主要组织相容性复合体Ⅱ类分子异常表达。其增加甲状腺癌的风险可能与其引起免疫系统紊乱而增加免疫性甲状腺炎的风险相关。
Abstract:
Studies have shown that, the prevalence of autoimmune thyroid disease and thyroid cancer has increased significantly among patients infected with hepatitis C, especially among women. The possible mechanisms include: changes in self antigen expression, or exposure of cryptic epitopes; local inflammation and cytokine release caused by virus, resulting in activation of autoreactive T cells by bystander mechanisms; molecular mimicry or cross-reactivity which may occur between viral antigens and thyroidal antigens; heat shock proteins expression in thyroid gland; abnormal expression of major histocompatibility complex class Ⅱ molecules by thyrocytes. And the mechanism of which increases the risk of thyroid cancer may be associated with the increased risk of immune thyroiditis due to abnormal immune system.

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备注/Memo

备注/Memo:
通信作者:叶向荣, Email:13606030826@163.com; 刘超, Email:profliuchao@163.com
Corresponding author: Ye Xiangrong, Email:13606030286@163.com; Liu Chao, Email:profliuchao@163.com
更新日期/Last Update: 2019-03-20