[1]韩菲,杨立成,孙红喜,等.2型糖尿病合并不同分期慢性肾脏疾病患者的血压特点[J].国际内分泌代谢杂志,2015,(03):149-152.[doi:10.3760/cma.j.issn.1673-4157.2015.03.002]
 Han Fei*,Yang Licheng,Sun Hongxi,et al.Characteristics of blood pressure in type 2 diabetic patients with different degree of chronic kidney disease[J].International Journal of Endocrinology and Metabolism,2015,(03):149-152.[doi:10.3760/cma.j.issn.1673-4157.2015.03.002]
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2型糖尿病合并不同分期慢性肾脏疾病患者的血压特点()
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《国际内分泌代谢杂志》[ISSN:1673-4157/CN:12-1383/R]

卷:
期数:
2015年03
页码:
149-152
栏目:
论著
出版日期:
2015-05-20

文章信息/Info

Title:
Characteristics of blood pressure in type 2 diabetic patients with different degree of chronic kidney disease
作者:
韩菲杨立成孙红喜杨菊红常宝成
300070 天津医科大学代谢病医院糖尿病肾病科,卫生部激素与发育重点实验室(韩菲,孙红喜,杨菊红,常宝成);300070 天津医科大学(杨立成)   
Author(s):
Han Fei*Yang LichengSun HongxiYang JuhongChang Baocheng.
*Department of Nephrology,Key Lab of Hormones and Development,Ministry of Health,The Metabolic Diseases Hospital,Tianjin Medical University,Tianjin 300070,China Corresponding author:Chang Baocheng,Email:changbc1970@126.com
关键词:
糖尿病慢性肾脏疾病高血压昼夜节律
Keywords:
Diabetes mellitusChronic kidney diseaseHypertensionCircadian rhythm
DOI:
10.3760/cma.j.issn.1673-4157.2015.03.002
摘要:
目的 观察2型糖尿病合并不同分期慢性肾脏疾病(CKD)患者的血压特点。方法 将2型糖尿病合并CKD患者共409例,分为CKD1期组(127例)、CKD2期组(121例)、CKD3期组(81例)、CKD4期组(36例)、CKD5期组(44例),统计各组高血压发生率,比较各组血压水平、节律特点。结果 随CKD进展,2型糖尿病合并CKD患者高血压发生率逐渐增加(X2=28.363,P <0.05),单纯收缩期高血压比例逐渐升高(X2=15.324,P <0.05),脉压水平逐渐升高(F =16.229,P <0.05);血压节律方面,随CKD进展,夜间血压下降百分率逐渐降低(F =6.753,5.105,P 均<0.05),非杓型血压所占比例逐渐上升(X2=26.980,P <0.05)。结论 2型糖尿病患者合并CKD分期不同,血压异常改变特点不同,整体血压异常特点为收缩压升高为主,脉压增大,同时伴血压节律异常。
Abstract:
Objective To investigate the characteristics of blood pressure in type 2 diabetic patients with different degree of chronic kidney disease(CKD). Methods Four hundred and nine patients of type 2 diabetes with CKD were divided into 5 groups:stage 1 group(n =127),stage 2 group(n =121),stage 3 group (n=81),stage 4 group(n=36) and stage 5 group(n=44). The incidence of hypertension,variability of blood pressure and circadian rhythm were evaluated. Results In type 2 diabetic patients with CKD,the incidence of hypertension,proportion of isolated systolic hypertension and level of pulse pressure increased significantly with the progression of CKD(X2=28.363,15.324,F =16.229,all P < 0.05). And with the progression of CKD,the declining percentage of nocturnal blood pressure decreased(F =6.753,5.105,all P<0.05),while the percentage of non-dippers increased(X2=26.980,P <0.05). Conclusion The abnormality of blood pressure in type 2 diabetes is diverse at different stage of CKD,however increased systolic blood pressure and pulse pressure and abnormal circadian rhythm are common characters.

参考文献/References:

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备注/Memo

备注/Memo:
基金项目:国家自然科学基金资助项目(81173428,81373864) 通信作者: 常宝成,Email:changbc1970@126.com
更新日期/Last Update: 2015-05-20