[1]温馨 路晓洁 邬瑞金 程晓芸 尤慧 杨篷 钱春花 盛春君 崔冉 李虹 曲伸 卜乐.脂质运载蛋白2在肥胖及其相关疾病中的作用[J].国际内分泌代谢杂志,2018,38(06):405-408.[doi:10.3760/cma.j.issn.1673-4157.2018.06.011]
 Wen Xin,Lu Xiaojie,Wu Ruijin,et al.Effects of lipocalin 2 in obesity and its related diseases[J].International Journal of Endocrinology and Metabolism,2018,38(06):405-408.[doi:10.3760/cma.j.issn.1673-4157.2018.06.011]
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脂质运载蛋白2在肥胖及其相关疾病中的作用()
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《国际内分泌代谢杂志》[ISSN:1673-4157/CN:12-1383/R]

卷:
38
期数:
2018年06期
页码:
405-408
栏目:
综述
出版日期:
2018-11-20

文章信息/Info

Title:
Effects of lipocalin 2 in obesity and its related diseases
作者:
温馨 路晓洁 邬瑞金 程晓芸 尤慧 杨篷 钱春花 盛春君 崔冉 李虹 曲伸 卜乐
作者单位:200072 上海,同济大学附属第十人民医院内分泌与代谢病科
Author(s):
Wen Xin Lu Xiaojie Wu Ruijin Cheng Xiaoyun You Hui Yang Peng Qian Chunhua Sheng Chunjun Cui Ran Li Hong Qu Shen Bu Le
Department of Endocrinology and Metabolism, Tenth People's Hospital, Tongji University School of Medicine, Shanghai 200072, China
关键词:
脂质运载蛋白2 糖尿病 肥胖
Keywords:
Lipocalin 2 Diabetes mellitus Obesity
DOI:
10.3760/cma.j.issn.1673-4157.2018.06.011
摘要:
脂质运载蛋白2(LCN2)也称中性粒细胞酶相关脂质运载蛋白,由成骨细胞、脂肪细胞和多种上皮细胞释放,可通过下丘脑影响摄食,调节炎性反应通路和能量代谢,造成脂肪组织功能紊乱,并可影响胰岛素受体信号转导通路,促进全身系统性炎性微环境的形成及胰岛素抵抗的发生,从而促进肥胖和相关疾病的发生、发展。基于其表达广泛性和易检测性,LCN2已经成为一种重要的生物标志物。研究LCN2在肥胖和相关疾病中的作用及调控机制,对于预防和治疗相关疾病有着重要意义。
Abstract:
Lipocalin 2(LCN2), also known as neutrophil gelatinase-associated lipocalin, is released by osteoblasts, adipocytes and various epithelial cells. LCN2 affects food intake through the hypothalamus, leads to dysfunction of adipose tissue by regulating inflammatory pathway and energy metabolism, as well as, promotes the formation of systemic inflammatory microenvironment and the occurrence of insulin resistance by regulating insulin receptor signal transduction pathway. LCN2 has been shown to be associated with the development of obesity and its related diseases. It has emerged as an important biomarker based on its extensive expression and easy detection. Study the role and regulation of LCN2 in obesity and obesity related diseases is of great significance for the prevention and treatment of related diseases.

参考文献/References:


[1] Abella V,Scotece M,Conde J,et al. The potential of lipocalin-2/NGAL as biomarker for inflammatory and metabolic diseases[J].Biomarkers,2015,20(8):565-571.DOI:10.3109/1354750X.2015.1123354.
[2] Xiao X,Yeoh BS,Vijay-Kumar M. Lipocalin 2:an emerging player in iron homeostasis and inflammation[J].Annu Rev Nutr,2017,37:103-130. DOI:10.1146/annurev-nutr-071816-064559.
[3] Wang Y,Lam KS,Kraegen EW,et al.Lipocalin-2 is an inflammatory marker closely associated with obesity, insulin resistance, and hyperglycemia in humans[J].Clin Chem,2007,53(1):34-41.DOI:10.1373/clinchem.2006.075614
[4] Catalán V,Gómez-Ambrosi J,Rodríguez A,et al.Increased adipose tissue expression of lipocalin-2 in obesity is related to inflammation and matrix metalloproteinase-2 and metalloproteinase-9 activities in humans[J].J Mol Med(Berl),2009,87(8):803-813.DOI:10.1007/s00109-009-0486-8.
[5] Luo Y,Ma X,Pan X,et al.Serum lipocalin-2 levels are positively associated with not only total body fat but also visceral fat area in Chinese men[J]. Medicine(Baltimore), 2016,95(30):e4039. DOI:10.1097/MD.0000000000004039.
[6] Zhao P,Elks CM,Stephens JM.et al.The induction of lipocalin-2 protein expression in vivo and in vitro[J].J Biol Chem,2014,289(9):5960-5969.DOI:10.1074/jbc.M113.532234.
[7] Glaros T,Fu Y,Xing J,et al.Molecular mechanism underlying persistent induction of LCN2 by lipopolysaccharide in kidney fibroblasts[J].PLoS One,2012,7(4):e34633.DOI:10.1371/journal.pone.0034633.
[8] Zhang J,Wu Y,Zhang Y,et al.The role of lipocalin 2 in the regulation of inflammation in adipocytes and macrophages[J].Mol Endocrinol,2008,22(6):1416-1426. DOI:10.1210/me.2007-0420.
[9] Zhang Y,Guo H,Deis JA,et al.Lipocalin 2 regulates brown fat activation via a nonadrenergic activation mechanism[J].J Biol Chem,2014,289(32):22063-22077.DOI:10.1074/jbc.M114.559104.
[10] Mosialou I,Shikhel S,Liu JM,et al.MC4R-dependent suppression of appetite by bone-derived lipocalin 2[J].Nature,2017,543(7645):385-390.DOI:10.1038/nature21697.
[11] Xiang Y,Zhou P,Li X,et al.Heterogeneity of altered cytokine levels across the clinical spectrum of diabetes in China[J].Diabetes Care,2011,34(7):1639-1641.DOI:10.2337/dc11-0039.
[12] Moreno-Navarrete JM,Manco M,Ibánez J,et al.Metabolic endotoxemia and saturated fat contribute to circulating NGAL concentrations in subjects with insulin resistance[J].Int J Obes(Lond),2010,34(2):240-249.DOI:10.1038/ijo.2009.242.
[13] De la Chesnaye E, Manuel-Apolinar L, Zarate A,et al. Lipocalin-2 plasmatic levels are reduced in patients with long-term type 2 diabetes mellitus[J].Int J Clin Exp Med,2015,8(2):2853-2859.
[14] Guo H,Jin D,Zhang Y,et al.Lipocalin-2 deficiency impairs thermogenesis and potentiates diet-induced insulin resistance in mice[J].Diabetes,2010,59(6):1376-1385. DOI:10.2337/db09-1735.
[15] Jun LS,Siddall CP,Rosen ED.A minor role for lipocalin 2 in high-fat diet-induced glucose intolerance[J].Am J Physiol Endocrinol Metab,2011,301(5):E825-E835. DOI:10.1152/ajpendo.00147.2011.
[16] Zhang Y,Foncea R,Deis JA,et al.Lipocalin 2 expression and secretion is highly regulated by metabolic stress, cytokines, and nutrients in adipocytes[J]. PLoS One,2014,9(5):e96997.DOI:10.1371/journal.pone.0096997.
[17] Tan BK,Adya R,Shan X,et al.Ex vivo and in vivo regulation of lipocalin-2, a novel adipokine, by insulin[J]. Diabetes Care,2009,32(1):129-131. DOI:10.2337/dc08-1236.
[18] Law IK,Xu A,Lam KS,et al.Lipocalin-2 deficiency attenuates insulin resistance associated with aging and obesity[J].Diabetes,2010,59(4):872-882.DOI:10.2337/db09-1541.
[19] Wang Y,Lam KS,Kraegen EW,et al.Lipocalin-2 is an inflammatory marker closely associated with obesity, insulin resistance, and hyperglycemia in humans[J].Clin Chem,2007,53(1):34-41. DOI:10.1373/clinchem.2006.075614.
[20] Ye D,Yang K,Zang S,et al.Lipocalin-2 mediates non-alcoholic steatohepatitis by promoting neutrophil-macrophage crosstalk via the induction of CXCR2[J].J Hepatol,2016,65(5):988-997.DOI:10.1016/j.jhep.2016.05.041.
[21] Cai Y,Jogasuria A,Yin H,et al.The detrimental role played by lipocalin-2 in alcoholic fatty liver in mice[J].Am J Pathol,2016,186(9):2417-2428.DOI:10.1016/j.ajpath.2016.05.006.

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备注/Memo

备注/Memo:
基金项目:上海市青年科技英才扬帆计划项目(14YF1412400)
Fund program:Shanghai Sailing Science Fund for Youth Scholars(14YF1412400)
作者单位:200072 上海,同济大学附属第十人民医院内分泌与代谢病科
通信作者:卜乐, Email: geyingjun@hotmail.com
更新日期/Last Update: 2018-12-30