[1]王思倩,吴锦丹.肠促胰素对1型糖尿病患者血糖及胰岛功能的影响[J].国际内分泌代谢杂志,2015,(03):196-198.[doi:10.3760/cma.j.issn.1673-4157.2015.03.015]
 Wang Siqian,Wu Jindan..Effects of incretin on blood glucose and islet function in type 1 diabetic patients[J].International Journal of Endocrinology and Metabolism,2015,(03):196-198.[doi:10.3760/cma.j.issn.1673-4157.2015.03.015]
点击复制

肠促胰素对1型糖尿病患者血糖及胰岛功能的影响()
分享到:

《国际内分泌代谢杂志》[ISSN:1673-4157/CN:12-1383/R]

卷:
期数:
2015年03
页码:
196-198
栏目:
综述
出版日期:
2015-05-20

文章信息/Info

Title:
Effects of incretin on blood glucose and islet function in type 1 diabetic patients
作者:
王思倩吴锦丹
210006 南京医科大学附属南京医院(南京市第一医院)内分泌科   
Author(s):
Wang SiqianWu Jindan.
Department of Endocrinology,Nanjing First Hospital,Nanjing Medical University,Nanjing 210006,China Corresponding author:Wu Jindan,Email: wujindandan@sina.com
关键词:
GLP-1类似物DPP-4抑制剂1型糖尿病血糖胰岛功能
Keywords:
GLP-1 analoguesDPP-4 inhibitorsType 1 diabetes mellitusBlood glucoseIslet cell function
DOI:
10.3760/cma.j.issn.1673-4157.2015.03.015
摘要:
肠促胰素类药物因其葡萄糖依赖性的降糖作用及对胰岛细胞的保护作用受到广泛关注。近年研究发现,肠促胰素类药物不仅可降低1型糖尿病患者的血糖,改善血糖波动,还可以改善患者胰岛功能,减少氧化应激对胰岛细胞的损害,从而有助于患者的整体血糖的控制,延缓并发症的发生。
Abstract:
Incretin has obtained more and more attention because of its glucose-dependent blood glucose lowering effects and its islet protection. Recently it is found that incretin-based drugs can lower blood glucose and improve blood glucose fluctuation in patients with type 1 diabetes. It can also improve islet function,and reduce the damage of oxidative stress to islet cells,which are helpful for the long term control of blood glucose and the delay of diabetic complications.

参考文献/References:

[1] Kramer CK,Borgono CA,Van Nostrand P,et al.Glucagon response to oral glucose challenge in type 1 diabetes:lack of impact of euglycemia[J].Diabetes Care,2014,37(4):1076-1082.  
[2] Downie E,Craig ME,Hing S,et al.Continued reduction in the prevalence of retinopathy in adolescents with type 1 diabetes:role of insulin therapy and glycemic control[J].Diabetes Care,2011,34(11):2368-2373.  
[3] Wood JR,Miller KM,Maahs DM,et al.Most youth with type 1 diabetes in the T1D Exchange Clinic Registry do not meet American Diabetes Association or International Society for Pediatric and Adolescent Diabetes clinical guidelines[J].Diabetes Care,2013,36(7):2035-2037.  
[4] Kuhadiya ND,Malik R,Bellini NJ,et al.Liraglutide as additional treatment to insulin in obese patients with type 1 diabetes mellitus[J].Endocr Pract,2013,19(6):963-967.  
[5] Traina AN,Lull ME,Hui AC,et al.Once-weekly exenatide as adjunct treatment of type 1 diabetes mellitus in patients receiving continuous subcutaneous insulin infusion therapy[J].Can J Diabetes,2014,38(4):269-272.  
[6] Farngren J,Persson M,Schweizer A,et al.Vildagliptin reduces glucagon during hyperglycemia and sustains glucagon counter-regulation during hypoglycemia in type 1 diabetes[J].J Clin Endocrinol Metab,2012,97(10):3799-3806.  
[7] Ellis SL,Moser EG,Snell-Bergeon JK,et al.Effect of sitagliptin on glucose control in adult patients with type 1 diabetes:a pilot,double-blind,randomized,crossover trial[J].Diabet Med,2011,28(10):1176-1181.  
[8] Morrow L,Hompesch M,Guthrie H,et al.Co-administration of liraglutide with insulin detemir demonstrates additive pharma-codynamic effects with no pharmacokinetic interaction[J].Diabetes Obes Metab,2011,13(1):75-80.  
[9] Renukuntla VS,Ramchandani N,Trast J,et al.Role of glucagon-like peptide-1 analogue versus amylin as an adjuvant therapy in type 1 diabetes in a closed loop setting with ePID algorithm[J].J Diabetes Sci Technol,2014,8(5):1011-1017.
[10] Patel V,Joharapurkar A,Dhanesha N,et al.Combination of omeprazole with GLP-1 agonist therapy improves insulin sensi-tivity and antioxidant activity in liver in type 1 diabetic mice[J].Pharmacol Rep,2013,65(4):927-936.
[11] Sarkar G,Alattar M,Brown RJ,et al.Exenatide treatment for 6 months improves insulin sensitivity in adults with type 1 diabetes[J]. Diabetes Care,2014,37(3):666-670.
[12] Deiss D,Diederich S,Kordonouri O.Successful treatment with liraglutide in type 1 diabetes and MODY[J].Dtsch Med Wochenschr,2011,136(21):1116-1120.
[13] Harrison LB,Mora PF,Clark GO,et al.Type 1 diabetes treatment beyond insulin:role of GLP-1 analogs[J].J Investig Med,2013, 61(1):40-44.
[14] Foley JE,Ligueros-Saylan M,He YL,et al.Effect of vildagliptin on glucagon concentration during meals in patients with type 1 diabetes[J].Horm Metab Res,2008,40(10):727-730.
[15] Varanasi A,Bellini N,Rawal D,et al.Liraglutide as additional treatment for type 1 diabetes[J].Eur J Endocrinol,2011,165(1):77-84.
[16] Kielgast U,Holst JJ,Madsbad S.Antidiabetic actions of endogenous and exogenous GLP-1 in type 1 diabetic patients with and without residual beta-cell function[J].Diabetes,2011,60(5):1599-1607.
[17] Ghazi T,Rink L,Sherr JL,et al.Acute metabolic effects of exenatide in patients with type 1 diabetes with and without residual insulin to oral and intravenous glucose challenges[J].Diabetes Care,2014,37(1):210-216.
[18] Creutzfeldt WO,Kleine N,Willms B,et al.Glucagonostatic actions and reduction of fasting hyperglycemia by exogenous glucagon-like peptide Ⅰ(7-36) amide in type Ⅰ diabetic patients[J].Diabetes Care,1996,19(6):580-586.
[19] Garg SK,Moser EG,Bode BW,et al.Effect of sitagliptin on post-prandial glucagon and GLP-1 levels in patients with type 1 diabetes:investigator-initiated,double-blind,randomized,placebo-controlled trial[J].Endocr Pract,2013,19(1):19-28.
[20] Suarez-Pinzon WL,Rabinovitch A.Combination therapy with a dipeptidyl peptidase-4 inhibitor and a proton pump inhibitor induces beta-cell neogenesis from adult human pancreatic duct cells implanted in immunodeficient mice[J].Cell Transplant,2011,20(9):1343-1349.
[21] Cechin SR,Pérez-?魣lvarez I,Fenjves E,et al.Anti-inflammatory properties of exenatide in human pancreatic islets[J].Cell Transplant,2012,21(4):633-648.
[22] Jelsing J,Vrang N,van Witteloostuijn SB,et al.The DPP4 inhibitor linagliptin delays the onset of diabetes and preserves beta-cell mass in non-obese diabetic mice[J].J Endocrinol,2012, 214(3):381-387.
[23] Cho JM,Jang HW,Cheon H,et al.A novel dipeptidyl peptidase Ⅳ inhibitor DA-1229 ameliorates streptozotocin-induced diabetes by increasing beta-cell replication and neogenesis[J].Diabetes Res Clin Pract,2011,91(1):72-79.
[24] Drews G,Krippeit-Drews P,Düfer M.Oxidative stress and beta-cell dysfunction[J].Pflugers Arch,2010,460(4):703-718.
[25] Zhao L,Guo H,Chen H,et al.Effect of liraglutide on endoplasmic reticulum stress in diabetes[J].Biochem Biophys Res Commun,2013,441(1):133-138.
[26] Ceriello A,Novials A,Ortega E,et al.Glucagon-like peptide 1 reduces endothelial dysfunction, inflammation, and oxidative stress induced by both hyperglycemia and hypoglycemia in type 1 diabetes[J]. Diabetes Care,2013,36(8):2346-2350.
[27] ?魣vila Dde L,Araújo GR,Silva M,et al.Vildagliptin ameliorates oxidative stress and pancreatic beta cell destruction in type 1 diabetic rats[J].Arch Med Res,2013,44(3):194-202.

相似文献/References:

[1]包薇萍,陈国芳,刘超.DPP-4抑制剂的肾保护作用[J].国际内分泌代谢杂志,2014,(05):337.[doi:10.3760/cma.j.issn.1673-4157.2014.05.014]
 Bao Weiping,Chen Guofang,Liu Chao..Renal protective effects of dipeptidyl peptidase-4 inhibitors[J].International Journal of Endocrinology and Metabolism,2014,(03):337.[doi:10.3760/cma.j.issn.1673-4157.2014.05.014]

备注/Memo

备注/Memo:
基金项目:南京市第三批科技发展计划项目(201303005) 通信作者:吴锦丹,Email:wujindandan@sina.com
更新日期/Last Update: 2015-05-20