[1]陈堃,刘超,陈国芳,等.糖尿病肾病诊断标志物研究进展[J].国际内分泌代谢杂志,2015,(03):176-179.[doi:10.3760/cma.j.issn.1673-4157.2015.03.009]
　Chen Kun,Liu Chao,Chen Guofang,et al.Urinary biomarkers for diabetic nephropathy[J].International Journal of Endocrinology and Metabolism,2015,(03):176-179.[doi:10.3760/cma.j.issn.1673-4157.2015.03.009]
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糖尿病肾病诊断标志物研究进展()
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《国际内分泌代谢杂志》[ISSN:1673-4157/CN:12-1383/R]

卷:
期数:
2015年03
页码:
176-179
栏目:
肾脏疾病专栏
出版日期:
2015-05-20

文章信息/Info

Title:
Urinary biomarkers for diabetic nephropathy
作者:
陈堃; 刘超; 陈国芳; 王昆
210028　南京中医药大学附属中西医结合医院，江苏省中西医结合医院内分泌代谢病院区
Author(s):
Chen Kun; Liu Chao; Chen Guofang; Wang Kun.
Endocrine and Diabetes Center，Jiangsu Province Hospital on Integration of Chinese and Western Medicine，Nanjing University of Traditional Chinese Medicine，Nanjing 210028，China Corresponding author：Liu Chao，Email：liuchao@nfmcn.com
关键词:
糖尿病肾病; 标志物; 肾小球损伤; 肾小管损伤; 微小RNA
Keywords:
Diabetic nephropathy; Biomarkers; Glomerular damage; Tubular damage; MicroRNAs
DOI:
10.3760/cma.j.issn.1673-4157.2015.03.009
摘要:
糖尿病肾病（DN）是造成终末期肾病的最常见原因，也是糖尿病患者发病率和死亡率显著增加的主要因素。早期诊断对DN的管理非常重要。尿微量白蛋白被认为是诊断早期DN的金标准，但具有一定的局限性。近年来发现了一些尿液中反映肾脏受损的新的标志物，包括肾小球损伤标志物（肾病蛋白、足细胞标记蛋白、肾母细胞瘤1基因），肾小管损伤标志物（中性粒细胞明胶酶相关载脂蛋白、肾脏损伤分子1）和炎性因子（肿瘤坏死因子受体）等。同时一些较新的方法如尿非编码RNA（微小RNA）及尿蛋白组学检测为诊断DN提供了新策略。
Abstract:
Diabetic nephropathy（DN） is the most common cause of end-stage kidney disease and accounts for a significant increase in morbidity and mortality in patients with diabetes. Early detection is critical in improving clinical management. Although microalbuminuria is regarded as the gold standard for diagnosing the onset of DN，its predictive power is limited. Recently，a number of novel urinary biomarkers have been identified and used to reflect kidney injury，such as biomarkers of glomerular damage （nephrin，podocalyxin，Wilms Tumor-1），biomarkers of tubular damage（neutrophil gelatinase-associated lipocalin，kidney injury molecule-1） and inflammatory factors（tumor necrosis factor receptor）. In the mean time，new approaches including urinary microRNAs （noncoding mRNAs） and urine proteomics provide new direction to identify potential novel biomarkers for detecting diabetic nephropathy.

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备注/Memo

备注/Memo:
通信作者：刘超，Email：liuchao@nfmcn.com
更新日期/Last Update: 2015-05-20