[1]郭红伟,段宇.多氯联苯对甲状腺的干扰作用[J].国际内分泌代谢杂志,2014,(02):81-83.[doi:10.3760/cma.j.issn.1673-4157.2014.02.003]
 Guo Hongwei,Duan Yu..Effects of polychlorinated biphenyls on thyroid function[J].International Journal of Endocrinology and Metabolism,2014,(02):81-83.[doi:10.3760/cma.j.issn.1673-4157.2014.02.003]
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多氯联苯对甲状腺的干扰作用()
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《国际内分泌代谢杂志》[ISSN:1673-4157/CN:12-1383/R]

卷:
期数:
2014年02期
页码:
81-83
栏目:
甲状腺疾病专栏
出版日期:
2014-04-30

文章信息/Info

Title:
Effects of polychlorinated biphenyls on thyroid function
作者:
郭红伟段宇
210029 南京医科大学第一附属医院内分泌科   
Author(s):
Guo HongweiDuan Yu.
Department of Endocrinology,The First Affiliated Hospital of Nanjing Medical University,Nanjing 210029,China Corresponding author:Duan Yu,Email:duanyu@medmail.com.cn
关键词:
环境内分泌干扰物多氯联苯甲状腺
Keywords:
Environmental endocrine disruptorsPolychlorinated biphenylsThyroid
DOI:
10.3760/cma.j.issn.1673-4157.2014.02.003
摘要:
多氯联苯(PCBs)是环境内分泌干扰物中典型的持续性有机污染物(POPs),通过食物链在生物体内富集,对生物体内分泌系统、神经系统、生殖系统、免疫功能等产生严重损害。PCBs可诱导甲状腺结构破坏,影响甲状腺激素的合成、分泌和下丘脑-垂体-甲状腺功能轴。研究PCBs对甲状腺干扰作用的机制能够为寻找干预PCBs危害的有效手段提供新的思路。
Abstract:
Polychlorinated biphenyls (PCBs) are typical persistent organic pollutants in environmental endocrine disruptors that may bioaccumulate in organisms through the food chain and cause serious damage to endocrine system,nervous system,reproduction system,immune system and so on. PCBs can destroy thyroid gland,affect the synthesis and secretion of thyroid hormone,and cause abnormal function of hypothalamus-pituitary-thyroid axis. Studying the mechanism of PCBs-induced thyroid dysfunction may provide potential new insights for interventions to counteract the damages caused by PCBs.

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备注/Memo

备注/Memo:
基金项目:国家自然科学基金资助项目(81170726);江苏省医学重点人才(20111541);南京医科大学第一附属医院创新团队(20113012);江苏高校优势学科建设工程(PAPD) 通信作者:段宇,Email: duanyu@medmail.com.cn
更新日期/Last Update: 2014-03-20