[1]冯静,魏亚聪,宋光耀.成纤维细胞生长因子21与胰岛素抵抗[J].国际内分泌代谢杂志,2015,(04):268-270.[doi:10.3760/cma.j.issn.1673-4157.2015.04.015]
　Feng Jing*,Wei Yacong,Song Guangyao..Fibroblast growth factor 21 and insulin resistance[J].International Journal of Endocrinology and Metabolism,2015,(04):268-270.[doi:10.3760/cma.j.issn.1673-4157.2015.04.015]
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成纤维细胞生长因子21与胰岛素抵抗()
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《国际内分泌代谢杂志》[ISSN:1673-4157/CN:12-1383/R]

卷:
期数:
2015年04
页码:
268-270
栏目:
综述
出版日期:
2015-07-20

文章信息/Info

Title:
Fibroblast growth factor 21 and insulin resistance
作者:
冯静; 魏亚聪; 宋光耀
050017　石家庄，河北医科大学研究生学院（冯静，魏亚聪），内科学教研室（宋光耀）；050051　石家庄，河北省人民医院内分泌科 （宋光耀）
Author(s):
Feng Jing*; Wei Yacong; Song Guangyao.
*Graduate Institute of Hebei Medical University，Shijiazhuang 050017，China Corresponding author：Song Guangyao，Email：sguangyao2@163.com
关键词:
成纤维细胞生长因子21; 胰岛素抵抗; 胰岛素敏感性; 线粒体氧化
Keywords:
Fibroblast growth factor 21; Insulin resistance; Insulin sensitivity; Mitochondrial oxidation
DOI:
10.3760/cma.j.issn.1673-4157.2015.04.015
摘要:
研究表明，成纤维细胞生长因子21（FGF21）可以改善胰岛素抵抗、增加胰岛素敏感性。其通过保护胰岛β细胞、与胰岛素协同、增强线粒体氧化、促进脂联素分泌等发挥作用。脑室内给予FGF21也可改善胰岛素敏感性。FGF21为治疗2型糖尿病、肥胖等疾病带来了新方向。
Abstract:
Studies show that fibroblast growth factor 21（FGF21） plays an important role in improving insulin resistance and increasing insulin sensitivity. FGF21 can protect islet ?茁 cells，synergize with insulin，enhance mitochondrial oxidation and promote the secretion of adiponectin. Intracere-broventricular infusion of FGF21 can also improve insulin sensitivity. FGF21 provides a new way for the treatment of type 2 diabetes，obesity and so on.

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备注/Memo

备注/Memo:
通信作者：宋光耀，Email：sguangyao2@163.com
更新日期/Last Update: 2015-07-20