[1]叶婷婷,董艳.表观遗传学在子代代谢性疾病发生中的作用[J].国际内分泌代谢杂志,2014,(01):60-62,66.[doi:10.3760/cma.j.issn.1673-4157.2014.01.017]
 Ye Tingting,Dong Yan.Role of epigenetics in the development of metabolic diseases in offsprings[J].International Journal of Endocrinology and Metabolism,2014,(01):60-62,66.[doi:10.3760/cma.j.issn.1673-4157.2014.01.017]
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表观遗传学在子代代谢性疾病发生中的作用()
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《国际内分泌代谢杂志》[ISSN:1673-4157/CN:12-1383/R]

卷:
期数:
2014年01期
页码:
60-62,66
栏目:
综述
出版日期:
2014-02-28

文章信息/Info

Title:
Role of epigenetics in the development of metabolic diseases in offsprings
作者:
叶婷婷董艳
200092 上海交通大学医学院附属新华医院内分泌科   
Author(s):
Ye TingtingDong Yan.
Department of Endocrinology,Xinhua Hospital,Shanghai Jiaotong University School of Medicine,Shanghai 200092,China Corresponding author:Dong Yan,Email:yandong00@hotmail.com
关键词:
母体营养表观遗传学代谢性疾病DNA甲基化组蛋白修饰非编码RNA调控
Keywords:
Maternal nutritionEpigeneticsMetabolic diseasesDNA MethylationHistone modifi-cationsNon-coding RNA regulation
DOI:
10.3760/cma.j.issn.1673-4157.2014.01.017
摘要:
相关动物实验及流行病学调查研究发现,子代发育早期特殊的营养状况如宫内发育迟缓和母体孕期低热量摄入、低蛋白饮食及高脂饮食,可通过表观遗传异常修饰改变子代代谢相关基因的表达水平,从而导致其日后代谢性疾病的发生。 表观遗传修饰主要包括DNA甲基化、组蛋白修饰和非编码RNA调控。这种发生在生命早期的变化属于健康和疾病的发育起源学说(Developmental Origins of Health and Disease Hypothesis,DOHaD)的范畴,其机制特别是表观遗传学研究方法的日益成熟,为指导孕期良好的饮食习惯,减少子代日后患代谢性疾病的风险提供参考。
Abstract:
Relevant animal experiments and epidemiological research findings support that in the early development special nutritional status, such as intrauterine growth restricted, maternal low-calorie, low-protein and high-fat diet during gestation,can change their expression of metabolism-related genes by modifying epigenetic abnormally that lead to the development of metabolic diseases in offsprings.Epigenetic modifications mainly include DNA methylation,histone modifications and non-coding RNA regulation. These modifications occurred in early life belong to the category of Developmental Origins of Health and Disease Hypothesis,and its mechanisms,especially its maturing methods on epigenetic research,can provide a reference to guide a healthy diet habit during pregnancy in order to reduce the risk of developing metabolic diseases in their offsprings later.

参考文献/References:

[1] Uauy R,Kain J,Corvalan C. How can the Developmental Origins of Health and Disease(DOHaD)hypothesis contribute to improving health in developing countries?[J] .Am J Clin Nutr,2011,94(6 Suppl):1759S-1764S.
[2] Clouaire T,Stancheva I.Methyl-CpG binding proteins:special-ized transcriptional repressors or structural components of chro-matin?[J].Cell Mol Life Sci,2008,65(10):1509-1522.
[3] Pham TX,Lee J.Dietary regulation of histone acetylases and deacetylases for the prevention of metabolic diseases[J].Nutrients,2012,4(12):1868-1886.
[4] Park JH,Stoffers DA,Nicholls RD,et al.Development of type 2 diabetes following intrauterine growth retardation in rats is associated with progressive epigenetic silencing of Pdx1[J].J Clin Invest,2008,118(16): 2316-2324.
[5] Simmons RA.Developmental origins of beta-cell failure in type 2 diabetes:the role of epigenetic mechanisms[J].Pediatr Res,2007,61(5 Pt 2):64R-67R.
[6] Pinney SE,Jaeckle Santos LJ,Han Y,et al.Exendin-4 increases histone acetylase activity and reverses epigenetic modifications that silence Pdx1 in the intrauterine growth retarded rat[J].Diabetologia,2011,54(10):2606-2614 .
[7] Heijmans BT,Tobi EW,Stein AD,et al.Persistent epigenetic differences associated with prenatal exposure to famine in humans[J].Proc Natl Acad Sci U S A,2008,105(44):17046-17049.
[8] Raychaudhuri N,Raychaudhuri S,Thamotharan M,et al.Histone code modifications repress glucose transporter 4 expression in the intrauterine growth-restricted offspring[J].J Biol Chem,2008,283(20): 13611-13626.
[9] Zheng S,Rollet M,Pan YX.Protein restriction during gestation alters histone modifications at the glucose transporter 4 (GLUT4)promoter region and induces GLUT4 expression in skeletal muscle of female rat offspring[J].J Nutr Biochem,2012,23(9):1064-1071.
[10] Plagemann A,Harder T,Schellong K,et al.Early postnatal life as a critical time window for determination of long-term metabolic health[J]. Best Pract Res Clin Endocrinol Metab,2012,26(5):641-653.
[11] Plagemann A,Roepke K,Harder T,et al.Epigenetic malpro-gramming of the insulin receptor promoter due to developmental overfeeding[J].J Perinat Med,2010,38(4):393-400.
[12] Tosh DN,Fu Q,Callaway CW,et al.Epigenetics of programmed obesity:alteration in IUGR rat hepatic IGF1 mRNA expression and histone structure in rapid vs.delayed postnatal catch-up growth[J].Am J Physiol Gastrointest Liver Physiol,2010,299(5):G1023-G1029.
[13] Sandovici I,Smith NH,Nitert MD,et al.Maternal diet and aging alter the epigenetic control of a promoter-enhancer interaction at the Hnf4α gene in rat pancreatic islets[J].Proc Natl Acad Sci U S A,2011,108(13):5449-5454.
[14] Vucetic Z,Kimmel J,Totoki K,et al.Maternal high-fat diet alters methylation and gene expression of dopamine and opioid-related genes[J].Endocrinology,2010,151(10):4756-4764.
[15] Dudley KJ,Sloboda DM,Connor KL,et al.Offspring of mothers fed a high fat diet display hepatic cell cycle inhibition and associated changes in gene expression and DNA methylation[J].PLoS One,2011,6(7):e21662.
[16] Strakovsky RS,Zhang X,Zhou D,et al.Gestational high fat diet programs hepatic phosphoenolpyruvate carboxykinase gene expression and histone modification in neonatal offspring rats[J].J Physiol,2011,589(Pt 11):2707-2717.
[17] Zhang J,Zhang F,Didelot X,et al.Maternal high fat diet during pregnancy and lactation alters hepatic expression of insulin like growth factor-2 and key microRNAs in the adult offspring[J].BMC Genomics, 2009,10:478.

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备注/Memo

备注/Memo:
基金项目:上海交通大学科技基金项目(11XJ21037) 通信作者:董艳,Email:yandong00@hotmail.com
更新日期/Last Update: 2014-01-20