[1]赵丽娟,徐宽枫,杨涛,等.SLC30A8和PTPRD基因多态性与南京地区中老年人群2型糖尿病的相关性研究[J].国际内分泌代谢杂志,2015,(03):145-148.[doi:10.3760/cma.j.issn.1673-4157.2015.03.001]
　Zhao Lijuan*,Xu Kuanfeng,Yang Tao,et al.Relationship between SLC30A8 and PTPRD gene polymorphisms and type 2 diabetes in middle aged and elderly people in Nanjing area[J].International Journal of Endocrinology and Metabolism,2015,(03):145-148.[doi:10.3760/cma.j.issn.1673-4157.2015.03.001]
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SLC30A8和PTPRD基因多态性与南京地区中老年人群2型糖尿病的相关性研究()
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《国际内分泌代谢杂志》[ISSN:1673-4157/CN:12-1383/R]

卷:
期数:
2015年03
页码:
145-148
栏目:
论著
出版日期:
2015-05-20

文章信息/Info

Title:
Relationship between SLC30A8 and PTPRD gene polymorphisms and type 2 diabetes in middle aged and elderly people in Nanjing area
作者:
赵丽娟; 徐宽枫; 杨涛; 戴皓; 马冰沁; 季荔; 陈阳; 施云; 郑帅; 胡晴芳;  张青青; 杨帆; 蒋琳
210029　南京医科大学第一附属医院内分泌科（赵丽娟，徐宽枫，杨涛，戴皓，马冰沁，季荔，陈阳，施云，郑帅，蒋琳）；215004　苏州大学附属第二医院内分泌科（胡晴芳）；225499　泰州市人民医院内分泌科（张青青）；214002　无锡市第二人民医院内分泌科（杨帆）
Author(s):
Zhao Lijuan*; Xu Kuanfeng; Yang Tao; Dai Hao; Ma Bingqin; Ji Li; Chen Yang; Shi Yun; Zheng Shuai; Hu Qingfang; Zhang Qingqing; Yang Fan; Jiang Lin.
*Department of Endocrinology，The First Affiliated Hospital of Nanjing Medical University，Nanjing 210029，China Corresponding author：Jiang Lin，Email：jlinna0000@163.com
关键词:
溶质载体家族30/锌转运体; 成员8; 蛋白酪氨酸磷酸酶受体D; 2型糖尿病; 单核苷酸多态性
Keywords:
Solute carrier family 30/zinc transporter; member 8; Protein tyrosine phosphatase receptor type D; Type 2 diabetes mellitus; Single nucleotide polymorphism
DOI:
10.3760/cma.j.issn.1673-4157.2015.03.001
摘要:
目的　探讨溶质载体家族30/锌转运体，成员8（SLC30A8）基因（rs13266634和rs3802177）和蛋白酪氨酸磷酸酶受体D （PTPRD）基因（rs17584499）单核苷酸多态性与南京地区中老年人群2型糖尿病的相关性。方法　对南京地区40岁以上人群行75 g口服葡萄糖耐量试验及问卷调查，选取2型糖尿病1 758例（糖尿病组），正常对照1 970名（对照组），提取外周血基因组DNA，对其SLC30A8和PTPRD基因3个目标位点的基因型进行检测，分析与2型糖尿病的关系。 结果　 SLC30A8基因位点rs13266634在糖尿病组的基因型频率（CC、CT和TT）分别为35.9%、48.2%和15.9%，对照组为33.3%、48.8%和17.9%，糖尿病组C等位基因频率高于对照组（χ2 =3.986，P =0.046），C等位基因携带者患2型糖尿病的风险是T等位基因的1.158倍[优势比（OR）=1.158， P =0.005]。位点rs3802177在糖尿病组的基因型频率（CC、CT和TT）分别为35.3%、48.2%和16.5%，对照组为32.1%、49.9%和18.0%，糖尿病组C等位基因频率高于对照组（χ2=4.085，P =0.043），C等位基因携带者患2型糖尿病的风险是T等位基因的1.162倍（OR =1.162，P =0.004）。PTPRD基因位点rs17584499在糖尿病组的基因型频率（CC、CT和TT）分别为81.9%、16.9%和1.2%，对照组为82.4%、16.5%和1.1%，两组基因频率分布无统计学差异（χ2=0.274，P =0.600）。 结论　SLC30A8基因位点rs13266634和rs3802177的C等位基因可能是2型糖尿病的风险基因，与南京地区中老年人群2型糖尿病相关，未发现PTPRD基因（rs17584499）与本地区2型糖尿病相关。
Abstract:
Objective　To explore the relationship between solute carrier family 30 /zinc transporter， member 8（SLC30A8）gene（rs13266634 and rs3802177） and protein tyrosine phosphatase receptor type D （PTPRD） gene （rs17584499） single nucleotide polymorphisms （SNPs） and type 2 diabetes in middle aged and elderly people in Nanjing area. Methods　Genomic DNA were extracted from peripheral blood of 1 758 type 2 diabetic patients （diabetes group） and 1 970 healthy controls （control group） who had received 75 g oral glucose tolerance test and questionnaire survey. All patients were all over 40 years old and came from Nanjing area.Genotypes of three target loci of gene SLC30A8 and PTPRD were detected. Relation between type 2 diabetes and genotype distribution were analyzed. Results　The frequencies of the three genotypes CC，CT and TT of SLC30A8 rs13266634 were 35.9%，48.2% and 15.9% in diabetes group and 33.3%，48.8% and 17.9% in control group， respectively. The C allele frequency in diabetes group was higher than that in control group （χ2 =3.986，P =0.046）. The risk of type 2 diabetes for C allele carriers was 1.158 times that of T allele [odd ratio（OR）=1.158，P =0.005]. The frequencies of three genotypes CC，CT and TT of rs3802177 were 35.3%，48.2% and 16.5% in diabetes group and 32.1%，49.9% and 18.0% in control group，respectively. The C allele frequency in diabetes group was higher than that in control group （χ2=4.085，P =0.043）. The risk of type 2 diabetes for C allele carriers was 1.162 times that of T allele（OR =1.162，P =0.004）. The distribution of CC， CT and TT of PTPRD rs17584499 in control group（81.9%，16.9% and 1.2%）and diabetes group（82.4%，16.5% and 1.1%） was not different（χ2=0.274，P =0.600）. Conclusions　The polymorphisms of rs13266634 and rs3802177 in SLC30A8 are associated with type 2 diabetes in middle aged and elderly people in Nanjing area. The C allele might be a risk allele of type 2 diabetes. There is no relationship between rs17584499 in PTPRD and type 2 diabetes in this area．

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备注/Memo

备注/Memo:
通信作者：蒋琳，Email：jlinna0000@163.com
更新日期/Last Update: 2015-05-20