[1]陈晔,李艳玲,王坚.天然免疫细胞在1型糖尿病中的作用[J].国际内分泌代谢杂志,2014,(03):184-187.[doi:10.3760/cma.j.issn.1673-4157.2014.03.011]
 Chen Ye,Li Yanling,Wang Jian..Role of innate immune cells in type 1 diabetes mellitus[J].International Journal of Endocrinology and Metabolism,2014,(03):184-187.[doi:10.3760/cma.j.issn.1673-4157.2014.03.011]
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天然免疫细胞在1型糖尿病中的作用()
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《国际内分泌代谢杂志》[ISSN:1673-4157/CN:12-1383/R]

卷:
期数:
2014年03期
页码:
184-187
栏目:
综述(基础研究)
出版日期:
2014-06-30

文章信息/Info

Title:
Role of innate immune cells in type 1 diabetes mellitus
作者:
陈晔李艳玲王坚
210002 南京军区南京总医院内分泌科   
Author(s):
Chen YeLi YanlingWang Jian.
Department of Endocrinology,Nanjing General Hospital of Nanjing Military Command,PLA,Nanjing 210002,China Corresponding author:Wang Jian,Email:wangjndcrn@aliyun.com
关键词:
1型糖尿病天然免疫细胞自身免疫
Keywords:
Type 1 diabetes mellitusInnate autoimmune cellsAutoimmune
DOI:
10.3760/cma.j.issn.1673-4157.2014.03.011
摘要:
1型糖尿病(T1DM)是一种复杂的自身免疫性疾病,主要是由T、B细胞破坏胰岛β细胞所致。虽然病因不明,但最终一系列天然免疫细胞及特异性免疫细胞相互作用,导致胰岛β细胞损伤和T1DM的发生。对动物模型和T1DM患者的研究发现,单核/巨噬细胞、自然杀伤细胞、自然杀伤T细胞、树突状细胞和淋巴细胞相互作用可影响T1DM的发生、发展。因此,研究天然免疫细胞在T1DM发生、发展中的作用,可能为防治T1DM提供新的方向。
Abstract:
Type 1 diabetes mellitus(T1DM) is a complex autoimmune disease resulting from the specific destruction of islet β cells by T cells and B cells. The pathogenesis of T1DM remains elusive. Ultimately,the interplay between natural immune cells and specific immune cells triggers the destruction of β cells and onset of T1DM. The interaction of macrophage,natural kill cell,natural killer T cells and dendritic cells induced by susceptible gene and environmental factors with antigen-specific lymphocytes has been implicated in the development of autoimmune diabetes in animal models and patients with T1DM.Studies of the role of natural immune cells in initiating T1DM may provide innovative clinical approaches for prevention or treatment of T1DM.

参考文献/References:

 [1] Roep BO,Kleijwegt FS,van Halteren AG,et al.Islet inflammation and CXCL10 in recent-onset type 1 diabetes[J].Clin Exp Immunol,2010,159(3):338-343.  
[2] Diana J,Simoni Y,Furio L,et al.Crosstalk between neutrophils,B-1a cells and plasmacytoid dendritic cells initiates autoim-mune diabetes[J].Nat Med,2013,19(1):65-73.  
[3] Ghazarian L,Diana J,Beaudoin L,et al.Protection against type 1 diabetes upon coxsackievirus B4 infection and iNKT-cell stimulation:role of suppressive macrophages[J].Diabetes,2013, 62(11):3785-3796.  
[4] Gur C,Porgador A,Elboim M,et al.The activating receptor NKp46 is essential for the development of type 1 diabetes[J].Nat Immunol,2010,11(2):121-128.  
[5] Feuerer M,Shen Y,Littman DR,et al.How punctual ablation of regulatory T cells unleashes an autoimmune lesion within the pancreatic islets[J].Immunity,2009,31(4):654-664.  
[6] Qin H,Lee IF,Panagiotopoulos C,et al.Natural killer cells from children with type 1 diabetes have defects in NKG2D-depen-dent function and signaling[J].Diabetes,2011,60(3):857-866.  
[7] Juno JA,Keynan Y,Fowke KR.Invariant NKT cells:regulation and function during viral infection[J].PLoS Pathog,2012,8(8):e1002838.  
[8] Blumenfeld HJ,Tohn R,Haeryfar SM,et al.Structure-guided design of an invariant natural killer T cell agonist for optimum protection from type 1 diabetes in non-obese diabetic mice[J].Clin Exp Immunol,2011,166(1):121-133.  
[9] Joyee AG,Uzonna J,Yang X.Invariant NKT cells preferentially modulate the function of CD8 alpha+ dendritic cell subset in inducing type 1 immunity against infection[J].J Immunol,2010, 184(4):2095-2106.
[10] Diana J,Griseri T,Lagaye S,et al.NKT cell-plasmacytoid dendritic cell cooperation via OX40 controls viral infection in a tissue-specific manner[J].Immunity,2009,30(2):289-299.
[11] Roman-Gonzalez A,Moreno ME,Alfaro JM,et al.Frequency and function of circulating invariant NKT cells in autoimmune dia-betes mellitus and thyroid diseases in Colombian patients[J]. Hum Immunol,2009,70(4):262-268.
[12] Ly D,Tohn R,Rubin B,et al.An alpha-galactosylceramide C20:2 N-acyl variant enhances anti-inflammatory and regulatory T cell-independent responses that prevent type 1 diabetes[J].Clin Exp Immunol,2010,160(2):185-198.
[13] Grieco FA,Vendrame F,Spagnuolo I,et al.Innate immunity and the pathogenesis of type 1 diabetes[J]. Semin Immunopathol,2011,33(1):57-66.
[14] Graham KL,Krishnamurthy B,Fynch S,et al.Intra-islet prolifer-ation of cytotoxic T lymphocytes contributes to insulitis progres-sion[J].Eur J Immunol,2012,42(7):1717-1722.
[15] Tonkin DR,Haskins K.Regulatory T cells enter the pancreas during suppression of type 1 diabetes and inhibit effector T cells and macrophages in a TGF-beta-dependent manner[J].Eur J Immunol,2009,39(5):1313-1322.
[16] Lee MS,Kwon HJ,Kim HS.Macrophages from nonobese diabetic mouse have a selective defect in IFN-gamma but not IFN-alpha/beta receptor pathway[J].J Clin Immunol,2012,32(4):753-761.
[17] Zhang J,Huang Z,Sun R,et al.IFN-gamma induced by IL-12 administration prevents diabetes by inhibiting pathogenic IL-17 production in NOD mice[J].J Autoimmun,2011,38(1):20-28.
[18] Parsa R,Andresen P,Gillett A,et al.Adoptive transfer of immunomodulatory M2 macrophages prevents type 1 diabetes in NOD mice[J].Diabetes,2012,61(11):2881-2892.
[19] Sia C,H?覿nninen A.Functional alterations of proinflammatory monocytes by T regulatory cells:implications for the prevention and reversal of type 1 diabetes[J].Rev Diabet Stud,2010,7(1):6-14.
[20] Allen JS,Pang K,Skowera A,et al.Plasmacytoid dendritic cells are proportionally expanded at diagnosis of type 1 diabetes and enhance islet autoantigen presentation to T-cells through immune complex capture[J].Diabetes,2009,58(1):138-145.
[21] Nieminen JK,Vakkila J,Salo HM,et al.Altered phenotype of peripheral blood dendritic cells in pediatric type 1 diabetes[J]. Diabetes Care,2012,35(11):2303-2310.
[22] Delmastro MM,Piganelli JD.Oxidative stress and redox modulation potential in type 1 diabetes[J].Clin Dev Immunol,2011, 2011:593863.
[23] Giannoukakis N,Phillips B,Finegold D,et al.PhaseⅠ (safety) study of autologous tolerogenic dendritic cells in type 1 diabetic patients[J].Diabetes Care,2011,34(9):2026-2032.

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备注/Memo

备注/Memo:
通信作者:王坚,Email:wangjndcrn@aliyun.com
更新日期/Last Update: 2014-05-20