[1]杨可来尔 匡洪宇.NLRP3炎性小体与糖尿病肾病[J].国际内分泌代谢杂志,2018,38(04):271-274.[doi:10.3760/cma.j.issn.1673-4157.2018.04.013]
 Yang Kelai'er,Kuang Hongyu..NLRP3 inflammasome and diabetic nephropathy[J].International Journal of Endocrinology and Metabolism,2018,38(04):271-274.[doi:10.3760/cma.j.issn.1673-4157.2018.04.013]
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NLRP3炎性小体与糖尿病肾病()
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《国际内分泌代谢杂志》[ISSN:1673-4157/CN:12-1383/R]

卷:
38
期数:
2018年04期
页码:
271-274
栏目:
基础研究
出版日期:
2018-07-20

文章信息/Info

Title:
NLRP3 inflammasome and diabetic nephropathy
作者:
杨可来尔 匡洪宇
150000 哈尔滨医科大学附属第一医院内分泌科
Author(s):
Yang Kelai'er Kuang Hongyu.
.Department of Endocrinology, The First Affiliated Hospital of Harbin Medical University, Harbin 150000, China
关键词:
NOD样受体蛋白3炎性小体 糖尿病肾病 炎症
Keywords:
NOD-like receptor protein 3 inflammasome Diabetic nephropathy Inflammation
DOI:
10.3760/cma.j.issn.1673-4157.2018.04.013
摘要:
NOD 样受体蛋白3(NLRP3)炎性小体是由NLRP3、凋亡相关斑点样蛋白(ASC)和caspase-1组成的蛋白复合体,通过识别病原微生物等危险信号,促进白细胞介素(IL)-1β和IL-18的分泌和释放,进而引起炎性反应。糖尿病肾病作为一种炎性相关疾病,可被多种炎性介质介导,而NLRP3炎性小体与糖尿病肾病的发生关系密切,并受多种信号通路的调节,其中丝裂原活化蛋白激酶信号通路是重要的关键环节。此外,活性氧簇也参与了NLRP3炎性小体介导的糖尿病肾病的发展。
Abstract:
NOD-like receptor protein 3(NLRP3)inflammasome is a kind of protein complex that composes of NLRP3, apoptosis-associated speck-like protein containing a CARD(ASC)and caspase-1, which causes inflammatory reaction through the identification of danger signals such as pathogenic microorganisms, and then promotes the secretion and release of interleukin(IL)-1β and IL-18. Diabetic nephropathy is regarded as an inflammation-related disease which can be mediated by a variety of inflammatory mediators, while NLRP3 inflammasome is closely associated with diabetic nephropathy and regulated by multiple signaling pathways. Among them, mitogen-activated protein kinase pathway plays an important role. In addition, reactive oxygen species are also involved in the development of diabetic nephropathy mediated by NLRP3 inflammasome.

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备注/Memo

备注/Memo:
基金项目:黑龙江省自然科学基金(D201253)
通信作者:匡洪宇,Email:ydyykuanghongyu@126.com
更新日期/Last Update: 2018-04-30