[1]刘美娟 朱惠娟 龚凤英.间歇性禁食改善代谢性疾病的作用及其机制[J].国际内分泌代谢杂志,2018,38(06):415-418.[doi:10.3760/cma.j.issn.1673-4157.2018.06.014]
 Liu Meijuan,Zhu Huijuan,Gong Fengying.Effects of intermittent fasting in improving metabolic diseases and its mechanism[J].International Journal of Endocrinology and Metabolism,2018,38(06):415-418.[doi:10.3760/cma.j.issn.1673-4157.2018.06.014]
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间歇性禁食改善代谢性疾病的作用及其机制()
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《国际内分泌代谢杂志》[ISSN:1673-4157/CN:12-1383/R]

卷:
38
期数:
2018年06期
页码:
415-418
栏目:
基础研究
出版日期:
2018-11-20

文章信息/Info

Title:
Effects of intermittent fasting in improving metabolic diseases and its mechanism
作者:
刘美娟 朱惠娟 龚凤英
作者单位:100730 北京,中国医学科学院,北京协和医学院,北京协和医院内分泌科,国家卫生健康委员会内分泌重点实验室,协和转化医学中心
Author(s):
Liu Meijuan Zhu Huijuan Gong Fengying
Key Laboratory of Endocrinology of National Health and Family Planning Commission, Department of Endocrinology, The Translational Medicine Center of PUMCH, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical
关键词:
间歇性禁食 肥胖 2型糖尿病
Keywords:
Intermittent fasting Obesity Type 2 diabetes meuitus
DOI:
10.3760/cma.j.issn.1673-4157.2018.06.014
摘要:
间歇性禁食也称轻断食,是指通过禁食与自由饮食周期性交替进行来达到防治疾病的一种饮食疗法。近几年的研究发现,间歇性禁食具有降低体重、改善胰岛素敏感性和血脂及降低血压等多种作用,从而有效地预防和治疗肥胖、2型糖尿病等代谢性疾病。其作用机制包括调节机体生物节律、肠道菌群和改变生活方式等。间歇性禁食的上述作用使其有望成为未来治疗肥胖等相关代谢性疾病的一种新的饮食疗法。
Abstract:
Intermittent fasting, also known as the fast diet, refers to a dietary therapy that prevents and treats disease by periodically switching between fasting and free diet. In recent years, studies have found that intermittent fasting has many beneficial effects such as reducing body weight, improving insulin sensitivity and blood lipids, and lowering blood pressure. Thereby, intermittent fasting can effectively prevent and treat several metabolic diseases, including obesity, type 2 diabetes, etc. The mechanisms include regulating circadian biology, the gut microbiome and modifying lifestyle behaviors. The above-mentioned beneficial effects of intermittent fasting make it possible to become a new dietary therapy for the treatment of obesity and its related metabolic disorders in the future.

参考文献/References:


[1] Anton SD,Moehl K,Donahoo WT,et al.Flipping the metabolic switch: understanding and applying the health benefits of fasting[J].Obesity(Silver Spring),2018,26(2):254-268.DOI:10.1002/oby.22065.
[2] Patterson RE,Sears DD.Metabolic effects of intermittent fasting[J].Annu Rev Nutr,2017,37:371-393.DOI:10.1146/annurev-nutr-071816-064634.
[3] Mattson MP,Longo VD,Harvie M.Impact of intermittent fasting on health and disease processes[J].Ageing Res Rev,2017,39:46-58.DOI:10.1016/j.arr.2016.10.005.
[4] Patterson RE,Laughlin GA,LaCroix AZ,et al.Intermittent fasting and human metabolic health[J].J Acad Nutr Diet,2015,115(8):1203-1212.DOI:10.1016/j.jand.2015.02.018.
[5] Li G,Xie C,Lu S,et al.Intermittent fasting promotes white adipose browning and decreases obesity by shaping the gut microbiota[J].Cell Metab,2017,26(4):672-685.e4.DOI:10.1016/j.cmet.2017.08.019.
[6] Baumeier C,Kaiser D,Heeren J,et al.Caloric restriction and intermittent fasting alter hepatic lipid droplet proteome and diacylglycerol species and prevent diabetes in NZO mice[J].Biochim Biophys Acta,2015,1851(5):566-576.DOI:10.1016/j.bbalip.2015.01.013.
[7] Varady KA,Roohk DJ,Loe YC,et al.Effects of modified alternate-day fasting regimens on adipocyte size, triglyceride metabolism, and plasma adiponectin levels in mice[J].J Lipid Res,2007,48(10):2212-2219.DOI:10.1194/jlr.M700223-JLR200.
[8] Heilbronn LK,Smith SR,Martin CK,et al.Alternate-day fasting in nonobese subjects: effects on body weight, body composition, and energy metabolism[J].Am J Clin Nutr,2005,81(1):69-73.DOI:10.1093/ajcn/81.1.69.
[9] Varady KA.Intermittent versus daily calorie restriction: which diet regimen is more effective for weight loss [J].Obes Rev,2011,12(7):e593-e601.DOI:10.1111/j.1467-789X.2011.00873.x.
[10] Harris L,Hamilton S,Azevedo LB,et al.Intermittent fasting interventions for treatment of overweight and obesity in adults: a systematic review and meta-analysis[J].JBI Database System Rev Implement Rep,2018,16(2):507-547.DOI:10.11124/JBISRIR-2016-003248.
[11] Hatori M,Vollmers C,Zarrinpar A,et al.Time-restricted feeding without reducing caloric intake prevents metabolic diseases in mice fed a high-fat diet[J].Cell Metab,2012,15(6):848-860.DOI:10.1016/j.cmet.2012.04.019.
[12] Anson RM,Guo Z,de Cabo R,et al.Intermittent fasting dissociates beneficial effects of dietary restriction on glucose metabolism and neuronal resistance to injury from calorie intake[J].Proc Natl Acad Sci U S A,2003,100(10):6216-6220. DOI:10.1073/pnas.1035720100.
[13] Tikoo K,Tripathi DN,Kabra DG,et al.Intermittent fasting prevents the progression of type I diabetic nephropathy in rats and changes the expression of Sir2 and p53[J].FEBS Lett,2007,581(5):1071-1078.DOI:10.1016/j.febslet.2007.02.006.
[14] Seimon RV,Roekenes JA,Zibellini J,et al.Do intermittent diets provide physiological benefits over continuous diets for weight loss:a systematic review of clinical trials[J].Mol Cell Endocrinol,2015,418 Pt 2:153-172.DOI:10.1016/j.mce.2015.09.014.
[15] Halberg N,Henriksen M,Söderhamn N,et al.Effect of intermittent fasting and refeeding on insulin action in healthy men[J].J Appl Physiol(1985),2005,99(6):2128-2136.DOI:10.1152/japplphysiol.00683.2005.
[16] Challet E.Circadian clocks,food intake, and metabolism[J].Prog Mol Biol Transl Sci,2013,119:105-135.DOI:10.1016/B978-0-12-396971-2.00005-1.
[17] Scheer FA,Hilton MF,Mantzoros CS,et al.Adverse metabolic and cardiovascular consequences of circadian misalignment[J].Proc Natl Acad Sci U S A,2009,106(11):4453-4458.DOI:10.1073/pnas.0808180106.
[18] Eckel-Mahan KL,Patel VR,de Mateo S,et al.Reprogramming of the circadian clock by nutritional challenge[J].Cell,2013,155(7):1464-1478.DOI:10.1016/j.cell.2013.11.034.
[19] 容祖华,梁少聪,路浚齐,等. 间歇性断食对老年前期肥胖大鼠肠道菌群及代谢的影响[J].南方医科大学学报,2016, 37(4):423-430.DOI:10.3969/j.issn.1673-4254.2017.04.01.
[20] Harvie M,Wright C,Pegington M,et al.The effect of intermittent energy and carbohydrate restriction v. daily energy restriction on weight loss and metabolic disease risk markers in overweight women[J].Br J Nutr,2013,110(8):1534-1547.DOI:10.1017/S0007114513000792.
[21] Harvie MN, Pegington M, Mattson MP,et al. The effects of intermittent or continuous energy restriction on weight loss and metabolic disease risk markers: a randomized trial in young overweight women[J].Int J Obes(Lond),2011,35(5):714-727.DOI:10.1038/ijo.2010.171.
[22] Rangan A,Zheng M,Olsen NJ,et al.Shorter sleep duration is associated with higher energy intake and an increase in BMI z-score in young children predisposed to overweight[J].Int J Obes(Lond),2018,42(1):59-64.DOI:10.1038/ijo.2017.216.
[23] Catenacci VA,Pan Z,Ostendorf D,et al.A randomized pilot study comparing zero-calorie alternate-day fasting to daily caloric restriction in adults with obesity[J].Obesity(Silver Spring),2016,24(9):1874-1883.DOI:10.1002/oby.21581.
[24] Trepanowski JF,Kroeger CM,Barnosky A,et al.Effect of alternate-day fasting on weight loss, weight maintenance, and cardioprotection among metabolically healthy obese adults: a randomized clinical trial[J].JAMA Intern Med,2017,177(7):930-938.DOI:10.1001/jamainternmed.2017.0936.

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备注/Memo

备注/Memo:
基金项目:国家自然科学基金(30540036,30771026,81370898); 北京市自然科学基金(7082079,7182130); 人社部留学人员科技活动项目择优资助经费(启动类); 国家临床重点专科建设项目单位(WBYZ2011-873)
Fund program:National Natural Science Foundation of China(30540036, 3630771026, 81370898); Natural Science Foundation of Bei
更新日期/Last Update: 2018-12-30