[1]晁爱军.地舒单抗和罗莫佐单抗治疗骨质疏松症的进展及展望[J].国际内分泌代谢杂志,2023,43(04):283-386.[doi:10.3760/cma.j.cn121383-20230708-07013]
 Chao Aijun.Progress and prospects of denosumab and romosozumab in osteoporosis treatment[J].International Journal of Endocrinology and Metabolism,2023,43(04):283-386.[doi:10.3760/cma.j.cn121383-20230708-07013]
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地舒单抗和罗莫佐单抗治疗骨质疏松症的进展及展望()
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《国际内分泌代谢杂志》[ISSN:1673-4157/CN:12-1383/R]

卷:
43
期数:
2023年04期
页码:
283-386
栏目:
述评
出版日期:
2023-07-20

文章信息/Info

Title:
Progress and prospects of denosumab and romosozumab in osteoporosis treatment
作者:
晁爱军
天津市天津医院骨内科,天津 300211
Author(s):
Chao Aijun
Department of Osteo-internal, Tianjin Hospital, Tianjin 300211, China
关键词:
骨质疏松症 地舒单抗 罗莫佐单抗 生物制剂
Keywords:
Osteoporosis Denosumab Romosozumab Biologics
DOI:
10.3760/cma.j.cn121383-20230708-07013
摘要:
地舒单抗和罗莫佐单抗是目前治疗骨质疏松症仅有的两个生物制剂,分属于抑制骨吸收及双向调节机制药物。目前的证据显示地舒单抗在长期治疗中是安全和有效的。罗莫佐单抗是强效的抗骨质疏松治疗药品,能够快速提高骨密度,但必须序贯抗骨吸收药物,目前应当关注其心血管风险。以往的骨质疏松治疗史可能影响罗莫佐单抗的疗效。罗莫佐单抗对于骨密度的改善作用,使进一步降低骨质疏松性骨折风险成为可能。
Abstract:
Denosumab and romosozumab are the only two biologics for the treatment of osteoporosis, belonging to bone resorption inhibitors and bidirectional regulatory drugs, respectively. Current evidence shows that denosumab is safe and effective in long-term treatment. Romosozumab is a potent anti-osteoporosis treatment that can rapidly improve bone density, but must be sequentially followed by anti-bone resorption drugs, and cardiovascular risks should be alerted. A history of previous osteoporosis treatment may affect the efficacy of romosozumab. The effect of romosozumab on bone mineral density makes it possible to further reduce the risk of osteoporotic fractures.

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备注/Memo

备注/Memo:
通信作者:晁爱军,Email:ajoinmail@126.com
更新日期/Last Update: 2023-08-15