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¡¡Wang Bingyu,Sun Jianping,Duan Wei.Mechanism of Th1, Th2, Th17 related cytokines in thyroid-associated ophthalmopathy[J].International Journal of Endocrinology and Metabolism,2018,38(06):394-396408.[doi:10.3760/cma.j.issn.1673-4157.2018.06.008]
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394-396408
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2018-11-20

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Title:
Mechanism of Th1, Th2, Th17 related cytokines in thyroid-associated ophthalmopathy
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Author(s):
Wang Bingyu Sun Jianping Duan Wei
Department of Endocrinology, The Affiliated Zhongshan Hospital of Dalian University, Dalian 116001, China
¹Ø¼ü´Ê:
Th1 Th2 Th17 ϸ°ûÒò×Ó ¼××´ÏÙÏà¹ØÑÛ²¡
Keywords:
Th1 Th2 Th17 Cytokine Thyroid-associated ophthalmopathy
DOI:
10.3760/cma.j.issn.1673-4157.2018.06.008
ÕªÒª:
¼××´ÏÙÏà¹ØÑÛ²¡(TAO)ÊÇ×ÔÉíÃâÒßÎÉÂÒ¡¢ÒÅ´«¡¢»·¾³µÈ¶àÒòËع²Í¬Ó°ÏìµÄÆ÷¹ÙÌØÒìÐÔ×ÔÉíÃâÒßÐÔ¼²²¡¡£¸¨ÖúÐÔTϸ°û(Th)1¡¢Th2¡¢Th17Ïà¹Øϸ°ûÒò×ÓÔÚTAOÖз¢»ÓÖØÒªµÄ×÷Óá£Ð½üÑо¿±íÃ÷, Tim3/Gal9ͨ·¡¢miRNA-146aÒÔ¼°¹ýÑõ»¯ÎïøÌåÔöÖ³Îï»î»¯ÊÜÌå-¦Ã¶¼¿ÉÔÚTh1/Th2·Ö»¯¡¢ÔöÖ³·½ÃæÆð¹Ø¼ü×÷Óá£Th17·ÖÃڵİ×ϸ°û½éËØ-17, ÓÐÖ²¡ÐԺͷÇÖ²¡ÐÔÁ½ÖÖ, µ÷¿ØTh17¿ÉÒÔ¸ÄÉÆTAOµÄ½øÕ¹¡£
Abstract:
Thyroid-associated ophthalmopathy(TAO)is an organ-specific autoimmune disease which involves a variety of pathogenic factors such as autoimmune disorders, heredity and environment. T-helper cell(Th)1, Th2 and Th17 related cytokines play vital roles in TAO. The lately research shows that Tim3/Gal9 pathway, miRNA-146a and peroxisome proliferator-activated receptor-¦Ã play key roles in Th1/Th2 differentiation and proliferation. Th17 can secrete interleukin-17, which is both pathogenic and non-pathogenic. The regulation of Th17 differentiation may improve the progression of TAO.

²Î¿¼ÎÄÏ×/References:


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±¸×¢/Memo:
»ù½ðÏîÄ¿:2018Äê´óÁ¬ÊÐҽѧ¿ÆѧÑо¿¼Æ»®ÏîÄ¿(1811104)
Fund program:Medical Science Research Project of Dalian in 2018(1811104)
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ͨÐÅ×÷Õß:¶ÎÞ±,Email:duanwei34@hotmail.com
¸üÐÂÈÕÆÚ/Last Update: 2018-12-30