[1]吕芳,李梅.甲状旁腺激素制剂治疗代谢性骨病[J].国际内分泌代谢杂志,2014,(03):180-183.[doi:10.3760/cma.j.issn.1673-4157.2014.03.010]
 Lyu Fang,Li Mei..Parathyroid hormone in the treatment of metabolic bone diseases[J].International Journal of Endocrinology and Metabolism,2014,(03):180-183.[doi:10.3760/cma.j.issn.1673-4157.2014.03.010]
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甲状旁腺激素制剂治疗代谢性骨病()
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《国际内分泌代谢杂志》[ISSN:1673-4157/CN:12-1383/R]

卷:
期数:
2014年03期
页码:
180-183
栏目:
综述(临床研究)
出版日期:
2014-06-30

文章信息/Info

Title:
Parathyroid hormone in the treatment of metabolic bone diseases
作者:
吕芳李梅
100730 北京,中国医学科学院,北京协和医学院,北京协和医院内分泌科,卫生部内分泌重点实验室   
Author(s):
Lyu FangLi Mei.
Department of Endocrinology,Key Laboratory of Endocrine,Ministry of Health,Peking Union Medical College Hospital,Chinese Academy of Medical Sciences & Peking Union Medical College,Beijing 100730,China Corresponding author:Li Mei,Email:limeizh@sina.com
关键词:
甲状旁腺激素制剂代谢性骨病治疗
Keywords:
Parathyroid hormoneMetabolic bone diseasesTreatment
DOI:
10.3760/cma.j.issn.1673-4157.2014.03.010
摘要:
甲状旁腺激素(PTH)是调节钙平衡及骨转换的重要内分泌激素。目前已有PTH氨基端1-34片段和PTH 1-84全段两种重组甲状旁腺激素,用于治疗严重原发性及糖皮质激素诱发性骨质疏松。最近研究发现,PTH制剂对甲状旁腺功能减退症、成骨不全症、低磷酸酶症等代谢性骨病也有良好疗效。
Abstract:
Parathyroid hormone(PTH) is an important hormone in maintaining calcium balance and modulating bone remodeling. Now there are two forms of recombinant PTH(PTH 1-34 and PTH 1-84) in the treatment of severe primary osteoporosis and glucocorticoid induced osteoporosis. Recently,PTH has been found to be effective in other metabolic bone diseases,such as hypoparathyroidism,osteogenesis imperfecta and hypophosphatasia.

参考文献/References:

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备注/Memo

备注/Memo:
基金项目:国家自然科学基金资助项目(81100623);国家临床重点专科课题(WBYZ 2011-873) 通信作者:李梅,Email: limeilzh@sina.com
更新日期/Last Update: 2014-05-20