[1]吴美瑶,夏维波.骨钙素对青春发育的作用[J].国际内分泌代谢杂志,2017,37(06):394-397.
　Wu Meiyao,Xia Weibo..Roles of osteocalcin in the development of puberty[J].International Journal of Endocrinology and Metabolism,2017,37(06):394-397.
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骨钙素对青春发育的作用()
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《国际内分泌代谢杂志》[ISSN:1673-4157/CN:12-1383/R]

卷:
37
期数:
2017年06期
页码:
394-397
栏目:
综述
出版日期:
2017-11-20

文章信息/Info

Title:
Roles of osteocalcin in the development of puberty
作者:
吴美瑶; 夏维波
100730 北京,中国医学科学院,北京协和医学院,北京协和医院内分泌科,国家卫生和计划生育委员会(卫生部)内分泌重点实验室
Author(s):
Wu Meiyao;  Xia Weibo.
Department of Endocrinology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Key Laboratory of Endocrinology, Nation of Health and Family Planning Commision of the People's Republic of China, Beijing 100730, China
关键词:
骨钙素;  青春发育;  下丘脑-垂体-性腺轴
Keywords:
Osteocalcin;  Adolescent development;  Hypothalamic-pituitary-gonadal axis
文献标志码:
A
摘要:
骨钙素影响睾酮的合成与分泌,因而亦会对男性青春发育的各方面产生影响,如性腺发育、精细胞凋亡及生长激增等,其在间质细胞上的相关受体及下游信号通路已得到了初步阐明。但尚未有证据支持骨钙素会对女性青春发育产生影响。同时,骨骼-睾丸正反馈系统的提出,对传统的下丘脑-垂体-性腺轴系统进行了补充,也为青春期相关疾病的研究和治疗提供了新的思路。
Abstract:
Osteocalcin has been proved to influence the synthesis and secretion of testosterone, and to play a unique role in male puberty development in many aspects, including gonadal development, spermatozoa apoptosis and growth spurt. The receptor for osteocalcin which is expressed in leydig cells and its downstream signaling pathway have been identified. But there is no evidence to support osteocalcin will affect the female puberty development. The bone-testis positive feedback axis, a supplement to the traditional hypothalamic-pituitary-gonadal axis system, provides a new perspective on the research and treatment of puberty related disease.

参考文献/References:

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备注/Memo

备注/Memo:
基金项目:国家自然科学基金资助项目(81670714)
通信作者:夏维波,Email:xiaweibo@medmail.com.cn
更新日期/Last Update: 2017-11-30