[1]邵滢,王秋月.MiRNA-150与糖尿病肾病[J].国际内分泌代谢杂志,2015,(03):173-175.[doi:10.3760/cma.j.issn.1673-4157.2015.03.008]
　Shao Ying,Wang Qiuyue..MiRNA-150 and diabetic nephropathy[J].International Journal of Endocrinology and Metabolism,2015,(03):173-175.[doi:10.3760/cma.j.issn.1673-4157.2015.03.008]
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MiRNA-150与糖尿病肾病()
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《国际内分泌代谢杂志》[ISSN:1673-4157/CN:12-1383/R]

卷:
期数:
2015年03
页码:
173-175
栏目:
肾脏疾病专栏
出版日期:
2015-05-20

文章信息/Info

Title:
MiRNA-150 and diabetic nephropathy
作者:
邵滢; 王秋月
110001　沈阳，中国医科大学附属第一医院内分泌科 　　
Author(s):
Shao Ying; Wang Qiuyue.
Department of Endocrinology，The First Affiliated Hospital，Chinese Medical University，Shenyang 110001，China Corresponding author：Wang Qiuyue，Email：wqycmu@163.com
关键词:
糖尿病肾病; MiRNA-150; 炎症; 肾脏纤维化
Keywords:
Diabetic nephropathy; MiRNA-150; Inflammation; Renal fibrosis
DOI:
10.3760/cma.j.issn.1673-4157.2015.03.008
摘要:
糖尿病肾病以肾间质纤维化和肾脏硬化为病理学特点，慢性低度炎性反应、氧化应激、新生血管形成、内皮功能紊乱等在糖尿病肾病的发生和发展中起重要作用。MiRNA-150参与多种炎性反应、调节炎性反应信号通路，在肾脏纤维化中表达升高，而且可以通过微泡促进新生血管形成，进而导致肾间质纤维化，肾脏硬化；其靶基因，如细胞因子信号转导抑制蛋白1（SOCS1）、基质细胞衍生因子-1（SDF-1）/趋化因子受体4（CXCR4）等在糖尿病肾病中起保护作用。因此，miRNA-150可能通过影响其下游信号分子的表达在糖尿病肾病的发生、发展中起重要作用。
Abstract:
The pathologic characteristics of diabetic nephropathy are renal interstitial fibrosis and renal sclerosis. Chronic low-grade inflammation，oxidative stress，angiogenesis and endothelial dysfunction play important roles in the occurrence and development of diabetic nephropathy. MiRNA-150，overexpressed in renal fibrosis，participates in a variety of inflammatory response and inflammatory signaling pathways. Through microvesicels，miRNA-150 can promote angiogenesis and then result in renal interstitial fibrosis and nephrosclerosis. Its target genes are protective in diabetic nephropathy，such as suppressor of cytokine signaling1（SOCS1），stromal cell-derived factor-1（SDF-1）/ CXC chemokine receptor4(CXCR4). Therefore，miRNA-150 may play a key role in the occurrence and development of diabetic nephropathy by modulating its downstream signaling molecules.

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备注/Memo

备注/Memo:
基金项目：辽宁省科学技术计划项目（2011225017）；辽宁省百千万人才工程资助项目（2011921037） 通信作者：王秋月，Email：wqycmu@163.com
更新日期/Last Update: 2015-05-20